Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
ITPKA [cytosol]
Stable Identifier
R-HSA-1604604
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Inositol phosphate metabolism (Homo sapiens)
Synthesis of IP3 and IP4 in the cytosol (Homo sapiens)
I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol (Homo sapiens)
ITPKA/B/C [cytosol] (Homo sapiens)
ITPKA:Ca2+:CALM1 [cytosol] (Homo sapiens)
ITPKA [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P23677 ITPKA
Gene Names
ITPKA
Chain
chain:1-461
Reference Genes
BioGPS Gene:3706 ITPKA
COSMIC (genes):ITPKA ITPKA
CTD Gene:3706 ITPKA
dbSNP Gene:3706 ITPKA
ENSEMBL:ENSG00000137825 ITPKA
HGNC:6178 ITPKA
KEGG:hsa:3706 ITPKA
Monarch:3706 ITPKA
NCBI Gene:3706 ITPKA
OMIM:147521 ITPKA
UCSC:P23677 ITPKA
Reference Transcript
RefSeq:NM_002220.3 ITPKA
Other Identifiers
11727347_at
118_at
16799839
205874_PM_at
205874_at
3590469
3590470
3590471
3590472
3590473
3590477
3590478
3590479
3590480
3590481
3590482
3590483
3590484
3590485
3590486
3706
7982927
A_14_P103425
A_23_P65918
GE59800
GO:0000828
GO:0003824
GO:0004683
GO:0005516
GO:0005524
GO:0005634
GO:0005737
GO:0005829
GO:0005856
GO:0006020
GO:0006629
GO:0007010
GO:0007165
GO:0008440
GO:0016301
GO:0016740
GO:0019637
GO:0030036
GO:0031267
GO:0032958
GO:0034330
GO:0043197
GO:0043226
GO:0046854
GO:0048167
GO:0051592
GO:0061003
GO:0071277
GO:0097062
GO:0098871
GO:0098885
GO:0098978
GO:0140096
GO:0180030
HMNXSV003010788
ILMN_1776516
PH_hs_0000354
TC15000309.hg
X54938_at
g4504788_3p_at
Participates
as a component of
ITPKA:Ca2+:CALM1 [cytosol] (Homo sapiens)
Inferred To
IP3K2 [cytosol]
(Drosophila melanogaster)
Homologues of ITPKA [cytosol]
(Drosophila melanogaster)
IP3K1 [cytosol]
(Drosophila melanogaster)
Itpka [cytosol]
(Mus musculus)
Itpka [cytosol]
(Rattus norvegicus)
ITPKA [cytosol]
(Bos taurus)
ITPKA [cytosol]
(Canis familiaris)
ITPKA [cytosol]
(Dictyostelium discoideum)
ITPKA [cytosol]
(Gallus gallus)
ITPKA [cytosol]
(Plasmodium falciparum)
ITPKA [cytosol]
(Sus scrofa)
lfe-2 [cytosol]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_002211.1
Guide to Pharmacology - Targets
1447
ENSEMBL
ENSG00000137825
,
ENSP00000260386
,
ENST00000260386
OpenTargets
ENSG00000137825
IntEnz
2.7.1.127
GeneCards
ITPKA
HPA
ENSG00000137825-ITPKA
PRO
P23677
Pharos - Targets
P23677
HMDB Protein
HMDBP00984
PDB
1W2D
,
1W2F
,
1W2C
,
8PPF
,
8PPD
,
8PPG
,
8PPE
,
8PPB
,
8PP9
,
8PPH
,
8PPC
,
8PPA
,
8PPI
,
8PPJ
,
4UPU
,
8PP8
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text