Autocatalytic activation of proMMP13

Stable Identifier
R-HSA-1604732
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Following initial activation autoproteolysis occurs at Glu103-Tyr104 (Knauper et al. 1996a,1996b). This is inhibited by endostatin (Nyberg et al. 2003).

Literature References
PubMed ID Title Journal Year
8576151 Biochemical characterization of human collagenase-3

Knäuper, V, López-Otin, C, Smith, B, Knight, G, Murphy, G

J Biol Chem 1996
8663255 Cellular mechanisms for human procollagenase-3 (MMP-13) activation. Evidence that MT1-MMP (MMP-14) and gelatinase a (MMP-2) are able to generate active enzyme

Knäuper, V, Will, H, López-Otin, C, Smith, B, Atkinson, SJ, Stanton, H, Hembry, RM, Murphy, G

J Biol Chem 1996
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
serine-type endopeptidase activity of MMP13 intermediate forms [extracellular region]
Physical Entity
Activity
This event is regulated
Orthologous Events
Authored
Reviewed
Created