Reactome | Activation of proMMP9 by proteases

Activation of proMMP9 by proteases

Stable Identifier

R-HSA-1604722

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

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proMMP9 can be activated by trypsin and chymotrypsin (Sopata & Dancewicz 1974), tissue kallikrein (Tschesche et al. 1989, Desrivieres et al. 1993), cathepsin G (Murphy et al. 1980), and trypsin-2 (Sorsa et al. 1997). This appears to be a one-step activation; the single peptide bond cleaved by trypsin-2 in proMMP-9 is Arg106-Phe107. Modes of activation by other proteases are unclear. Activation is inhibited by endostatin (Nyberg et al. 2003).

Literature References

PubMed ID	Title	Journal	Year
2557753	Tissue kallikrein effectively activates latent matrix degrading metalloenzymes Oberhoff, R, Tschesche, H, Michaelis, J, Fedrowitz, J, Kohnert, U	Adv Exp Med Biol	1989
9261109	Activation of type IV procollagenases by human tumor-associated trypsin-2 Sorsa, T, Tuuttila, A, Bergmann, U, Salo, T, Teronen, O, Koivunen, E, Leinonen, J, Tschesche, H, Tyynelä, J, Konttinen, YT, Heikkilä, P, Stenman, UH, Niemi, E, Osman, S	J Biol Chem	1997
4216367	Presence of a gelatin-specific proteinase and its latent form in human leucocytes Sopata, I, Dancewicz, AM	Biochim Biophys Acta	1974
6263256	The latent collagenase and gelatinase of human polymorphonuclear neutrophil leucocytes Baggiolini, M, Bretz, U, Reynolds, JJ, Murphy, G	Biochem J	1980