Initial activation of proMMP13 by plasmin and trypsin

Stable Identifier
R-HSA-1602488
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region
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Initial activation of proMMP13 by plasmin and trypsin
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proMMP13 can be activated by plasmin and trypsin initially cleaving at Lys57-Glu58 followed by autoproteolysis at Glu103-Tyr104 (Knauper et al. 1996a).

Literature References
PubMed ID Title Journal Year
8663255 Cellular mechanisms for human procollagenase-3 (MMP-13) activation. Evidence that MT1-MMP (MMP-14) and gelatinase a (MMP-2) are able to generate active enzyme

Knäuper, V, Will, H, López-Otin, C, Smith, B, Atkinson, SJ, Stanton, H, Hembry, RM, Murphy, G

J Biol Chem 1996
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
serine-type endopeptidase activity of Trypsin, plasmin [extracellular region]
Physical Entity
Trypsin, plasmin [extracellular region]
Activity
serine-type endopeptidase activity (0004252)
Orthologous Events
Initial activation of proMMP13 by plasmin and trypsin (Canis familiaris)
Initial activation of proMMP13 by plasmin and trypsin (Danio rerio)
Initial activation of proMMP13 by plasmin and trypsin (Gallus gallus)
Initial activation of proMMP13 by plasmin and trypsin (Mus musculus)
Initial activation of proMMP13 by plasmin and trypsin (Rattus norvegicus)
Initial activation of proMMP13 by plasmin and trypsin (Sus scrofa)
Initial activation of proMMP13 by plasmin and trypsin (Xenopus tropicalis)
Authored
Jupe, S  (2011-09-09)
Reviewed
Butler, GS  (2012-02-28)
Overall, CM  (2012-02-28)
Created
Jupe, S  (2011-09-14)