Reactome | PRSS1(24-247) [extracellular region]

PRSS1(24-247) [extracellular region]

Stable Identifier

R-HSA-1602489

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

PRSS1, Trypsin-1, TRY1_HUMAN

Locations in the PathwayBrowser

Expand all

Metabolism (Homo sapiens)

- Metabolism of vitamins and cofactors (Homo sapiens)
  - Metabolism of water-soluble vitamins and cofactors (Homo sapiens)
    - Cobalamin (Cbl, vitamin B12) transport and metabolism (Homo sapiens)
      - Uptake of dietary cobalamins into enterocytes (Homo sapiens)
        
        Pancreatic proteases degrade TCN1:RCbl (Homo sapiens)
        
        PRSS1,3,CTRB1,2 [extracellular region] (Homo sapiens)
        
        PRSS1(24-247) [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P07477 PRSS1

Gene Names

PRSS1, TRP1, TRY1, TRYP1

Chain

signal peptide:1-15, propeptide:16-23, chain:24-247, chain:24-122, chain:123-247

Reference Genes

BioGPS Gene:5644 PRSS1

COSMIC (genes):PRSS1 PRSS1

CTD Gene:5644 PRSS1

dbSNP Gene:5644 PRSS1

ENSEMBL:ENSG00000204983 PRSS1

ENSEMBL:ENSG00000204983.15 PRSS1

ENSEMBL:ENSG00000274247.4 PRSS1

HGNC:9475 PRSS1

KEGG Gene (Homo sapiens):5644 PRSS1

Monarch:5644 PRSS1

NCBI Gene:5644 PRSS1

OMIM:276000 PRSS1

UCSC:P07477 PRSS1

Reference Transcript

RefSeq:NM_002769.4 PRSS1

Other Identifiers

0000630524

11716820_x_at

205869_PM_at

205869_at

3028762

3028764

3028769

3028771

3028776

3028777

3028779

3028780

3028782

3028784

3028789

3028792

3028795

3028799

3028807

3167215

32796_f_at

5644

8136795

A_23_P380754

GO:0004252

GO:0005576

GO:0005615

GO:0006508

GO:0007586

GO:0008233

GO:0008236

GO:0016787

GO:0022617

GO:0030198

GO:0030312

GO:0031012

GO:0046872

GO:0062023

GO:0072562

GO:0140096

HMNXSV003013589

ILMN_1734773

M22612_f_at

TC07003345.hg

Participates

as a candidate of

proMMP9 activating proteases [extracellular region] (Homo sapiens)

as a member of

Inferred To

Prss3 [extracellular region] (Rattus norvegicus)

Try4 [extracellular region] (Mus musculus)

LOC105945797 [extracellular region] (Xenopus tropicalis)

PRSS2 [extracellular region] (Bos taurus)

PRSS2 [extracellular region] (Gallus gallus)

Homologues of PRSS1(24-247) [extracellular region] (Rattus norvegicus)

PRSS2(24-247) [extracellular region] (Canis familiaris)

PRSS2(24-247) [extracellular region] (Danio rerio)

PRSS2(24-247) [extracellular region] (Rattus norvegicus)

PRSS2(24-247) [extracellular region] (Xenopus tropicalis)

prss2 [extracellular region] (Xenopus tropicalis)

scarb1 [extracellular region] (Xenopus tropicalis)

try [extracellular region] (Danio rerio)

try [extracellular region] (Sus scrofa)

LOC107054568 [extracellular region] (Gallus gallus)

LOC560023 [extracellular region] (Danio rerio)

Homologues of PRSS2(24-247) [extracellular region] (Danio rerio)

Homologues of PRSS2(24-247) [extracellular region] (Gallus gallus)

Homologues of PRSS2(24-247) [extracellular region] (Xenopus tropicalis)

LOC116412104 [extracellular region] (Xenopus tropicalis)

Cross References

RefSeq

NP_002760.1

ZINC - World Drugs

TRY1_HUMAN

Guide to Pharmacology - Targets

2397

OpenTargets

ENSG00000204983

ZINC - FDA approved

TRY1_HUMAN

ZINC - Substances

TRY1_HUMAN

ZINC - Biogenic

TRY1_HUMAN

ZINC target

P07477

PRO

P07477

PDB

7QE8, 4WXV, 4WWY, 7QE9, 2RA3, 1FXY, 1TRN

ZINC - Investigational

TRY1_HUMAN

GeneCards

P07477

HPA

ENSG00000204983-PRSS1

Ensembl

ENST00000311737, ENST00000616256, ENSG00000204983, ENSG00000274247, ENSP00000308720, ENSP00000479217

Pharos - Targets

P07477

ZINC - Predictions - Purchasable

TRY1_HUMAN

Orphanet

15155

HMDB Protein

HMDBP08086

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