Autocatalytic activation of proMMP13

Stable Identifier
R-HSA-1604732
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region
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Autocatalytic activation of proMMP13
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Following initial activation autoproteolysis occurs at Glu103-Tyr104 (Knauper et al. 1996a,1996b). This is inhibited by endostatin (Nyberg et al. 2003).

Literature References
PubMed ID Title Journal Year
8576151 Biochemical characterization of human collagenase-3

Knäuper, V, López-Otin, C, Smith, B, Knight, G, Murphy, G

J Biol Chem 1996
8663255 Cellular mechanisms for human procollagenase-3 (MMP-13) activation. Evidence that MT1-MMP (MMP-14) and gelatinase a (MMP-2) are able to generate active enzyme

Knäuper, V, Will, H, López-Otin, C, Smith, B, Atkinson, SJ, Stanton, H, Hembry, RM, Murphy, G

J Biol Chem 1996
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
serine-type endopeptidase activity of MMP13 intermediate forms [extracellular region]
Physical Entity
MMP13 intermediate forms [extracellular region]
Activity
serine-type endopeptidase activity (0004252)
This event is regulated
Negatively by
Orthologous Events
Autocatalytic activation of proMMP13 (Canis familiaris)
Autocatalytic activation of proMMP13 (Danio rerio)
Autocatalytic activation of proMMP13 (Gallus gallus)
Autocatalytic activation of proMMP13 (Mus musculus)
Autocatalytic activation of proMMP13 (Rattus norvegicus)
Autocatalytic activation of proMMP13 (Sus scrofa)
Autocatalytic activation of proMMP13 (Xenopus tropicalis)
Authored
Jupe, S  (2011-09-09)
Reviewed
Butler, GS  (2012-02-28)
Overall, CM  (2012-02-28)
Created
Jupe, S  (2011-09-19)
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