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DTX4
Stable Identifier
R-HSA-1604439
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Protein deltex-4
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Cytosolic sensors of pathogen-associated DNA (Homo sapiens)
Regulation of innate immune responses to cytosolic DNA (Homo sapiens)
DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3 (Homo sapiens)
DTX4 [cytosol] (Homo sapiens)
NLRP4:DTX4:STING:p-S172-TBK1:IRF3 [cytoplasmic vesicle membrane] (Homo sapiens)
DTX4 [cytosol] (Homo sapiens)
DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:dsDNA:ZBP1:TBK1 (Homo sapiens)
DTX4 [cytosol] (Homo sapiens)
NLRP4:DTX4:dsDNA:ZBP1:pS-172-TBK1 [cytosol] (Homo sapiens)
DTX4 [cytosol] (Homo sapiens)
NLRP4 and DTX4 associate with p-S172-TBK1 within STING:TBK1:IRF3 (Homo sapiens)
DTX4 [cytosol] (Homo sapiens)
NLRP4:DTX4:STING:p-S172-TBK1:IRF3 [cytoplasmic vesicle membrane] (Homo sapiens)
DTX4 [cytosol] (Homo sapiens)
NLRP4 and DTX4 associate with p-S172-TBK1 within dsDNA:ZBP1:TBK1 (Homo sapiens)
DTX4 [cytosol] (Homo sapiens)
NLRP4:DTX4:dsDNA:ZBP1:pS-172-TBK1 [cytosol] (Homo sapiens)
DTX4 [cytosol] (Homo sapiens)
STING mediated induction of host immune responses (Homo sapiens)
IRF3-mediated induction of type I IFN (Homo sapiens)
IRF3 is phosphorylated by TBK1 (Homo sapiens)
NLRP4:DTX4:STING:p-S172-TBK1:IRF3 [cytoplasmic vesicle membrane] (Homo sapiens)
DTX4 [cytosol] (Homo sapiens)
ZBP1(DAI) mediated induction of type I IFNs (Homo sapiens)
IRF3 mediated activation of type 1 IFN (Homo sapiens)
Phosphorylation and release of IRF3 (Homo sapiens)
NLRP4:DTX4:dsDNA:ZBP1:pS-172-TBK1 [cytosol] (Homo sapiens)
DTX4 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH1 (Homo sapiens)
Activated NOTCH1 Transmits Signal to the Nucleus (Homo sapiens)
ARRB mediates NOTCH1 ubiquitination (Homo sapiens)
NOTCH1:DTX:ARRB [plasma membrane] (Homo sapiens)
NOTCH1:DTX [plasma membrane] (Homo sapiens)
DTX [cytosol] (Homo sapiens)
DTX4 [cytosol] (Homo sapiens)
Ub-NOTCH1:DTX:ARRB [plasma membrane] (Homo sapiens)
NOTCH1:DTX:ARRB [plasma membrane] (Homo sapiens)
NOTCH1:DTX [plasma membrane] (Homo sapiens)
DTX [cytosol] (Homo sapiens)
DTX4 [cytosol] (Homo sapiens)
Cleavage of CNTN1:NOTCH1 complex releases NICD1 (Homo sapiens)
CNTN1:NOTCH1:DTX [plasma membrane] (Homo sapiens)
NOTCH1:DTX [plasma membrane] (Homo sapiens)
DTX [cytosol] (Homo sapiens)
DTX4 [cytosol] (Homo sapiens)
NICD1:DTX [cytosol] (Homo sapiens)
DTX [cytosol] (Homo sapiens)
DTX4 [cytosol] (Homo sapiens)
Cleavage of DNER:NOTCH1 complex releases NICD1 (Homo sapiens)
DNER:NOTCH1:DTX [plasma membrane] (Homo sapiens)
NOTCH1:DTX [plasma membrane] (Homo sapiens)
DTX [cytosol] (Homo sapiens)
DTX4 [cytosol] (Homo sapiens)
NICD1:DTX [cytosol] (Homo sapiens)
DTX [cytosol] (Homo sapiens)
DTX4 [cytosol] (Homo sapiens)
Contactin-1 (CNTN1) binds NOTCH1 (Homo sapiens)
CNTN1:NOTCH1:DTX [plasma membrane] (Homo sapiens)
NOTCH1:DTX [plasma membrane] (Homo sapiens)
DTX [cytosol] (Homo sapiens)
DTX4 [cytosol] (Homo sapiens)
NOTCH1:DTX [plasma membrane] (Homo sapiens)
DTX [cytosol] (Homo sapiens)
DTX4 [cytosol] (Homo sapiens)
DTX binds NOTCH1 (Homo sapiens)
DTX [cytosol] (Homo sapiens)
DTX4 [cytosol] (Homo sapiens)
