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DTX4 [cytosol]
Stable Identifier
R-HSA-1604439
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Protein deltex-4
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Cytosolic sensors of pathogen-associated DNA (Homo sapiens)
Regulation of innate immune responses to cytosolic DNA (Homo sapiens)
DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3 (Homo sapiens)
DTX4 [cytosol] (Homo sapiens)
NLRP4:DTX4:STING:p-S172-TBK1:IRF3 [cytoplasmic vesicle membrane] (Homo sapiens)
DTX4 [cytosol] (Homo sapiens)
DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:dsDNA:ZBP1:TBK1 (Homo sapiens)
DTX4 [cytosol] (Homo sapiens)
NLRP4:DTX4:dsDNA:ZBP1:pS-172-TBK1 [cytosol] (Homo sapiens)
DTX4 [cytosol] (Homo sapiens)
NLRP4 and DTX4 associate with p-S172-TBK1 within STING:TBK1:IRF3 (Homo sapiens)
DTX4 [cytosol] (Homo sapiens)
NLRP4:DTX4:STING:p-S172-TBK1:IRF3 [cytoplasmic vesicle membrane] (Homo sapiens)
DTX4 [cytosol] (Homo sapiens)
NLRP4 and DTX4 associate with p-S172-TBK1 within dsDNA:ZBP1:TBK1 (Homo sapiens)
DTX4 [cytosol] (Homo sapiens)
NLRP4:DTX4:dsDNA:ZBP1:pS-172-TBK1 [cytosol] (Homo sapiens)
DTX4 [cytosol] (Homo sapiens)
STING mediated induction of host immune responses (Homo sapiens)
IRF3-mediated induction of type I IFN (Homo sapiens)
IRF3 is phosphorylated by TBK1 (Homo sapiens)
NLRP4:DTX4:STING:p-S172-TBK1:IRF3 [cytoplasmic vesicle membrane] (Homo sapiens)
DTX4 [cytosol] (Homo sapiens)
ZBP1(DAI) mediated induction of type I IFNs (Homo sapiens)
IRF3 mediated activation of type 1 IFN (Homo sapiens)
Phosphorylation and release of IRF3 (Homo sapiens)
NLRP4:DTX4:dsDNA:ZBP1:pS-172-TBK1 [cytosol] (Homo sapiens)
DTX4 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH1 (Homo sapiens)
Activated NOTCH1 Transmits Signal to the Nucleus (Homo sapiens)
ARRB mediates NOTCH1 ubiquitination (Homo sapiens)
NOTCH1:DTX:ARRB [plasma membrane] (Homo sapiens)
NOTCH1:DTX [plasma membrane] (Homo sapiens)
DTX [cytosol] (Homo sapiens)
DTX4 [cytosol] (Homo sapiens)
Ub-NOTCH1:DTX:ARRB [plasma membrane] (Homo sapiens)
NOTCH1:DTX:ARRB [plasma membrane] (Homo sapiens)
NOTCH1:DTX [plasma membrane] (Homo sapiens)
DTX [cytosol] (Homo sapiens)
DTX4 [cytosol] (Homo sapiens)
Cleavage of CNTN1:NOTCH1 complex releases NICD1 (Homo sapiens)
CNTN1:NOTCH1:DTX [plasma membrane] (Homo sapiens)
NOTCH1:DTX [plasma membrane] (Homo sapiens)
DTX [cytosol] (Homo sapiens)
DTX4 [cytosol] (Homo sapiens)
NICD1:DTX [cytosol] (Homo sapiens)
DTX [cytosol] (Homo sapiens)
DTX4 [cytosol] (Homo sapiens)
Cleavage of DNER:NOTCH1 complex releases NICD1 (Homo sapiens)
DNER:NOTCH1:DTX [plasma membrane] (Homo sapiens)
NOTCH1:DTX [plasma membrane] (Homo sapiens)
DTX [cytosol] (Homo sapiens)
DTX4 [cytosol] (Homo sapiens)
NICD1:DTX [cytosol] (Homo sapiens)
DTX [cytosol] (Homo sapiens)
DTX4 [cytosol] (Homo sapiens)
Contactin-1 (CNTN1) binds NOTCH1 (Homo sapiens)
CNTN1:NOTCH1:DTX [plasma membrane] (Homo sapiens)
NOTCH1:DTX [plasma membrane] (Homo sapiens)
DTX [cytosol] (Homo sapiens)
DTX4 [cytosol] (Homo sapiens)
NOTCH1:DTX [plasma membrane] (Homo sapiens)
DTX [cytosol] (Homo sapiens)
DTX4 [cytosol] (Homo sapiens)
DTX binds NOTCH1 (Homo sapiens)
DTX [cytosol] (Homo sapiens)
DTX4 [cytosol] (Homo sapiens)
