Autocatalytic activation of MMP1

Stable Identifier
R-HSA-1602473
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
5/5
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Autocatalytic activation of MMP1
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Following initiating proteolytic cleavage by serine proteases the Cys92-Zn2+ bond is destabilized allowing autocleavage at Thr83-Leu84, generating a 42 kDa active form of MMP1 with about 20% of the activity of the 41 kDa form (Suzuki et al. 1990). Full activation is brought about by a further cleavage at Gln99-Phe100.

Literature References
PubMed ID Title Journal Year
2176865 Mechanisms of activation of tissue procollagenase by matrix metalloproteinase 3 (stromelysin)

Morodomi, T, Salvesen, G, Nagase, H, Suzuki, K, Enghild, JJ

Biochemistry 1990
Participants
Input
Output
Participates
as an event of
Catalyst Activity

serine-type endopeptidase activity of MMP1(54-469) [extracellular region]

Physical Entity
MMP1(54-469) [extracellular region] (Homo sapiens)
Activity
serine-type endopeptidase activity (GO:0004252)
Orthologous Events
Autocatalytic activation of MMP1 (Bos taurus)
Autocatalytic activation of MMP1 (Caenorhabditis elegans)
Autocatalytic activation of MMP1 (Canis familiaris)
Autocatalytic activation of MMP1 (Drosophila melanogaster)
Autocatalytic activation of MMP1 (Gallus gallus)
Autocatalytic activation of MMP1 (Mus musculus)
Autocatalytic activation of MMP1 (Rattus norvegicus)
Autocatalytic activation of MMP1 (Sus scrofa)
Autocatalytic activation of MMP1 (Xenopus tropicalis)
Authored
Jupe, S  (2011-09-09)
Reviewed
Butler, GS  (2012-02-28)
Overall, CM  (2012-02-28)
Created
Jupe, S  (2011-09-14)
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