NOTCH1:DTX [plasma membrane] (Homo sapiens)
DTX [cytosol] (Homo sapiens)
DTX4 [cytosol] (Homo sapiens)
DTX recruits beta-arrestin (ARRB) to NOTCH (Homo sapiens)
NOTCH1:DTX [plasma membrane] (Homo sapiens)
DTX [cytosol] (Homo sapiens)
DTX4 [cytosol] (Homo sapiens)
NOTCH1:DTX:ARRB [plasma membrane] (Homo sapiens)
NOTCH1:DTX [plasma membrane] (Homo sapiens)
DTX [cytosol] (Homo sapiens)
DTX4 [cytosol] (Homo sapiens)
ITCH binds DTX (Homo sapiens)
DTX [cytosol] (Homo sapiens)
DTX4 [cytosol] (Homo sapiens)
DTX:ITCH [cytosol] (Homo sapiens)
DTX [cytosol] (Homo sapiens)
DTX4 [cytosol] (Homo sapiens)
ITCH ubiquitinates DTX (Homo sapiens)
DTX:ITCH [cytosol] (Homo sapiens)
DTX [cytosol] (Homo sapiens)
DTX4 [cytosol] (Homo sapiens)
Ub-DTX:ITCH [cytosol] (Homo sapiens)
DTX [cytosol] (Homo sapiens)
DTX4 [cytosol] (Homo sapiens)
NOTCH1 binds DNER (Homo sapiens)
DNER:NOTCH1:DTX [plasma membrane] (Homo sapiens)
NOTCH1:DTX [plasma membrane] (Homo sapiens)
DTX [cytosol] (Homo sapiens)
DTX4 [cytosol] (Homo sapiens)
NOTCH1:DTX [plasma membrane] (Homo sapiens)
DTX [cytosol] (Homo sapiens)
DTX4 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9Y2E6 DTX4
Gene Names
DTX4, KIAA0937, RNF155
Chain
chain:1-619
Reference Genes
BioGPS Gene:23220 DTX4
COSMIC (genes):DTX4 DTX4
CTD Gene:23220 DTX4
dbSNP Gene:23220 DTX4
ENSEMBL:ENSG00000110042 DTX4
HGNC:29151 DTX4
KEGG Gene (Homo sapiens):hsa:23220 DTX4
Monarch:23220 DTX4
NCBI Gene:23220 DTX4
OMIM:616110 DTX4
UCSC:Q9Y2E6 DTX4
Reference Transcript
RefSeq:NM_001300727.1 DTX4
RefSeq:NM_015177.1 DTX4
RefSeq:XM_006718483.3 DTX4
Other Identifiers
0006100279
11743286_at
16725065
212611_at
23220
35369_at
56760
59294
7940160
A_24_P158718
CCDS44612
CCDS76408
DTX4
DTX4-201
DTX4-204
ENSG00000110042
ENSP00000227451
ENSP00000434055
ENST00000227451
ENST00000532982
EntrezGene:23220
GE53611
GO:0004842
GO:0005737
GO:0005829
GO:0007219
GO:0008270
GO:0016567
GO:0016740
GO:0032479
GO:0046872
HGNC:29151
HPA056760
HPA059294
Hs.523696
Hs.62264.0.S1_3p_at
ILMN_1653678
MIM:616110
NM_001300727
NM_015177
NP_001287656
NP_055992
PF00097
PF02825
PH_hs_0038190
SM00184
SM00678
TC11000484.hg
TC11002686.hg
uc001nnr.3
uc001nns.3
UPI00001C1F00
UPI0000DBE49A
XM_006718483
XP_006718546
Participant Of
input
NLRP4 and DTX4 associate with p-S172-TBK1 within dsDNA:ZBP1:TBK1
NLRP4 and DTX4 associate with p-S172-TBK1 within STING:TBK1:IRF3
hasCandidate
DTX [cytosol]
hasComponent
NLRP4:DTX4:dsDNA:ZBP1:pS-172-TBK1 [cytosol]
NLRP4:DTX4:STING:p-S172-TBK1:IRF3 [cytoplasmic vesicle membrane]
output
DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:dsDNA:ZBP1:TBK1
DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3
Inferred To
Homologues of DTX4 [cytosol] (Danio rerio)
Homologues of DTX4 [cytosol] (Rattus norvegicus)
DTX4 [cytosol] (Bos taurus)
DTX4 [cytosol] (Canis familiaris)
DTX4 [cytosol] (Danio rerio)
DTX4 [cytosol] (Drosophila melanogaster)
DTX4 [cytosol] (Gallus gallus)
DTX4 [cytosol] (Mus musculus)
DTX4 [cytosol] (Rattus norvegicus)
DTX4 [cytosol] (Sus scrofa)
DTX4 [cytosol] (Taeniopygia guttata)
DTX4 [cytosol] (Xenopus tropicalis)
Cross References
RefSeq
NP_001287656.1
,
XP_006718546.1
,
NP_055992.1
Brenda
2.3.2.27
GeneCards
Q9Y2E6
PRO
Q9Y2E6
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