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PRSS1(24-247) [extracellular region]
Stable Identifier
R-HSA-1602489
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
PRSS1, Trypsin-1, TRY1_HUMAN
Locations in the PathwayBrowser
Expand all
Extracellular matrix organization (Homo sapiens)
Degradation of the extracellular matrix (Homo sapiens)
Activation of Matrix Metalloproteinases (Homo sapiens)
Activation of proMMP10 (Homo sapiens)
proMMP10 activators [extracellular region] (Homo sapiens)
PRSS1(24-247) [extracellular region] (Homo sapiens)
Activation of proMMP8 (Homo sapiens)
proMMP8 initial activators [extracellular region] (Homo sapiens)
PRSS1(24-247) [extracellular region] (Homo sapiens)
Trypsin, plasmin [extracellular region] (Homo sapiens)
PRSS1(24-247) [extracellular region] (Homo sapiens)
Activation of proMMP9 by proteases (Homo sapiens)
proMMP9 activating proteases [extracellular region] (Homo sapiens)
PRSS1(24-247) [extracellular region] (Homo sapiens)
Initial activation of proMMP1 (Homo sapiens)
proMMP1 initial activators [extracellular region] (Homo sapiens)
PRSS1(24-247) [extracellular region] (Homo sapiens)
Initial activation of proMMP13 by plasmin and trypsin (Homo sapiens)
Trypsin, plasmin [extracellular region] (Homo sapiens)
PRSS1(24-247) [extracellular region] (Homo sapiens)
Initial activation of proMMP3 (Homo sapiens)
proMMP3 initial activators [extracellular region] (Homo sapiens)
PRSS1(24-247) [extracellular region] (Homo sapiens)
Initial activation of proMMP7 by trypsin (Homo sapiens)
MMP7 initial activators [extracellular region] (Homo sapiens)
PRSS1(24-247) [extracellular region] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of vitamins and cofactors (Homo sapiens)
Metabolism of water-soluble vitamins and cofactors (Homo sapiens)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Homo sapiens)
Uptake of dietary cobalamins into enterocytes (Homo sapiens)
Pancreatic proteases degrade TCN1:RCbl (Homo sapiens)
PRSS1,3,CTRB1,2 [extracellular region] (Homo sapiens)
PRSS1(24-247) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P07477 PRSS1
Gene Names
PRSS1, TRP1, TRY1, TRYP1
Chain
signal peptide:1-15, propeptide:16-23, chain:24-247, chain:24-122, chain:123-247
Reference Genes
BioGPS Gene:5644 PRSS1
COSMIC (genes):PRSS1 PRSS1
CTD Gene:5644 PRSS1
dbSNP Gene:5644 PRSS1
ENSEMBL:ENSG00000204983 PRSS1
HGNC:9475 PRSS1
KEGG:hsa:5644 PRSS1
Monarch:5644 PRSS1
NCBI Gene:5644 PRSS1
OMIM:276000 PRSS1
UCSC:P07477 PRSS1
Reference Transcript
RefSeq:NM_002769.4 PRSS1
Other Identifiers
11716820_x_at
11760149_a_at
11760150_x_at
17052652
205869_PM_at
205869_at
3028758
3028759
3028762
3028764
3028767
3028768
3028769
3028771
3028772
3028773
3028774
3028775
3028776
3028777
3028778
3028779
3028780
3028781
3028782
3028784
3028786
3028789
3028792
3028795
3028799
3028807
3028819
3167210
3167212
3167215
3203657
32796_f_at
5644
8136795
A_23_P380754
GO:0003824
GO:0004252
GO:0005576
GO:0005615
GO:0006508
GO:0007586
GO:0008236
GO:0016787
GO:0022617
GO:0030198
GO:0030312
GO:0031012
GO:0046872
GO:0062023
GO:0072562
GO:0140096
HMNXSV003013589
ILMN_1734773
M22612_f_at
