Activation of proMMP10

Stable Identifier
R-HSA-1602458
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
5/5
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Activation of proMMP10
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proMMP10 is similar in sequence to proMMP3 with just one residue difference in the bait region. The activation mechanism is believed to be similar, namely cleavage in the N-terminal bait region, followed by autocatalytic cleavage at His81-Phe82 (Woessner & Nagasse 2000). proMMP10 is activated by plasmin, trypsin and chymotrypsin.
Literature References
PubMed ID Title Journal Year
  Matrix Metalloproteinases and TIMPs

Woessner, J, Nagase, H

  2000
Participants
Input
Output
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as an event of
Catalyst Activity

serine-type endopeptidase activity of proMMP10 activators [extracellular region]

Physical Entity
proMMP10 activators [extracellular region] (Homo sapiens)
Activity
serine-type endopeptidase activity (GO:0004252)
Orthologous Events
Activation of proMMP10 (Bos taurus)
Activation of proMMP10 (Caenorhabditis elegans)
Activation of proMMP10 (Canis familiaris)
Activation of proMMP10 (Danio rerio)
Activation of proMMP10 (Gallus gallus)
Activation of proMMP10 (Mus musculus)
Activation of proMMP10 (Rattus norvegicus)
Activation of proMMP10 (Sus scrofa)
Activation of proMMP10 (Xenopus tropicalis)
Authored
Jupe, S  (2011-09-09)
Reviewed
Butler, GS  (2012-02-28)
Overall, CM  (2012-02-28)
Created
Jupe, S  (2011-09-14)
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