NOTCH1:DTX [plasma membrane] (Homo sapiens)
DTX [cytosol] (Homo sapiens)
DTX4 [cytosol] (Homo sapiens)
DTX recruits beta-arrestin (ARRB) to NOTCH (Homo sapiens)
NOTCH1:DTX [plasma membrane] (Homo sapiens)
DTX [cytosol] (Homo sapiens)
DTX4 [cytosol] (Homo sapiens)
NOTCH1:DTX:ARRB [plasma membrane] (Homo sapiens)
NOTCH1:DTX [plasma membrane] (Homo sapiens)
DTX [cytosol] (Homo sapiens)
DTX4 [cytosol] (Homo sapiens)
ITCH binds DTX (Homo sapiens)
DTX [cytosol] (Homo sapiens)
DTX4 [cytosol] (Homo sapiens)
DTX:ITCH [cytosol] (Homo sapiens)
DTX [cytosol] (Homo sapiens)
DTX4 [cytosol] (Homo sapiens)
ITCH ubiquitinates DTX (Homo sapiens)
DTX:ITCH [cytosol] (Homo sapiens)
DTX [cytosol] (Homo sapiens)
DTX4 [cytosol] (Homo sapiens)
Ub-DTX:ITCH [cytosol] (Homo sapiens)
DTX [cytosol] (Homo sapiens)
DTX4 [cytosol] (Homo sapiens)
NOTCH1 binds DNER (Homo sapiens)
DNER:NOTCH1:DTX [plasma membrane] (Homo sapiens)
NOTCH1:DTX [plasma membrane] (Homo sapiens)
DTX [cytosol] (Homo sapiens)
DTX4 [cytosol] (Homo sapiens)
NOTCH1:DTX [plasma membrane] (Homo sapiens)
DTX [cytosol] (Homo sapiens)
DTX4 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9Y2E6 DTX4
Gene Names
DTX4, KIAA0937, RNF155
Chain
chain:1-619
Reference Genes
BioGPS Gene:23220 DTX4
COSMIC (genes):DTX4 DTX4
CTD Gene:23220 DTX4
dbSNP Gene:23220 DTX4
ENSEMBL:ENSG00000110042 DTX4
HGNC:29151 DTX4
KEGG:hsa:23220 DTX4
Monarch:23220 DTX4
NCBI Gene:23220 DTX4
OMIM:616110 DTX4
UCSC:Q9Y2E6 DTX4
Reference Transcript
RefSeq:NM_015177.1 DTX4
RefSeq:XM_006718483.3 DTX4
RefSeq:NM_001300727.1 DTX4
Other Identifiers
11743286_at
16725065
212611_PM_at
212611_at
23220
3331955
3331956
3331957
3331958
3331959
3331960
3331964
3331965
3331966
3331967
3331969
3331970
3331971
3331972
3331973
3331977
3331978
3331979
3331980
3331982
35369_at
7940160
A_24_P158718
GE53611
GO:0003824
GO:0004842
GO:0005654
GO:0005737
GO:0005813
GO:0005815
GO:0005829
GO:0007219
GO:0008270
GO:0010498
GO:0016567
GO:0016740
GO:0030163
GO:0032479
GO:0043161
GO:0045824
GO:0046872
GO:0061630
GO:0070936
GO:0140096
HMNXSV003040483
Hs.62264.0.S1_3p_at
ILMN_1653678
PH_hs_0038190
TC11000484.hg
TC11002686.hg
Participates
as an input of
NLRP4 and DTX4 associate with p-S172-TBK1 within dsDNA:ZBP1:TBK1 (Homo sapiens)
NLRP4 and DTX4 associate with p-S172-TBK1 within STING:TBK1:IRF3 (Homo sapiens)
as an output of
DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:dsDNA:ZBP1:TBK1 (Homo sapiens)
DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3 (Homo sapiens)
as a component of
NLRP4:DTX4:dsDNA:ZBP1:pS-172-TBK1 [cytosol] (Homo sapiens)
NLRP4:DTX4:STING:p-S172-TBK1:IRF3 [cytoplasmic vesicle membrane] (Homo sapiens)
as a candidate of
DTX [cytosol] (Homo sapiens)
Inferred To
dtx4 [cytosol]
(Xenopus tropicalis)
dtx4a [cytosol]
(Danio rerio)
dx [cytosol]
(Drosophila melanogaster)
Dtx4 [cytosol]
(Mus musculus)
Dtx4 [cytosol]
(Rattus norvegicus)
DTX4 [cytosol]
(Bos taurus)
DTX4 [cytosol]
(Canis familiaris)
DTX4 [cytosol]
(Gallus gallus)
DTX4 [cytosol]
(Sus scrofa)
Cross References
ENSEMBL
ENST00000227451
,
ENSP00000227451
,
ENSG00000110042
,
ENST00000532982
,
ENSP00000434055
OpenTargets
ENSG00000110042
GeneCards
DTX4
HPA
ENSG00000110042-DTX4
PRO
Q9Y2E6
Pharos - Targets
Q9Y2E6
GlyGen
Q9Y2E6
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