Autocatalytic activation of bound proMMP2

Stable Identifier
R-HSA-1604368
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Cleavage of the Asn66-Leu67 bond of MMP2 activates it sufficiently to allow autocleavage of the Asn109-Tyr110 bond (Okada et al. 1990, Strongin et al. 1993, Crabbe et al. 1994a, Atkinson et al. 1995, Sang et al. 1996). Residue numbering here refers to the UniProt canonical sequence.

Literature References
PubMed ID Title Journal Year
8314771 Plasma membrane-dependent activation of the 72-kDa type IV collagenase is prevented by complex formation with TIMP-2

Strongin, AY, Marmer, BL, Grant, GA, Goldberg, GI

J Biol Chem 1993
2269296 Matrix metalloproteinase 2 from human rheumatoid synovial fibroblasts. Purification and activation of the precursor and enzymic properties

Okada, Y, Morodomi, T, Enghild, JJ, Suzuki, K, Yasui, A, Nakanishi, I, Salvesen, G, Nagase, H

Eur J Biochem 1990
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
serine-type endopeptidase activity of MMP14:TIMP2:MMP2 intermediate form [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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