Autocatalytic activation of MMP1

Stable Identifier
R-HSA-1602473
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Following initiating proteolytic cleavage by serine proteases the Cys92-Zn2+ bond is destabilized allowing autocleavage at Thr83-Leu84, generating a 42 kDa active form of MMP1 with about 20% of the activity of the 41 kDa form (Suzuki et al. 1990). Full activation is brought about by a further cleavage at Gln99-Phe100.

Literature References
PubMed ID Title Journal Year
2176865 Mechanisms of activation of tissue procollagenase by matrix metalloproteinase 3 (stromelysin)

Suzuki, K, Enghild, JJ, Morodomi, T, Salvesen, G, Nagase, H

Biochemistry 1990
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
serine-type endopeptidase activity of MMP1(54-469) [extracellular region]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created