Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
PRSS1(24-247) [extracellular region]
Stable Identifier
R-HSA-1602489
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
PRSS1, Trypsin-1, TRY1_HUMAN
Locations in the PathwayBrowser
Expand all
Extracellular matrix organization (Homo sapiens)
Degradation of the extracellular matrix (Homo sapiens)
Activation of Matrix Metalloproteinases (Homo sapiens)
Activation of proMMP10 (Homo sapiens)
proMMP10 activators [extracellular region] (Homo sapiens)
PRSS1(24-247) [extracellular region] (Homo sapiens)
Activation of proMMP8 (Homo sapiens)
proMMP8 initial activators [extracellular region] (Homo sapiens)
PRSS1(24-247) [extracellular region] (Homo sapiens)
Trypsin, plasmin [extracellular region] (Homo sapiens)
PRSS1(24-247) [extracellular region] (Homo sapiens)
Activation of proMMP9 by proteases (Homo sapiens)
proMMP9 activating proteases [extracellular region] (Homo sapiens)
PRSS1(24-247) [extracellular region] (Homo sapiens)
Initial activation of proMMP1 (Homo sapiens)
proMMP1 initial activators [extracellular region] (Homo sapiens)
PRSS1(24-247) [extracellular region] (Homo sapiens)
Initial activation of proMMP13 by plasmin and trypsin (Homo sapiens)
Trypsin, plasmin [extracellular region] (Homo sapiens)
PRSS1(24-247) [extracellular region] (Homo sapiens)
Initial activation of proMMP3 (Homo sapiens)
proMMP3 initial activators [extracellular region] (Homo sapiens)
PRSS1(24-247) [extracellular region] (Homo sapiens)
Initial activation of proMMP7 by trypsin (Homo sapiens)
MMP7 initial activators [extracellular region] (Homo sapiens)
PRSS1(24-247) [extracellular region] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of vitamins and cofactors (Homo sapiens)
Metabolism of water-soluble vitamins and cofactors (Homo sapiens)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Homo sapiens)
Uptake of dietary cobalamins into enterocytes (Homo sapiens)
Pancreatic proteases degrade TCN1:RCbl (Homo sapiens)
PRSS1,3,CTRB1,2 [extracellular region] (Homo sapiens)
PRSS1(24-247) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P07477 PRSS1
Gene Names
PRSS1, TRP1, TRY1, TRYP1
Chain
signal peptide:1-15, propeptide:16-23, chain:24-247, chain:24-122, chain:123-247
Reference Genes
BioGPS Gene:5644 PRSS1
COSMIC (genes):PRSS1 PRSS1
CTD Gene:5644 PRSS1
dbSNP Gene:5644 PRSS1
ENSEMBL:ENSG00000204983 PRSS1
ENSEMBL:ENSG00000204983.15 PRSS1
ENSEMBL:ENSG00000274247.4 PRSS1
HGNC:9475 PRSS1
KEGG Gene (Homo sapiens):5644 PRSS1
Monarch:5644 PRSS1
NCBI Gene:5644 PRSS1
OMIM:276000 PRSS1
UCSC:P07477 PRSS1
Reference Transcript
RefSeq:NM_002769.4 PRSS1
Other Identifiers
0000630524
11716820_x_at
205869_PM_at
205869_at
3028762
3028764
3028769
3028771
3028776
3028777
3028779
3028780
3028782
3028784
3028789
3028792
3028795
3028799
3028807
3167215
32796_f_at
5644
8136795
A_23_P380754
GO:0004252
GO:0005576
GO:0005615
GO:0006508
GO:0007586
GO:0008233
GO:0008236
GO:0016787
GO:0022617
GO:0030198
GO:0030312
GO:0031012
GO:0046872
GO:0062023
GO:0072562
GO:0140096
HMNXSV003013589
ILMN_1734773
M22612_f_at
TC07003345.hg
Participates
as a candidate of
proMMP9 activating proteases [extracellular region] (Homo sapiens)
as a member of
proMMP3 initial activators [extracellular region] (Homo sapiens)
proMMP8 initial activators [extracellular region] (Homo sapiens)
Trypsin, plasmin [extracellular region] (Homo sapiens)
proMMP1 initial activators [extracellular region] (Homo sapiens)
MMP7 initial activators [extracellular region] (Homo sapiens)
proMMP10 activators [extracellular region] (Homo sapiens)
PRSS1,3,CTRB1,2 [extracellular region] (Homo sapiens)
Inferred To
Prss3 [extracellular region]
(Rattus norvegicus)
Try4 [extracellular region]
(Mus musculus)
LOC105945797 [extracellular region]
(Xenopus tropicalis)
PRSS2 [extracellular region]
(Bos taurus)
PRSS2 [extracellular region]
(Gallus gallus)
Homologues of PRSS1(24-247) [extracellular region]
(Rattus norvegicus)
PRSS2(24-247) [extracellular region]
(Canis familiaris)
PRSS2(24-247) [extracellular region]
(Danio rerio)
PRSS2(24-247) [extracellular region]
(Rattus norvegicus)
PRSS2(24-247) [extracellular region]
(Xenopus tropicalis)
prss2 [extracellular region]
(Xenopus tropicalis)
scarb1 [extracellular region]
(Xenopus tropicalis)
try [extracellular region]
(Danio rerio)
try [extracellular region]
(Sus scrofa)
LOC107054568 [extracellular region]
(Gallus gallus)
LOC560023 [extracellular region]
(Danio rerio)
Homologues of PRSS2(24-247) [extracellular region]
(Danio rerio)
Homologues of PRSS2(24-247) [extracellular region]
(Gallus gallus)
Homologues of PRSS2(24-247) [extracellular region]
(Xenopus tropicalis)
LOC116412104 [extracellular region]
(Xenopus tropicalis)
Cross References
RefSeq
NP_002760.1
ZINC - World Drugs
TRY1_HUMAN
Guide to Pharmacology - Targets
2397
OpenTargets
ENSG00000204983
ZINC - FDA approved
TRY1_HUMAN
ZINC - Substances
TRY1_HUMAN
ZINC - Biogenic
TRY1_HUMAN
ZINC target
P07477
PRO
P07477
PDB
7QE8
,
4WXV
,
4WWY
,
7QE9
,
2RA3
,
1FXY
,
1TRN
ZINC - Investigational
TRY1_HUMAN
GeneCards
P07477
HPA
ENSG00000204983-PRSS1
Ensembl
ENST00000311737
,
ENST00000616256
,
ENSG00000204983
,
ENSG00000274247
,
ENSP00000308720
,
ENSP00000479217
Pharos - Targets
P07477
ZINC - Predictions - Purchasable
TRY1_HUMAN
Orphanet
15155
HMDB Protein
HMDBP08086
© 2023
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text