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SYNJ1 [cytosol]
Stable Identifier
R-HSA-1604634
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
KIAA0910
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Inositol phosphate metabolism (Homo sapiens)
Synthesis of IP2, IP, and Ins in the cytosol (Homo sapiens)
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Homo sapiens)
INPP5(4) [cytosol] (Homo sapiens)
SYNJ1 [cytosol] (Homo sapiens)
Synthesis of IP3 and IP4 in the cytosol (Homo sapiens)
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol (Homo sapiens)
INPP5(3)/ITPK1 [cytosol] (Homo sapiens)
SYNJ1 [cytosol] (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Phospholipid metabolism (Homo sapiens)
PI Metabolism (Homo sapiens)
Synthesis of PIPs at the plasma membrane (Homo sapiens)
PI(3,5)P2 is dephosphorylated to PI3P by SYNJ at the plasma membrane (Homo sapiens)
SYNJs,OCRL [cytosol] (Homo sapiens)
SYNJ1 [cytosol] (Homo sapiens)
PI(3,5)P2 is dephosphorylated to PI5P by SYNJ/MTMs at the plasma membrane (Homo sapiens)
MTM1,MTMR1,MTMR3,MTMR6,MTMR14,SYNJ1,SYNJ2 [cytosol] (Homo sapiens)
SYNJ1 [cytosol] (Homo sapiens)
PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane (Homo sapiens)
SYNJ/INPP5(1) [cytosol] (Homo sapiens)
SYNJ1 [cytosol] (Homo sapiens)
PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane (Homo sapiens)
MTM1,MTMR1,MTMR3,MTMR6,MTMR14,SYNJ1,SYNJ2 [cytosol] (Homo sapiens)
SYNJ1 [cytosol] (Homo sapiens)
PI4P is dephosphorylated to PI by SYNJ at the plasma membrane (Homo sapiens)
SYNJs,OCRL [cytosol] (Homo sapiens)
SYNJ1 [cytosol] (Homo sapiens)
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Clathrin-mediated endocytosis (Homo sapiens)
Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
SYNJs,OCRL [cytosol] (Homo sapiens)
SYNJ1 [cytosol] (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
SYNJs,OCRL [cytosol] (Homo sapiens)
SYNJ1 [cytosol] (Homo sapiens)
Clathrin recruits auxilins to the clathrin-coated vesicle (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
SYNJs,OCRL [cytosol] (Homo sapiens)
SYNJ1 [cytosol] (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
SYNJs,OCRL [cytosol] (Homo sapiens)
SYNJ1 [cytosol] (Homo sapiens)
Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
SYNJs,OCRL [cytosol] (Homo sapiens)
SYNJ1 [cytosol] (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
SYNJs,OCRL [cytosol] (Homo sapiens)
SYNJ1 [cytosol] (Homo sapiens)
Dissociation of clathrin-associated proteins (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
SYNJs,OCRL [cytosol] (Homo sapiens)
SYNJ1 [cytosol] (Homo sapiens)
SYNJs,OCRL [cytosol] (Homo sapiens)
SYNJ1 [cytosol] (Homo sapiens)
Dynamin-mediated GTP hydrolysis promotes vesicle scission (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
SYNJs,OCRL [cytosol] (Homo sapiens)
SYNJ1 [cytosol] (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
SYNJs,OCRL [cytosol] (Homo sapiens)
SYNJ1 [cytosol] (Homo sapiens)
Endophilins recruit synaptojanins to the clathrin-coated pit (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
SYNJs,OCRL [cytosol] (Homo sapiens)
SYNJ1 [cytosol] (Homo sapiens)
SYNJs,OCRL [cytosol] (Homo sapiens)
SYNJ1 [cytosol] (Homo sapiens)
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
SYNJs,OCRL [cytosol] (Homo sapiens)
SYNJ1 [cytosol] (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
SYNJs,OCRL [cytosol] (Homo sapiens)
SYNJ1 [cytosol] (Homo sapiens)
RAB5 and GAPVD1 bind AP-2 (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
SYNJs,OCRL [cytosol] (Homo sapiens)
SYNJ1 [cytosol] (Homo sapiens)
SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Homo sapiens)
PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
SYNJs,OCRL [cytosol] (Homo sapiens)
SYNJ1 [cytosol] (Homo sapiens)
PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
