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MTMR2 [cytosol]
Stable Identifier
R-HSA-1604662
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
KIAA1073
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Phospholipid metabolism (Homo sapiens)
PI Metabolism (Homo sapiens)
Synthesis of PIPs at the ER membrane (Homo sapiens)
PI(3,5)P2 is dephosphorylated to PI5P by MTMR2:SBF1 (Homo sapiens)
MTMR2:SBF1 [endoplasmic reticulum membrane] (Homo sapiens)
MTMR2 [cytosol] (Homo sapiens)
PI3P is dephosphorylated to PI by MTMR2:SBF1 (Homo sapiens)
MTMR2:SBF1 [endoplasmic reticulum membrane] (Homo sapiens)
MTMR2 [cytosol] (Homo sapiens)
SBF1 binds MTMR2 (Homo sapiens)
MTMR2 [cytosol] (Homo sapiens)
MTMR2:SBF1 [endoplasmic reticulum membrane] (Homo sapiens)
MTMR2 [cytosol] (Homo sapiens)
Synthesis of PIPs at the early endosome membrane (Homo sapiens)
MTMR12 binds MTMR2 (Homo sapiens)
MTMR2 [cytosol] (Homo sapiens)
MTMR2:MTMR12 [cytosol] (Homo sapiens)
MTMR2 [cytosol] (Homo sapiens)
MTMR2 binds MTMR10 (Homo sapiens)
MTMR2 [cytosol] (Homo sapiens)
MTMR2:MTMR10 [cytosol] (Homo sapiens)
MTMR2 [cytosol] (Homo sapiens)
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the early endosome membrane (Homo sapiens)
MTM1,MTMR2,MTMR4 [cytosol] (Homo sapiens)
MTMR2 [cytosol] (Homo sapiens)
PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane (Homo sapiens)
MTM1,MTMR2,MTMR4 [cytosol] (Homo sapiens)
MTMR2 [cytosol] (Homo sapiens)
Synthesis of PIPs at the late endosome membrane (Homo sapiens)
PI(3,5)P2 is dephosphorylated to PI5P by MTM proteins at the late endosome membrane (Homo sapiens)
MTM1,MTMR2,MTMR4,MTMR7 [cytosol] (Homo sapiens)
MTMR2 [cytosol] (Homo sapiens)
PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane (Homo sapiens)
MTM1,MTMR2,MTMR4,MTMR7 [cytosol] (Homo sapiens)
MTMR2 [cytosol] (Homo sapiens)
Synthesis of PIPs at the plasma membrane (Homo sapiens)
MTMR2 binds SBF2 (Homo sapiens)
MTMR2 homodimer [cytosol] (Homo sapiens)
MTMR2 [cytosol] (Homo sapiens)
MTMR2:SBF2 Tetramer [cytosol] (Homo sapiens)
MTMR2 homodimer [cytosol] (Homo sapiens)
MTMR2 [cytosol] (Homo sapiens)
MTMR2 dimerizes (Homo sapiens)
MTMR2 [cytosol] (Homo sapiens)
MTMR2 homodimer [cytosol] (Homo sapiens)
MTMR2 [cytosol] (Homo sapiens)
PI(3,5)P2 is dephosphorylated to PI5P by the MTMR2:SBF2 tetramer at the plasma membrane (Homo sapiens)
MTMR2:SBF2 Tetramer [cytosol] (Homo sapiens)
MTMR2 homodimer [cytosol] (Homo sapiens)
MTMR2 [cytosol] (Homo sapiens)
PI3P is dephosphorylated to PI by the MTMR2:SBF2 tetramer at the plasma membrane (Homo sapiens)
MTMR2:SBF2 Tetramer [cytosol] (Homo sapiens)
