Activation of proMMP10

Stable Identifier
R-HSA-1602458
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
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proMMP10 is similar in sequence to proMMP3 with just one residue difference in the bait region. The activation mechanism is believed to be similar, namely cleavage in the N-terminal bait region, followed by autocatalytic cleavage at His81-Phe82 (Woessner & Nagasse 2000). proMMP10 is activated by plasmin, trypsin and chymotrypsin.

Literature References
PubMed ID Title Journal Year
  Matrix Metalloproteinases and TIMPs

Woessner, J, Nagase, H

  2000
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
serine-type endopeptidase activity of proMMP10 activators [extracellular region]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created