Reactome | Autocatalytic activation of proMMP13

Autocatalytic activation of proMMP13

Stable Identifier

R-HSA-1604732

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region

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Following initial activation autoproteolysis occurs at Glu103-Tyr104 (Knauper et al. 1996a,1996b). This is inhibited by endostatin (Nyberg et al. 2003).

Literature References

PubMed ID	Title	Journal	Year
8663255	Cellular mechanisms for human procollagenase-3 (MMP-13) activation. Evidence that MT1-MMP (MMP-14) and gelatinase a (MMP-2) are able to generate active enzyme Atkinson, SJ, Smith, B, López-Otin, C, Hembry, RM, Knäuper, V, Murphy, G, Will, H, Stanton, H	J Biol Chem	1996
8576151	Biochemical characterization of human collagenase-3 Smith, B, López-Otin, C, Knight, G, Knäuper, V, Murphy, G	J Biol Chem	1996