Initial activation of proMMP13 by MMP14 (MT1-MMP)

Stable Identifier
R-HSA-1604741
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
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Initial activation of proMMP13 by MMP14 (MT1-MMP)
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MMP14 (MT1-MMP) initially cleaves MMP13 at Gly54-Ile55 (Knauper et al. 1996a, 1996b) followed by autoprocessing at Glu103-Tyr104.
Literature References
PubMed ID Title Journal Year
8663255 Cellular mechanisms for human procollagenase-3 (MMP-13) activation. Evidence that MT1-MMP (MMP-14) and gelatinase a (MMP-2) are able to generate active enzyme

Knäuper, V, Will, H, López-Otin, C, Smith, B, Atkinson, SJ, Stanton, H, Hembry, RM, Murphy, G

J Biol Chem 1996
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Input
Output
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as an event of
Catalyst Activity

serine-type endopeptidase activity of MMP14 (16) [plasma membrane]

Physical Entity
MMP14 (16) [plasma membrane] (Homo sapiens)
Activity
serine-type endopeptidase activity (GO:0004252)
Orthologous Events
Initial activation of proMMP13 by MMP14 (MT1-MMP) (Bos taurus)
Initial activation of proMMP13 by MMP14 (MT1-MMP) (Caenorhabditis elegans)
Initial activation of proMMP13 by MMP14 (MT1-MMP) (Canis familiaris)
Initial activation of proMMP13 by MMP14 (MT1-MMP) (Drosophila melanogaster)
Initial activation of proMMP13 by MMP14 (MT1-MMP) (Mus musculus)
Initial activation of proMMP13 by MMP14 (MT1-MMP) (Rattus norvegicus)
Initial activation of proMMP13 by MMP14 (MT1-MMP) (Sus scrofa)
Initial activation of proMMP13 by MMP14 (MT1-MMP) (Xenopus tropicalis)
Authored
Jupe, S  (2011-09-09)
Reviewed
Butler, GS  (2012-02-28)
Overall, CM  (2012-02-28)
Created
Jupe, S  (2011-09-19)
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