MTMR2 homodimer [cytosol] (Homo sapiens)
MTMR2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13614 MTMR2
Gene Names
MTMR2, KIAA1073
Chain
chain:1-643
Reference Genes
BioGPS Gene:8898 MTMR2
COSMIC (genes):MTMR2 MTMR2
CTD Gene:8898 MTMR2
dbSNP Gene:8898 MTMR2
ENSEMBL:ENSG00000087053 MTMR2
HGNC:7450 MTMR2
KEGG:hsa:8898 MTMR2
Monarch:8898 MTMR2
NCBI Gene:8898 MTMR2
OMIM:603557 MTMR2
UCSC:Q13614 MTMR2
Reference Transcript
RefSeq:XM_017018518.1 MTMR2
RefSeq:XM_006718935.2 MTMR2
RefSeq:NM_016156.5 MTMR2
RefSeq:NM_001243571.1 MTMR2
RefSeq:XM_006718936.3 MTMR2
RefSeq:XM_005274375.2 MTMR2
RefSeq:XM_005274374.2 MTMR2
RefSeq:NM_201278.2 MTMR2
RefSeq:NM_201281.2 MTMR2
RefSeq:XM_006718934.2 MTMR2
RefSeq:XM_017018517.1 MTMR2
Other Identifiers
11732292_a_at
11732293_a_at
11736170_a_at
11739550_a_at
11763034_at
11763860_s_at
16743483
203211_PM_s_at
203211_s_at
203212_PM_s_at
203212_s_at
214649_PM_s_at
214649_s_at
224417_PM_at
224417_at
33277_at
3387464
3387466
3387467
3387468
3387470
3387471
3387472
3387474
3387476
3387478
3387480
3387482
3387484
3387485
3387486
3387487
3387488
3387489
3387491
3387492
3387496
3387497
3387498
3387499
3387500
3387501
3387502
3387503
3387504
3387505
3387506
3387507
3387508
3387511
3387512
3387513
3387514
3387519
3387520
3387524
3387525
3387526
3387527
3387528
51213_at
7951108
7951112
82490_at
8898
A_23_P64019
A_24_P406830
GE61868
GE883976
GO:0002091
GO:0003824
GO:0004438
GO:0005515
GO:0005634
GO:0005737
GO:0005768
GO:0005774
GO:0005829
GO:0006629
GO:0006661
GO:0008021
GO:0014069
GO:0016020
GO:0016311
GO:0016787
GO:0030424
GO:0030425
GO:0031410
GO:0031642
GO:0031901
GO:0032288
GO:0042552
GO:0042802
GO:0042995
GO:0043197
GO:0043226
GO:0043231
GO:0045806
GO:0046488
GO:0046856
GO:0048471
GO:0048666
GO:0048856
GO:0052629
GO:0052866
GO:0060304
GO:0070062
GO:0090394
GO:0097060
GO:0097062
GO:0106018
GO:2000643
GO:2000645
HMNXSV003034359
Hs.181326.0.S1_3p_a_at
Hs.278491.0.S2_3p_s_at
ILMN_1659952
ILMN_2351029
PH_hs_0010729
TC11002209.hg
TC11003301.hg
TC11003302.hg
U58033_at
g13605771_3p_at
g7705563_3p_a_at
p28632
Participates
as a component of
MTMR2:MTMR12 [cytosol] (Homo sapiens)
MTMR2:MTMR10 [cytosol] (Homo sapiens)
MTMR2 homodimer [cytosol] (Homo sapiens)
MTMR2:SBF1 [endoplasmic reticulum membrane] (Homo sapiens)
as an input of
MTMR12 binds MTMR2 (Homo sapiens)
MTMR2 binds MTMR10 (Homo sapiens)
MTMR2 dimerizes (Homo sapiens)
SBF1 binds MTMR2 (Homo sapiens)
as a member of
MTM1,MTMR2,MTMR4,MTMR7 [cytosol] (Homo sapiens)
MTM1,MTMR2,MTMR4 [cytosol] (Homo sapiens)
Inferred To
YMR1 [cytosol]
(Saccharomyces cerevisiae)
MTMR2 [cytosol]
