Reactome | FBXW7gamma [nucleoplasm]

FBXW7gamma [nucleoplasm]

Stable Identifier

R-HSA-1602297

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

FBXW7-4

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Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - Signaling by NOTCH1 in Cancer (Homo sapiens)
    - Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer (Homo sapiens)
      - Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants (Homo sapiens)
        
        p-NICD1 PEST domain mutants do not bind FBXW7 (Homo sapiens)
        
        FBXW7:SKP1:CUL1:RBX1 [nucleoplasm] (Homo sapiens)
        
        FBXW7alpha/gamma [nucleoplasm] (Homo sapiens)
        
        FBXW7gamma [nucleoplasm] (Homo sapiens)
    - Signaling by NOTCH1 PEST Domain Mutants in Cancer (Homo sapiens)
      - Constitutive Signaling by NOTCH1 PEST Domain Mutants (Homo sapiens)
        
        p-NICD1 PEST domain mutants do not bind FBXW7 (Homo sapiens)
        
        FBXW7:SKP1:CUL1:RBX1 [nucleoplasm] (Homo sapiens)
        
        FBXW7alpha/gamma [nucleoplasm] (Homo sapiens)
        
        FBXW7gamma [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q969H0-4 FBXW7

Gene Names

FBXW7, FBW7, FBX30, SEL10

Participates

as a candidate of

FBXW7alpha/gamma [nucleoplasm] (Homo sapiens)

Other forms of this molecule

FBXW7gamma R387L [nucleoplasm]

FBXW7gamma R347H [nucleoplasm]

FBXW7gamma R361Q [nucleoplasm]

FBXW7gamma R347C [nucleoplasm]

FBXW7gamma R387C [nucleoplasm]

Cross References

OpenTargets

ENSG00000109670

ENSEMBL

ENSG00000109670, ENSP00000281708, ENST00000296555, ENSP00000474971, ENST00000393956, ENST00000281708, ENSP00000474725, ENST00000603841, ENSP00000296555, ENSP00000377528, ENST00000603548

HPA

ENSG00000109670-FBXW7

GeneCards

FBXW7

PRO

Q969H0

Pharos - Targets

Q969H0

GlyGen

Q969H0

PDB

5IBK, 2OVR, 2OVQ, 7T1Z, 7T1Y, 5V4B, 2OVP

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13616 CUL1	3	CUL1 [cytosol] (R-HSA-174230) CUL1 [nucleoplasm] (R-HSA-187551) G76-NEDD8-K720-CUL1 [cytosol] (R-HSA-8952519)	0.888	10
UniProt:P46531 NOTCH1	20	NOTCH1 L1678P S2 cleavage fragment [extracellular region] (R-HSA-2730745) NOTCH1 I1680N S2 cleavage fragment [extracellular region] (R-HSA-2730744) NOTCH1 I1718T S2 cleavage fragment [extracellular region] (R-HSA-2730757) NOTCH1 A1701P S2 cleavage fragment [plasma membrane] (R-HSA-2730742) NOTCH1 V1676D S2 cleavage fragment [extracellular region] (R-HSA-2730755) NOTCH1 I1680N Transmembrane Fragment [plasma membrane] (R-HSA-2684869) NOTCH1 I1718T Transmembrane Fragment [plasma membrane] (R-HSA-2684881) NOTCH1 I1616T Extracellular Fragment [extracellular region] (R-HSA-2684866) NOTCH1 L1596H Extracellular Fragment [extracellular region] (R-HSA-2684853) NOTCH1 L1678P Transmembrane Fragment [plasma membrane] (R-HSA-1485591) NOTCH1 A1701P Transmembrane Fragment [plasma membrane] (R-HSA-1485585) NOTCH1 I1616N Extracellular Fragment [extracellular region] (R-HSA-2684862) NOTCH1 L1593P Extracellular Fragment [extracellular region] (R-HSA-1485584) NOTCH1 R1598P Extracellular Fragment [extracellular region] (R-HSA-1485592) NOTCH1 V1576E Extracellular Fragment [extracellular region] (R-HSA-2684852) NOTCH1 V1676D Transmembrane Fragment [plasma membrane] (R-HSA-2684874) NOTCH1 F1592S Extracellular Fragment [extracellular region] (R-HSA-2684847) NOTCH1 L1574Q Extracellular Fragment [extracellular region] (R-HSA-2691203) p-NICD1 Q2440* [nucleoplasm] (R-HSA-2902207) p-NICD1 Q2395* [nucleoplasm] (R-HSA-2902205)	0.876	11
UniProt:P01106 MYC	2	MYC [nucleoplasm] (R-HSA-188379) PolyUb-MYC [nucleoplasm] (R-HSA-6783169)	0.832	7
UniProt:P63208 SKP1	2	SKP1 [cytosol] (R-HSA-174150) SKP1 [nucleoplasm] (R-HSA-187538)	0.821	11
UniProt:P24864 CCNE1	3	CCNE1 [cytosol] (R-HSA-157443) CCNE1 [nucleoplasm] (R-HSA-68363) Unfolded CCNE1 [cytosol] (R-HSA-6813836)	0.581	3
UniProt:Q96BA8 CREB3L1	7	CREB3L1 [Golgi membrane] (R-HSA-8874155) CREB3L1(427-519) [Golgi membrane] (R-HSA-8874139) CREB3L1(1-426) [Golgi membrane] (R-HSA-8874153) CREB3L1 [endoplasmic reticulum membrane] (R-HSA-8874157) CREB3L1(1-375) [cytosol] (R-HSA-8874215) CREB3L1(376-426) [Golgi membrane] (R-HSA-8874213) CREB3L1(1-375) [nucleoplasm] (R-HSA-8874222)	0.527	2

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