PH_hs_0040453
TC07003345.hg
g4506144_3p_x_at
Participates
as a member of
PRSS1,3,CTRB1,2 [extracellular region] (Homo sapiens)
MMP7 initial activators [extracellular region] (Homo sapiens)
proMMP3 initial activators [extracellular region] (Homo sapiens)
proMMP1 initial activators [extracellular region] (Homo sapiens)
proMMP10 activators [extracellular region] (Homo sapiens)
Trypsin, plasmin [extracellular region] (Homo sapiens)
proMMP8 initial activators [extracellular region] (Homo sapiens)
as a candidate of
proMMP9 activating proteases [extracellular region] (Homo sapiens)
Other forms of this molecule
pro-PRSS1 [zymogen granule]
Inferred To
Try5 [extracellular region]
(Mus musculus)
Try5 [extracellular region]
(Rattus norvegicus)
tpsb2 [extracellular region]
(Xenopus tropicalis)
LOC121107389 [extracellular region]
(Gallus gallus)
PRSS2 [extracellular region]
(Bos taurus)
PRSS2 [extracellular region]
(Canis familiaris)
Homologues of PRSS1(24-247) [extracellular region]
(Mus musculus)
Homologues of PRSS1(24-247) [extracellular region]
(Rattus norvegicus)
prss59.2 [extracellular region]
(Danio rerio)
PRSS2(24-247) [extracellular region]
(Mus musculus)
Prss1l [extracellular region]
(Mus musculus)
LOC107054567 [extracellular region]
(Gallus gallus)
try [extracellular region]
(Sus scrofa)
LOC101732100 [extracellular region]
(Xenopus tropicalis)
si:dkey-33m11.8 [extracellular region]
(Danio rerio)
LOC102554637 [extracellular region]
(Rattus norvegicus)
Prss3 [extracellular region]
(Mus musculus)
Prss3 [extracellular region]
(Rattus norvegicus)
LOC105945797 [extracellular region]
(Xenopus tropicalis)
prss1 [extracellular region]
(Danio rerio)
Prss1 [extracellular region]
(Mus musculus)
Prss3l [extracellular region]
(Mus musculus)
prss59.1 [extracellular region]
(Danio rerio)
LOC101730988 [extracellular region]
(Xenopus tropicalis)
LOC100485189 [extracellular region]
(Xenopus tropicalis)
Prss2l1 [extracellular region]
(Rattus norvegicus)
Homologues of PRSS2(24-247) [extracellular region]
(Danio rerio)
Homologues of PRSS2(24-247) [extracellular region]
(Gallus gallus)
Homologues of PRSS2(24-247) [extracellular region]
(Xenopus tropicalis)
LOC116412104 [extracellular region]
(Xenopus tropicalis)
Try10 [extracellular region]
(Mus musculus)
Try10 [extracellular region]
(Rattus norvegicus)
try10 [extracellular region]
(Xenopus tropicalis)
wu:fd14c02 [extracellular region]
(Danio rerio)
PRSS1(24-247) [extracellular region]
(Mus musculus)
PRSS1(24-247) [extracellular region]
(Rattus norvegicus)
Cross References
RefSeq
NP_002760.1
ZINC - World Drugs
TRY1_HUMAN
Guide to Pharmacology - Targets
2397
ENSEMBL
ENST00000616256
,
ENSP00000479217
,
ENSP00000308720
OpenTargets
ENSG00000204983
ZINC - FDA approved
TRY1_HUMAN
ZINC - Substances
TRY1_HUMAN
ZINC - Biogenic
TRY1_HUMAN
ZINC target
P07477
PRO
P07477
GlyGen
P07477
PDB
8H3S
,
1TRN
,
2RA3
,
4WXV
,
1FXY
,
7QE9
,
7QE8
,
4WWY
ZINC - Investigational
TRY1_HUMAN
HPA
ENSG00000204983-PRSS1
Pharos - Targets
P07477
Orphanet
PRSS1
ZINC - Predictions - Purchasable
TRY1_HUMAN
HMDB Protein
HMDBP08086
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