(Bos taurus)
MTMR2 [cytosol]
(Caenorhabditis elegans)
MTMR2 [cytosol]
(Canis familiaris)
MTMR2 [cytosol]
(Danio rerio)
MTMR2 [cytosol]
(Dictyostelium discoideum)
MTMR2 [cytosol]
(Drosophila melanogaster)
MTMR2 [cytosol]
(Gallus gallus)
MTMR2 [cytosol]
(Schizosaccharomyces pombe)
MTMR2 [cytosol]
(Sus scrofa)
Mtmr2 [cytosol]
(Mus musculus)
Mtmr2 [cytosol]
(Rattus norvegicus)
Homologues of MTMR2 [cytosol]
(Dictyostelium discoideum)
Cross References
RefSeq
XP_005274432.1
,
NP_958438.1
,
XP_005274431.1
,
XP_006718999.1
,
XP_006718998.1
,
XP_016874006.1
,
NP_958435.1
,
NP_057240.3
,
XP_016874007.1
,
XP_006718997.1
,
NP_001230500.1
OpenTargets
ENSG00000087053
ENSEMBL
ENST00000481642
,
ENST00000674968
,
ENSP00000502032
,
ENST00000484818
,
ENST00000346299
,
ENST00000409459
,
ENST00000676166
,
ENSP00000501567
,
ENSP00000501601
,
ENST00000675652
,
ENST00000675477
,
ENSP00000501867
,
ENST00000495134
,
ENSP00000502736
,
ENST00000675933
,
ENST00000675636
,
ENSP00000502515
,
ENST00000676378
,
ENST00000675981
,
ENSP00000501926
,
ENST00000675489
,
ENSP00000502204
,
ENSP00000501675
,
ENSP00000501753
,
ENST00000674610
,
ENST00000444541
,
ENSP00000502505
,
ENST00000676440
,
ENSP00000396020
,
ENSP00000502829
,
ENST00000497683
,
ENSP00000345752
,
ENST00000674989
,
ENST00000676261
,
ENST00000674528
,
ENST00000674924
,
ENSP00000501781
,
ENSP00000502694
,
ENSP00000502433
,
ENSP00000502575
,
ENST00000352297
,
ENST00000675454
,
ENSP00000501688
,
ENSP00000501963
,
ENSP00000501702
,
ENST00000470293
,
ENSP00000501850
,
ENSP00000501989
,
ENSP00000501751
,
ENSP00000501894
,
ENSP00000502567
,
ENSP00000501632
,
ENSP00000386882
,
ENST00000675174
,
ENST00000675196
,
ENST00000393223
,
ENSP00000376915
,
ENST00000676272
,
ENSP00000343737
,
ENST00000675362
HPA
ENSG00000087053-MTMR2
PRO
Q13614
Pharos - Targets
Q13614
GlyGen
Q13614
Orphanet
MTMR2
HMDB Protein
HMDBP11837
PDB
1ZSQ
,
1M7R
,
1ZVR
,
5GNH
,
1LW3
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9C0I1 MTMR12
1
MTMR12 [cytosol]
(R-HSA-6809657)
0.688
3
UniProt:O60826 CCDC22
2
CCDC22 [nucleoplasm]
(R-HSA-8955644)
CCDC22 [cytosol]
(R-HSA-8955640)
0.643
5
UniProt:Q86WG5 SBF2
1
SBF2 [cytosol]
(R-HSA-6809792)
0.569
4
UniProt:Q96QG7 MTMR9
1
MTMR9 [cytosol]
(R-HSA-6809239)
0.527
2
UniProt:Q9NXD2 MTMR10
1
MTMR10 [cytosol]
(R-HSA-6810028)
0.527
2
UniProt:O95248 SBF1
2
SBF1 [cytosol]
(R-HSA-8876843)
SBF1 [endoplasmic reticulum membrane]
(R-HSA-6809747)
0.527
2
UniProt:Q13613 MTMR1
1
MTMR1 [cytosol]
(R-HSA-1604647)
0.527
3
UniProt:P07196 NEFL
1
NEFL [cytosol]
(R-HSA-432284)
0.508
2
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