Initial activation of proMMP13 by MMP14 (MT1-MMP)

Stable Identifier
R-HSA-1604741
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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MMP14 (MT1-MMP) initially cleaves MMP13 at Gly54-Ile55 (Knauper et al. 1996a, 1996b) followed by autoprocessing at Glu103-Tyr104.

Literature References
PubMed ID Title Journal Year
8663255 Cellular mechanisms for human procollagenase-3 (MMP-13) activation. Evidence that MT1-MMP (MMP-14) and gelatinase a (MMP-2) are able to generate active enzyme

Knäuper, V, Will, H, López-Otin, C, Smith, B, Atkinson, SJ, Stanton, H, Hembry, RM, Murphy, G

J Biol Chem 1996
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
serine-type endopeptidase activity of MMP14 (16) [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created