Reactome | FBXW7gamma R361Q [nucleoplasm]

FBXW7gamma R361Q [nucleoplasm]

Stable Identifier

R-HSA-1602332

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

FBXW7gamma Arg361Gln, FBXW7-4 R361Q, FBXW7 isoform 4 R361Q

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Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - Signaling by NOTCH1 in Cancer (Homo sapiens)
    - FBXW7 Mutants and NOTCH1 in Cancer (Homo sapiens)
      - Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling (Homo sapiens)
        
        FBXW7 WD mutants do not bind NICD1 (Homo sapiens)
        
        FBXW7 WD mutants:SKP1:CUL1:RBX1 [nucleoplasm] (Homo sapiens)
        
        FBXW7 WD mutants [nucleoplasm] (Homo sapiens)
        
        FBXW7 R479/361Q mutant [nucleoplasm] (Homo sapiens)
        
        FBXW7gamma R361Q [nucleoplasm] (Homo sapiens)

Literature References

PubMed ID	Title	Journal	Year
17646409	FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors Draetta, G, Rao, S, Sears, R, Strack, P, Tibbitts, D, Hardwick, J, Pieters, R, Look, AT, Welcker, M, Meijerink, JP, Winter, C, Grim, J, O'Neil, J, Clurman, BE	J Exp Med	2007

External Reference Information

External Reference

UniProt:Q969H0-4 FBXW7

Gene Names

FBXW7, FBW7, FBX30, SEL10

Participates

as a candidate of

FBXW7 R479/361Q mutant [nucleoplasm] (Homo sapiens)

Other forms of this molecule

FBXW7gamma R387C [nucleoplasm]

FBXW7gamma R347C [nucleoplasm]

FBXW7gamma R347H [nucleoplasm]

FBXW7gamma R387L [nucleoplasm]

FBXW7gamma [nucleoplasm]

Modified Residues

Name

L-arginine 361 replaced with L-glutamine

Coordinate

361

PsiMod

L-arginine removal [MOD:01632]

A protein modification that effectively removes or replaces an L-arginine.

L-glutamine residue [MOD:00016]

A protein modification that effectively converts a source amino acid residue to an L-glutamine.

Disease

Name	Identifier	Synonyms
cancer	DOID:162	malignant tumor, malignant neoplasm, primary cancer
T-cell acute lymphoblastic leukemia	DOID:5603

Cross References

COSMIC

COSV55890822, COSM33845

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13616 CUL1	3	CUL1 [cytosol] (R-HSA-174230) CUL1 [nucleoplasm] (R-HSA-187551) G76-NEDD8-K720-CUL1 [cytosol] (R-HSA-8952519)	0.888	10
UniProt:P46531 NOTCH1	20	NOTCH1 L1678P S2 cleavage fragment [extracellular region] (R-HSA-2730745) NOTCH1 I1680N S2 cleavage fragment [extracellular region] (R-HSA-2730744) NOTCH1 I1718T S2 cleavage fragment [extracellular region] (R-HSA-2730757) NOTCH1 A1701P S2 cleavage fragment [plasma membrane] (R-HSA-2730742) NOTCH1 V1676D S2 cleavage fragment [extracellular region] (R-HSA-2730755) NOTCH1 I1680N Transmembrane Fragment [plasma membrane] (R-HSA-2684869) NOTCH1 I1718T Transmembrane Fragment [plasma membrane] (R-HSA-2684881) NOTCH1 I1616T Extracellular Fragment [extracellular region] (R-HSA-2684866) NOTCH1 L1596H Extracellular Fragment [extracellular region] (R-HSA-2684853) NOTCH1 L1678P Transmembrane Fragment [plasma membrane] (R-HSA-1485591) NOTCH1 A1701P Transmembrane Fragment [plasma membrane] (R-HSA-1485585) NOTCH1 I1616N Extracellular Fragment [extracellular region] (R-HSA-2684862) NOTCH1 L1593P Extracellular Fragment [extracellular region] (R-HSA-1485584) NOTCH1 R1598P Extracellular Fragment [extracellular region] (R-HSA-1485592) NOTCH1 V1576E Extracellular Fragment [extracellular region] (R-HSA-2684852) NOTCH1 V1676D Transmembrane Fragment [plasma membrane] (R-HSA-2684874) NOTCH1 F1592S Extracellular Fragment [extracellular region] (R-HSA-2684847) NOTCH1 L1574Q Extracellular Fragment [extracellular region] (R-HSA-2691203) p-NICD1 Q2440* [nucleoplasm] (R-HSA-2902207) p-NICD1 Q2395* [nucleoplasm] (R-HSA-2902205)	0.876	11
UniProt:P01106 MYC	2	MYC [nucleoplasm] (R-HSA-188379) PolyUb-MYC [nucleoplasm] (R-HSA-6783169)	0.832	7
UniProt:P63208 SKP1	2	SKP1 [cytosol] (R-HSA-174150) SKP1 [nucleoplasm] (R-HSA-187538)	0.821	11
UniProt:P24864 CCNE1	3	CCNE1 [nucleoplasm] (R-HSA-68363) CCNE1 [cytosol] (R-HSA-157443) Unfolded CCNE1 [cytosol] (R-HSA-6813836)	0.581	3
UniProt:Q96BA8 CREB3L1	7	CREB3L1 [Golgi membrane] (R-HSA-8874155) CREB3L1(427-519) [Golgi membrane] (R-HSA-8874139) CREB3L1(1-426) [Golgi membrane] (R-HSA-8874153) CREB3L1 [endoplasmic reticulum membrane] (R-HSA-8874157) CREB3L1(1-375) [cytosol] (R-HSA-8874215) CREB3L1(376-426) [Golgi membrane] (R-HSA-8874213) CREB3L1(1-375) [nucleoplasm] (R-HSA-8874222)	0.527	2

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