Reactome | Autocatalytic activation of proMMP13

Autocatalytic activation of proMMP13

Stable Identifier

R-HSA-1604732

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region

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Following initial activation autoproteolysis occurs at Glu103-Tyr104 (Knauper et al. 1996a,1996b). This is inhibited by endostatin (Nyberg et al. 2003).

Literature References

PubMed ID	Title	Journal	Year
8576151	Biochemical characterization of human collagenase-3 Knäuper, V, López-Otin, C, Smith, B, Knight, G, Murphy, G	J Biol Chem	1996
8663255	Cellular mechanisms for human procollagenase-3 (MMP-13) activation. Evidence that MT1-MMP (MMP-14) and gelatinase a (MMP-2) are able to generate active enzyme Knäuper, V, Will, H, López-Otin, C, Smith, B, Atkinson, SJ, Stanton, H, Hembry, RM, Murphy, G	J Biol Chem	1996