Activation of proMMP11 by FURIN

Stable Identifier
R-HSA-1602484
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Golgi lumen
ReviewStatus
5/5
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Activation of proMMP11 by FURIN
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
proMMP11 has a furin recognition sequence and is activated by furin in the Golgi (Pei & Weiss 1996, Santavicca et al. 1996).
Literature References
PubMed ID Title Journal Year
8645182 Characterization of structural determinants and molecular mechanisms involved in pro-stromelysin-3 activation by 4-aminophenylmercuric acetate and furin-type convertases

Santavicca, M, Noel, A, Angliker, H, Stoll, I, Segain, JP, Anglard, P, Chretien, M, Seidah, N, Basset, P

Biochem J 1996
7746327 Furin-dependent intracellular activation of the human stromelysin-3 zymogen

Pei, D, Weiss, SJ

Nature 1995
Participants
Input
Output
Participates
as an event of
Catalyst Activity

serine-type endopeptidase activity of FURIN [Golgi membrane]

Physical Entity
FURIN [Golgi membrane] (Homo sapiens)
Activity
serine-type endopeptidase activity (GO:0004252)
Orthologous Events
Activation of proMMP11 by FURIN (Bos taurus)
Activation of proMMP11 by FURIN (Caenorhabditis elegans)
Activation of proMMP11 by FURIN (Canis familiaris)
Activation of proMMP11 by FURIN (Danio rerio)
Activation of proMMP11 by FURIN (Drosophila melanogaster)
Activation of proMMP11 by FURIN (Gallus gallus)
Activation of proMMP11 by FURIN (Mus musculus)
Activation of proMMP11 by FURIN (Rattus norvegicus)
Activation of proMMP11 by FURIN (Sus scrofa)
Activation of proMMP11 by FURIN (Xenopus tropicalis)
Authored
Jupe, S  (2011-09-09)
Reviewed
Butler, GS  (2012-02-28)
Overall, CM  (2012-02-28)
Created
Jupe, S  (2011-09-14)
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