Initial activation of proMMP13 by plasmin and trypsin

Stable Identifier
R-HSA-1602488
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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proMMP13 can be activated by plasmin and trypsin initially cleaving at Lys57-Glu58 followed by autoproteolysis at Glu103-Tyr104 (Knauper et al. 1996a).

Literature References
PubMed ID Title Journal Year
8663255 Cellular mechanisms for human procollagenase-3 (MMP-13) activation. Evidence that MT1-MMP (MMP-14) and gelatinase a (MMP-2) are able to generate active enzyme

Atkinson, SJ, Smith, B, López-Otin, C, Hembry, RM, Knäuper, V, Murphy, G, Will, H, Stanton, H

J Biol Chem 1996
Participants
Participates
Catalyst Activity

serine-type endopeptidase activity of Trypsin, plasmin [extracellular region]

Orthologous Events
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