SYNJs,OCRL [cytosol] (Homo sapiens)
SYNJ1 [cytosol] (Homo sapiens)
SYNJs,OCRL [cytosol] (Homo sapiens)
SYNJ1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O43426 SYNJ1
Gene Names
SYNJ1, KIAA0910
Chain
chain:1-1573
Reference Genes
BioGPS Gene:8867 SYNJ1
COSMIC (genes):SYNJ1 SYNJ1
CTD Gene:8867 SYNJ1
dbSNP Gene:8867 SYNJ1
ENSEMBL:ENSG00000159082.18 SYNJ1
HGNC:11503 SYNJ1
KEGG Gene (Homo sapiens):8867 SYNJ1
Monarch:8867 SYNJ1
NCBI Gene:8867 SYNJ1
OMIM:604297 SYNJ1
UCSC:O43426 SYNJ1
Reference Transcript
RefSeq:XM_017028500.1 SYNJ1
RefSeq:NM_203446.2 SYNJ1
RefSeq:NM_003895.3 SYNJ1
RefSeq:NM_001160306.1 SYNJ1
RefSeq:NM_001160302.1 SYNJ1
Other Identifiers
0002230671
0004010609
11723867_a_at
11723868_a_at
11745278_a_at
11745279_a_at
16925057
207594_PM_s_at
207594_s_at
212990_PM_at
212990_at
3929326
3929327
3929328
3929329
3929330
3929331
3929332
3929334
3929335
3929336
3929337
3929339
3929341
3929342
3929343
3929344
3929346
3929347
3929348
3929350
3929351
3929354
3929357
3929360
3929361
3929362
3929364
3929366
3929367
3929368
3929372
3929373
3929374
3929377
3929379
3929380
3929381
3929382
3929384
3929385
3929386
3929389
3929390
41692_at
8070010
8867
A_23_P102884
A_23_P324718
GE53578
GE81333
GE86488
GO:0003676
GO:0003723
GO:0003824
GO:0004438
GO:0004439
GO:0005622
GO:0005737
GO:0005829
GO:0005856
GO:0005874
GO:0005886
GO:0005975
GO:0006629
GO:0006661
GO:0006836
GO:0006897
GO:0007420
GO:0007612
GO:0008022
GO:0012506
GO:0014015
GO:0016082
GO:0016191
GO:0016192
GO:0016787
GO:0016791
GO:0017124
GO:0023052
GO:0030117
GO:0030132
GO:0030154
GO:0032526
GO:0032991
GO:0034097
GO:0034595
GO:0034596
GO:0036092
GO:0043005
GO:0043195
GO:0043226
GO:0043647
GO:0043812
GO:0043813
GO:0044877
GO:0046488
GO:0046855
GO:0046856
GO:0048260
GO:0048471
GO:0048488
GO:0048489
GO:0048856
GO:0050877
GO:0052629
GO:0052658
GO:0052866
GO:0061024
GO:0065003
GO:0097060
GO:0098688
GO:0098793
GO:1904980
GO:1990175
HMNXSV003041692
HMNXSV003048451
Hs.127416.2.S1_3p_at
ILMN_1683647
ILMN_1701991
ILMN_1762303
ILMN_2393968
PH_hs_0019097
TC21000400.hg
g4507334_3p_a_at
Participates
as a member of
INPP5(4) [cytosol] (Homo sapiens)
INPP5(3)/ITPK1 [cytosol] (Homo sapiens)
SYNJs,OCRL [cytosol] (Homo sapiens)
MTM1,MTMR1,MTMR3,MTMR6,MTMR14,SYNJ1,SYNJ2 [cytosol] (Homo sapiens)
SYNJ/INPP5(1) [cytosol] (Homo sapiens)
Inferred To
Synj [cytosol]
(Drosophila melanogaster)
Homologues of SYNJ1 [cytosol]
(Plasmodium falciparum)
INP52 [cytosol]
(Saccharomyces cerevisiae)
syj1 [cytosol]
(Schizosaccharomyces pombe)
synj1 [cytosol]
(Xenopus tropicalis)
Dd5P3 [cytosol]
(Dictyostelium discoideum)
unc-26 [cytosol]
(Caenorhabditis elegans)
Synj1 [cytosol]
(Mus musculus)
Synj1 [cytosol]
(Rattus norvegicus)
SYNJ1 [cytosol]
(Bos taurus)
SYNJ1 [cytosol]
(Canis familiaris)
SYNJ1 [cytosol]
(Danio rerio)
SYNJ1 [cytosol]
(Gallus gallus)
SYNJ1 [cytosol]
(Plasmodium falciparum)
SYNJ1 [cytosol]
(Sus scrofa)
Cross References
RefSeq
XP_016883989.1
,
NP_001153778.1
,
NP_003886.3
,
NP_001153774.1
,
NP_982271.2
Guide to Pharmacology - Targets
1461
OpenTargets
ENSG00000159082
HPA
ENSG00000159082-SYNJ1
GeneCards
O43426
Ensembl
ENSP00000501530
,
ENST00000357345
,
ENSG00000159082
,
ENST00000674204
,
ENST00000674351
,
ENSP00000349903
,
ENSP00000501504
,
ENSP00000501426
,
ENST00000674308
PRO
O43426
Pharos - Targets
O43426
Orphanet
22665
HMDB Protein
HMDBP01573
PDB
2DNR
,
2VJ0
,
1W80
,
7A0V
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P62994 Grb2
3
Grb2 [cytosol]
(R-RNO-55929)
Grb2 [plasma membrane]
(R-RNO-202993)
Grb2 [cytosol]
(R-RNO-74686)
0.558
2
UniProt:Q99962 SH3GL2
4
SH3GL2 [cytosol]
(R-HSA-182958)
SH3GL2 [plasma membrane]
(R-HSA-177495)
SH3GL2 [clathrin-coated endocytic vesicle membrane]
(R-HSA-2130629)
SH3GL2 [Golgi membrane]
(R-HSA-351189)
0.558
2
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.527
2
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