FBXW7alpha R465H [nucleoplasm]

Stable Identifier
R-HSA-1602330
Type
Genes and Transcripts [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
FBXW7alpha Arg465His, FBXW7-1 R465H
Locations in the PathwayBrowser
Expand all
Literature References
PubMed ID Title Journal Year
17646409 FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors

O'Neil, J, Grim, J, Strack, P, Rao, S, Tibbitts, D, Winter, C, Hardwick, J, Welcker, M, Meijerink, JP, Pieters, R, Draetta, G, Sears, R, Clurman, BE, Look, AT

J Exp Med 2007
External Reference Information
External Reference
UniProt:Q969H0-1 FBXW7
Gene Names
FBXW7, FBW7, FBX30, SEL10
Other Identifiers
0004120671
0004120722
0004590050
0103190671
11725751_a_at
11725752_x_at
11748766_a_at
13793
16980693
218751_s_at
222729_at
229419_at
2789959
2789960
2789961
2789962
2789963
2789964
2789965
2789967
2789970
2789971
2789974
2789977
2789978
2789979
2789981
2789987
2789988
2789990
2789991
2789992
2789993
2789999
2790000
2790001
2790007
2790008
2790009
2790010
2790011
2790012
2790046
2790047
2790048
2790049
2790050
2790051
29987
2OVP
2OVQ
2OVR
48937_at
55294
5IBK
5V4B
61691_at
74386_at
8103206
A_23_P81153
A_24_P174613
AAG16640
AAH37320
AAI17245
AAI17247
AAI43945
AAK57547
AAK60269
AAL06290
AAL06291
AAL07271
AF383178
AF411971
AF411972
AK001933
AY008274
AY033553
AY049984
B7Z2C8
BAA91986
BC037320
BC117244
BC117246
BC143944
CAB013793
CAB029987
CAH18160
CCDS34078
CCDS3777
CCDS3778
CR749305
ENSG00000109670
ENSP00000281708
ENSP00000296555
ENSP00000377528
ENSP00000474725
ENSP00000474971
ENST00000263981.9
ENST00000281708
ENST00000281708.9
ENST00000296555
ENST00000296555.10
ENST00000393956
ENST00000603548
ENST00000603548.6
ENST00000603841
ENST00000603841.1
EntrezGene:55294
EntrezGene:FBXW7
FBXW7
FBXW7-201
FBXW7-202
FBXW7-203
FBXW7-204
FBXW7-206
G0Z2K0
g8922851_3p_a_at
GE55961
GO:0000209
GO:0001570
GO:0001944
GO:0002376
GO:0003674
GO:0005515
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005654
GO:0005730
GO:0005737
GO:0005739
GO:0005783
GO:0005794
GO:0005829
GO:0006464
GO:0006605
GO:0006629
GO:0006810
GO:0006914
GO:0006950
GO:0007005
GO:0007049
GO:0007059
GO:0007062
GO:0007165
GO:0007219
GO:0008150
GO:0008219
GO:0008283
GO:0009056
GO:0009058
GO:0010629
GO:0010868
GO:0010883
GO:0010992
GO:0015031
GO:0016032
GO:0016567
GO:0019005
GO:0019899
GO:0030154
GO:0030234
GO:0030324
GO:0030332
GO:0030674
GO:0031146
GO:0031398
GO:0031625
GO:0031648
GO:0032182
GO:0032880
GO:0032991
GO:0034641
GO:0040011
GO:0042592
GO:0042752
GO:0042802
GO:0043130
GO:0043161
GO:0043226
GO:0043687
GO:0044403
GO:0045741
GO:0045746
GO:0048471
GO:0048511
GO:0048646
GO:0048856
GO:0048870
GO:0050816
GO:0050821
GO:0051276
GO:0051443
GO:0055088
GO:0070374
GO:0090049
GO:0097027
GO:1901800
GO:1902806
GO:1903026
GO:1903146
GO:1903378
GO:1903955
GO:1990452
GO:2000060
GO:2000346
GO:2000639
GO:2001205
HGNC:16712
Hs.31945.0.S2_3p_at
Hs.96487.0.A1_3p_at
Hs.96487.0.A1_3p_x_at
ILMN_1655906
ILMN_1668634
ILMN_1695379
ILMN_1754279
ILMN_1770484
IPR001680
IPR001810
IPR015943
IPR017986
IPR019775
IPR020472
IPR036047
IPR036322
LRG_1141
MIM:606278
NM_001013415
NM_001349798
NM_018315
NM_033632
NP_001013433
NP_001336727
NP_060785
NP_361014
PF00400
PF12937
PH_hs_0023734
PH_hs_0035786
PR00320
S4R3N3
S4R3U4
SM00256
SM00320
TC04001647.hg
UPI0000035D51
UPI0000035D56
UPI000007007E
XM_011532084
XM_011532085
XM_011532086
XM_011532087
XM_011532088
XM_024454121
XM_024454122
XM_024454123
XM_024454124
XM_024454125
XM_024454126
XP_011530386
XP_011530387
XP_011530388
XP_011530389
XP_011530390
XP_024309889
XP_024309890
XP_024309891
XP_024309892
XP_024309893
XP_024309894
Participant Of
hasMember
Other forms of this molecule
FBXW7alpha R505C [nucleoplasm]
FBXW7alpha R465C [nucleoplasm]
FBXW7alpha R479Q [nucleoplasm]
FBXW7alpha R505L [nucleoplasm]
FBXW7alpha [nucleoplasm]
Modified Residues
Name
L-arginine 465 replaced with L-histidine
Coordinate
465
PsiMod
L-histidine residue [MOD:00018]
A protein modification that effectively converts a source amino acid residue to an L-histidine.
L-arginine removal [MOD:01632]
A protein modification that effectively removes or replaces an L-arginine.
Disease
Name Identifier Synonyms
T-cell leukemia 715
cancer 162 malignant tumor, malignant neoplasm, primary cancer
Cross References
RefSeq
COSMIC
OpenTargets
GeneCards
PRO
PDB
Interactors (5)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P46531 NOTCH1  60 0.837 10
 UniProt:P63208 SKP1  2 0.688 5
 UniProt:Q13616 CUL1  3 0.669 4
 UniProt:P01106 MYC  2 0.669 4
 UniProt:P24864 CCNE1  3 0.581 3