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DTX1 [cytosol]
Stable Identifier
R-HSA-1604437
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Protein deltex-1
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH1 (Homo sapiens)
Activated NOTCH1 Transmits Signal to the Nucleus (Homo sapiens)
ARRB mediates NOTCH1 ubiquitination (Homo sapiens)
NOTCH1:DTX:ARRB [plasma membrane] (Homo sapiens)
NOTCH1:DTX [plasma membrane] (Homo sapiens)
DTX [cytosol] (Homo sapiens)
DTX1 [cytosol] (Homo sapiens)
Ub-NOTCH1:DTX:ARRB [plasma membrane] (Homo sapiens)
NOTCH1:DTX:ARRB [plasma membrane] (Homo sapiens)
NOTCH1:DTX [plasma membrane] (Homo sapiens)
DTX [cytosol] (Homo sapiens)
DTX1 [cytosol] (Homo sapiens)
Cleavage of CNTN1:NOTCH1 complex releases NICD1 (Homo sapiens)
CNTN1:NOTCH1:DTX [plasma membrane] (Homo sapiens)
NOTCH1:DTX [plasma membrane] (Homo sapiens)
DTX [cytosol] (Homo sapiens)
DTX1 [cytosol] (Homo sapiens)
NICD1:DTX [cytosol] (Homo sapiens)
DTX [cytosol] (Homo sapiens)
DTX1 [cytosol] (Homo sapiens)
Cleavage of DNER:NOTCH1 complex releases NICD1 (Homo sapiens)
DNER:NOTCH1:DTX [plasma membrane] (Homo sapiens)
NOTCH1:DTX [plasma membrane] (Homo sapiens)
DTX [cytosol] (Homo sapiens)
DTX1 [cytosol] (Homo sapiens)
NICD1:DTX [cytosol] (Homo sapiens)
DTX [cytosol] (Homo sapiens)
DTX1 [cytosol] (Homo sapiens)
Contactin-1 (CNTN1) binds NOTCH1 (Homo sapiens)
CNTN1:NOTCH1:DTX [plasma membrane] (Homo sapiens)
NOTCH1:DTX [plasma membrane] (Homo sapiens)
DTX [cytosol] (Homo sapiens)
DTX1 [cytosol] (Homo sapiens)
NOTCH1:DTX [plasma membrane] (Homo sapiens)
DTX [cytosol] (Homo sapiens)
DTX1 [cytosol] (Homo sapiens)
DTX binds NOTCH1 (Homo sapiens)
DTX [cytosol] (Homo sapiens)
DTX1 [cytosol] (Homo sapiens)
NOTCH1:DTX [plasma membrane] (Homo sapiens)
DTX [cytosol] (Homo sapiens)
DTX1 [cytosol] (Homo sapiens)
DTX recruits beta-arrestin (ARRB) to NOTCH (Homo sapiens)
NOTCH1:DTX [plasma membrane] (Homo sapiens)
DTX [cytosol] (Homo sapiens)
DTX1 [cytosol] (Homo sapiens)
NOTCH1:DTX:ARRB [plasma membrane] (Homo sapiens)
NOTCH1:DTX [plasma membrane] (Homo sapiens)
DTX [cytosol] (Homo sapiens)
DTX1 [cytosol] (Homo sapiens)
ITCH binds DTX (Homo sapiens)
DTX [cytosol] (Homo sapiens)
DTX1 [cytosol] (Homo sapiens)
DTX:ITCH [cytosol] (Homo sapiens)
DTX [cytosol] (Homo sapiens)
DTX1 [cytosol] (Homo sapiens)
ITCH ubiquitinates DTX (Homo sapiens)
DTX:ITCH [cytosol] (Homo sapiens)
DTX [cytosol] (Homo sapiens)
DTX1 [cytosol] (Homo sapiens)
Ub-DTX:ITCH [cytosol] (Homo sapiens)
DTX [cytosol] (Homo sapiens)
DTX1 [cytosol] (Homo sapiens)
NOTCH1 binds DNER (Homo sapiens)
DNER:NOTCH1:DTX [plasma membrane] (Homo sapiens)
NOTCH1:DTX [plasma membrane] (Homo sapiens)
DTX [cytosol] (Homo sapiens)
DTX1 [cytosol] (Homo sapiens)
NOTCH1:DTX [plasma membrane] (Homo sapiens)
DTX [cytosol] (Homo sapiens)
DTX1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q86Y01 DTX1
Gene Names
DTX1
Chain
chain:1-620
Reference Genes
BioGPS Gene:1840 DTX1
COSMIC (genes):DTX1 DTX1
CTD Gene:1840 DTX1
dbSNP Gene:1840 DTX1
ENSEMBL:ENSG00000135144 DTX1
HGNC:3060 DTX1
KEGG:hsa:1840 DTX1
Monarch:1840 DTX1
NCBI Gene:1840 DTX1
OMIM:602582 DTX1
UCSC:Q86Y01 DTX1
Reference Transcript
RefSeq:NM_004416.2 DTX1
RefSeq:XM_011538009.2 DTX1
Other Identifiers
11724930_a_at
16757391
1840
227336_PM_at
227336_at
3432557
3432558
3432559
3432560
3432561
3432571
3432572
3432573
3432574
3432575
3432576
3432579
3432580
3432581
3432583
3432584
3432585
3432586
3432587
3432588
3432589
3432595
57025_at
7958931
A_14_P113035
A_23_P36567
A_24_P290751
GE61619
GO:0002376
GO:0003713
GO:0003824
GO:0005112
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006351
GO:0006355
GO:0006366
GO:0007166
GO:0007219
GO:0008270
GO:0008593
GO:0010001
GO:0016567
GO:0016604
GO:0016740
GO:0017124
GO:0030154
GO:0030217
GO:0031625
GO:0043226
GO:0045581
GO:0045665
GO:0045893
GO:0046872
GO:0060090
GO:0061630
GO:0140096
GO:0140110
GO:1990830
HMNXSV003055162
Hs.124024.0.S2_3p_at
Hs.124024.0.S2_3p_x_at
ILMN_1689002
PH_hs_0029144
TC12000887.hg
Participates
as a component of
rNotch1:DTX1 [plasma membrane] (Rattus norvegicus)
as a member of
DTX [cytosol] (Homo sapiens)
Inferred To
Dtx1 [cytosol]
(Mus musculus)
Dtx1 [cytosol]
(Rattus norvegicus)
DTX1 [cytosol]
(Bos taurus)
DTX1 [cytosol]
(Canis familiaris)
DTX1 [cytosol]
(Gallus gallus)
DTX1 [cytosol]
(Sus scrofa)
dx [cytosol]
(Drosophila melanogaster)
dtx1 [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
NP_004407.2
,
XP_011536311.1
ENSEMBL
ENSP00000257600
,
ENST00000548759
,
ENST00000257600
,
ENSP00000510707
OpenTargets
ENSG00000135144
IntEnz
2.3.2.27
HPA
ENSG00000135144-DTX1
PRO
Q86Y01
Pharos - Targets
Q86Y01
PDB
6Y5P
,
6Y5N
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q96J02 ITCH
2
Ub-C871-ITCH [cytosol]
(R-HSA-8864515)
ITCH [cytosol]
(R-HSA-975995)
0.463
2
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