Reactome | PI is hydrolyzed to 1-acyl LPI by PLA2[15]

PI is hydrolyzed to 1-acyl LPI by PLA2[15]

Stable Identifier

R-HSA-1602377

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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PI is hydrolyzed to 1-acyl LPI by PLA2[15]

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At the plasma membrane, phosphatidylinositol (PI) is hydrolyzed, removing one of its acyl groups, to 1-acyl lysophosphatidylinositol (LPI) by secretory phospholipase A2 proteins (Singer et al. 2002, Ishizaki et al. 1999). These include: Group IB (PLA2G1B) (Grataroli et al. 1982); Group IIA (PLA2G2A) (Seilhamer et al. 1989); Group IID (PLA2G2D) (Ishizaki et al. 1999); Group IIE (PLA2G2E) (Suzuki et al. 2000); Group IIF (PLA2G2F) (Valentin et al. 2000); Calcium-dependent Group V (PLA2G5) (Chen et al. 1994); Group X (PLA2G10) (Cupillard et al. 1997, Pan et al. 2002); and Group XIIA (PLA2G12A) (Gelb et al. 2000, Murakami et al. 2003).

Literature References

PubMed ID	Title	Journal	Year
11112443	Cloning and recombinant expression of human group IIF-secreted phospholipase A(2) Gelb, MH, Ghomashchi, F, Valentin, E, Singer, AG, Lambeau, G, Lazdunski, M	Biochem Biophys Res Commun	2000
12161451	Crystal structure of human group X secreted phospholipase A2. Electrostatically neutral interfacial surface targets zwitterionic membranes Bahnson, BJ, Gelb, MH, Yu, BZ, Jain, MK, Ghomashchi, F, Singer, AG, Lambeau, G, Pan, YH	J Biol Chem	2002
10455175	Cloning and characterization of novel mouse and human secretory phospholipase A(2)s Hanasaki, K, Yokota, Y, Arita, H, Fujii, N, Kawamoto, K, Ono, T, Higashino, K, Suzuki, N, Ishizaki, J	J Biol Chem	1999
9188469	Cloning, chromosomal mapping, and expression of a novel human secretory phospholipase A2 Cupillard, L, Matteï, MG, Koumanov, K, Lambeau, G, Lazdunski, M	J Biol Chem	1997
12359733	Interfacial kinetic and binding properties of the complete set of human and mouse groups I, II, V, X, and XII secreted phospholipases A2 Gelb, MH, Le Calvez, C, Ghomashchi, F, Rouault, M, Singer, AG, Sadilek, M, Bollinger, J, Bezzine, S, Lambeau, G, Lazdunski, M, Nguyen, E	J Biol Chem	2002
7060561	Studies on prophospholipase A2 and its enzyme from human pancreatic juice. Catalytic properties and sequence of the N-terminal region Figarella, C, van der Ouderaa, F, De Haas, GH, Dijkman, R, Dutilh, CE, Grataroli, R	Eur J Biochem	1982
10681567	Structures, enzymatic properties, and expression of novel human and mouse secretory phospholipase A(2)s Hanasaki, K, Yokota, Y, Fujii, N, Ikeda, M, Kawamoto, K, Ono, T, Higashino, K, Ishizaki, J, Suzuki, N	J Biol Chem	2000
12522102	Cellular arachidonate-releasing function of novel classes of secretory phospholipase A2s (groups III and XII) Kokubu, F, Shimbara, S, Gelb, MH, Matsukura, S, Adachi, M, Masuda, S, Kudo, I, Bezzine, S, Lambeau, G, Lazdunski, M, Murakami, M	J Biol Chem	2003
8300559	Cloning and recombinant expression of a novel human low molecular weight Ca(2+)-dependent phospholipase A2 Tischfield, JA, Seilhamer, JJ, Engle, SJ, Chen, J	J Biol Chem	1994
2925608	Cloning and recombinant expression of phospholipase A2 present in rheumatoid arthritic synovial fluid Kloss, J, Vadas, P, Miller, JA, Pruzanski, W, Plant, S, Seilhamer, JJ, Johnson, LK	J Biol Chem	1989
11830583	Identification of a soluble form phospholipase A2 receptor as a circulating endogenous inhibitor for secretory phospholipase A2 Ono, T, Hanasaki, K, Kamitani, S, Higashino Ki, K, Yokota, Y, Arita, H	J. Biol. Chem.	2002
11031251	Cloning and recombinant expression of a structurally novel human secreted phospholipase A2 Gelb, MH, Ghomashchi, F, Valentin, E, Lambeau, G, Lazdunski, M	J Biol Chem	2000