Activation of proMMP11 by FURIN

Stable Identifier
R-HSA-1602484
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

proMMP11 has a furin recognition sequence and is activated by furin in the Golgi (Pei & Weiss 1996, Santavicca et al. 1996).

Literature References
PubMed ID Title Journal Year
7746327 Furin-dependent intracellular activation of the human stromelysin-3 zymogen

Pei, D, Weiss, SJ

Nature 1995
8645182 Characterization of structural determinants and molecular mechanisms involved in pro-stromelysin-3 activation by 4-aminophenylmercuric acetate and furin-type convertases

Santavicca, M, Noel, A, Angliker, H, Stoll, I, Segain, JP, Anglard, P, Chretien, M, Seidah, N, Basset, P

Biochem J 1996
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
serine-type endopeptidase activity of FURIN [Golgi membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
Cite Us!