Reactome | PROS1(25-41) [Golgi lumen]

PROS1(25-41) [Golgi lumen]

Stable Identifier

R-HSA-159792

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

Golgi lumen

Synonyms

protein S propeptide

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation (Homo sapiens)
    - Gamma-carboxylation, transport, and amino-terminal cleavage of proteins (Homo sapiens)
      - Removal of aminoterminal propeptides from gamma-carboxylated proteins (Homo sapiens)
        
        Furin cleaves pro-protein S to protein S (Homo sapiens)
        
        PROS1(25-41) [Golgi lumen] (Homo sapiens)

Literature References

PubMed ID	Title	Journal	Year
420821	Characterization of protein S, a gamma-carboxyglutamic acid containing protein from bovine and human plasma DiScipio, RG, Davie, EW	Biochemistry	1979

External Reference Information

External Reference

UniProt:P07225 PROS1

Gene Names

PROS1, PROS

Chain

signal peptide:1-24, propeptide:25-41, chain:42-676

Reference Genes

BioGPS Gene:5627 PROS1

COSMIC (genes):PROS1 PROS1

CTD Gene:5627 PROS1

dbSNP Gene:5627 PROS1

ENSEMBL:ENSG00000184500 PROS1

ENSEMBL_homo_sapiens_GENE:ENSG00000184500.16 PROS1

HGNC:9456 PROS1

KEGG Gene (Homo sapiens):5627 PROS1

Monarch:5627 PROS1

NCBI Gene:5627 PROS1

OMIM:176880 PROS1

UCSC:P07225 PROS1

Reference Transcript

Other Identifiers

11720133_a_at

11720134_s_at

11720135_a_at

16956569

17123302

17123306

17123308

17123310

207808_PM_s_at

207808_s_at

2685269

2685271

2685273

2685275

2685277

2685278

2685280

2685282

2685287

2685291

2685293

2685295

2685305

2685306

2685307

2685308

2685309

2685310

2685311

2685313

2685314

2685315

2685316

2685317

2685319

2685321

2685322

2685323

2685324

2685328

2685337

2685338

2685339

35752_s_at

5627

8089011

8089015

A_21_P0012453

A_23_P73114

A_24_P383480

GE57827

GO:0000139

GO:0004866

GO:0005509

GO:0005515

GO:0005576

GO:0005615

GO:0005783

GO:0005789

GO:0005794

GO:0005796

GO:0005886

GO:0007596

GO:0007599

GO:0031093

GO:0031410

GO:0042060

GO:0042730

GO:0043226

GO:0050896

GO:0070062

GO:0072562

GO:0098772

HMNXSV003050726

ILMN_1671928

M14338_at

PH_hs_0003988

TC03001590.hg

TC03002992.hg

TC03002994.hg

g4506116_3p_a_at

Participates

as an output of

Furin cleaves pro-protein S to protein S (Homo sapiens)

Other forms of this molecule

11xCbxE-PROS1 [platelet alpha granule lumen]

11xCbxE-PROS1 [extracellular region]

11xCbxE-PROS1 [plasma membrane]

PROS1(25-676) [endoplasmic reticulum membrane]

11xCbxE-PROS1(25-676) [endoplasmic reticulum membrane]

11xCbxE-PROS1(25-676) [Golgi membrane]

11xCbxE-PROS1 [Golgi membrane]

Inferred To

PROS1 [Golgi lumen] (Bos taurus)

PROS1 [Golgi lumen] (Canis familiaris)

PROS1 [Golgi lumen] (Sus scrofa)

pros1 [Golgi lumen] (Danio rerio)

pros1 [Golgi lumen] (Xenopus tropicalis)

Pros1 [Golgi lumen] (Mus musculus)

Pros1 [Golgi lumen] (Rattus norvegicus)

PROS1(25-41) [Golgi lumen] (Gallus gallus)

Cross References

RefSeq

NP_000304.2, NP_001301006.1

OpenTargets

ENSG00000184500

GeneCards

P07225

HPA

ENSG00000184500-PROS1

Ensembl

ENSP00000330021, ENST00000394236, ENSG00000184500, ENSP00000377783, ENST00000348974

PRO

P07225

Pharos - Targets

P07225

Orphanet

15148

HMDB Protein

HMDBP02003

PDB

1Z6C

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q5SUL5 1A01			0.556	3
UniProt:P62937-2 P629372			0.556	3
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.556	3
UniProt:Q96CV9 OPTN	6	OPTN [recycling endosome membrane] (R-HSA-8854141) p-S177-OPTN [nucleoplasm] (R-HSA-2562595) p-S177-OPTN [cytosol] (R-HSA-2562525) OPTN [Golgi membrane] (R-HSA-2161111) OPTN [cytosol] (R-HSA-9687907) p-S177,S473,S513-OPTN [cytosol] (R-HSA-9687840)	0.556	3
UniProt:Q8TAP4-4 LMO3			0.556	3
UniProt:Q15047-2 SETDB1			0.556	3
UniProt:Q92993 KAT5	1	KAT5 [nucleoplasm] (R-HSA-3321979)	0.556	3
UniProt:P17252 PRKCA	8	PRKCA [nucleoplasm] (R-HSA-450530) PRKCA [photoreceptor disc membrane] (R-HSA-2648987) PRKCA [cytosol] (R-HSA-58196) pT497,T638,S657-PRKCA [plasma membrane] (R-HSA-4332340) p-T497,T638,S657-PRKCA [cytosol] (R-HSA-4332337) PRKCA [plasma membrane] (R-HSA-156469) p-T497-PRKCA [cytosol] (R-HSA-5218731) p-T497,T638,S657-PRKCA [nucleoplasm] (R-HSA-5223292)	0.556	3
UniProt:Q96GX1 TCTN2	1	TCTN2 [ciliary membrane] (R-HSA-5626661)	0.527	2

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