Initial activation of proMMP7 by trypsin

Stable Identifier
R-HSA-1604712
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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proMMP7 (proMatrilysin-1) activation by trypsin occurs via an intermediate cleaved at Lys50-Asn51 which undergoes autocatalysis (Crabbe et al. 1992). Leukocyte elastase and plasmin partially activate MMP7 by an uncharacterized mechanism. Highly sulfated glycosaminoglycans (GAG), such as heparin, chondroitin-4,6-sulfate (CS-E), and dermatan sulfate, markedly enhance (>50-fold) the intermolecular autolytic activation of promatrilysin and the activity of fully active matrilysin (Ra et al. 2009).

Literature References
PubMed ID Title Journal Year
1390635 Biochemical characterization of matrilysin. Activation conforms to the stepwise mechanisms proposed for other matrix metalloproteinases

Crabbe, T, Willenbrock, F, Eaton, D, Hynds, P, Carne, AF, Murphy, G, Docherty, AJ

Biochemistry 1992
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
serine-type endopeptidase activity of MMP7 initial activators [extracellular region]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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