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PROS1(25-41) [Golgi lumen]
Stable Identifier
R-HSA-159792
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Golgi lumen
Synonyms
protein S propeptide
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Gamma carboxylation, hypusine formation and arylsulfatase activation (Homo sapiens)
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins (Homo sapiens)
Removal of aminoterminal propeptides from gamma-carboxylated proteins (Homo sapiens)
Furin cleaves pro-protein S to protein S (Homo sapiens)
PROS1(25-41) [Golgi lumen] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
420821
Characterization of protein S, a gamma-carboxyglutamic acid containing protein from bovine and human plasma
DiScipio, RG
,
Davie, EW
Biochemistry
1979
External Reference Information
External Reference
UniProt:P07225 PROS1
Gene Names
PROS1, PROS
Chain
signal peptide:1-24, propeptide:25-41, chain:42-676
Reference Genes
BioGPS Gene:5627 PROS1
COSMIC (genes):PROS1 PROS1
CTD Gene:5627 PROS1
dbSNP Gene:5627 PROS1
ENSEMBL:ENSG00000184500 PROS1
HGNC:9456 PROS1
KEGG Gene (Homo sapiens):5627 PROS1
Monarch:5627 PROS1
NCBI Gene:5627 PROS1
OMIM:176880 PROS1
UCSC:P07225 PROS1
Reference Transcript
RefSeq:NM_001314077.1 PROS1
RefSeq:NM_000313.3 PROS1
Other Identifiers
0005550497
11720133_a_at
11720134_s_at
11720135_a_at
16956569
17123302
17123306
17123308
17123310
207808_s_at
2685269
2685271
2685273
2685275
2685277
2685278
2685280
2685282
2685287
2685291
2685293
2685295
2685305
2685306
2685307
2685308
2685309
2685310
2685311
2685313
2685314
2685315
2685316
2685317
2685319
2685321
2685322
2685323
2685324
2685328
2685337
2685338
2685339
35752_s_at
5627
8089011
8089015
A_21_P0012453
A_23_P73114
A_24_P383480
GE57827
GO:0000139
GO:0002376
GO:0002576
GO:0003674
GO:0004866
GO:0005509
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005737
GO:0005789
GO:0005794
GO:0005796
GO:0005886
GO:0006810
GO:0006888
GO:0006950
GO:0007596
GO:0007599
GO:0008150
GO:0010951
GO:0016192
GO:0030195
GO:0030234
GO:0030449
GO:0031093
GO:0031410
GO:0040011
GO:0042730
GO:0043167
GO:0043226
GO:0048870
GO:0050900
GO:0070062
GO:0072562
ILMN_1671928
M14338_at
PH_hs_0003988
TC03001590.hg
TC03002992.hg
TC03002994.hg
g4506116_3p_a_at
Participant Of
output
Furin cleaves pro-protein S to protein S
Other forms of this molecule
11xCbxE-PROS1 [extracellular region]
11xCbxE-PROS1 [plasma membrane]
PROS1(25-676) [endoplasmic reticulum membrane]
11xCbxE-PROS1(25-676) [endoplasmic reticulum membrane]
11xCbxE-PROS1(25-676) [Golgi membrane]
11xCbxE-PROS1 [Golgi membrane]
11xCbxE-PROS1 [platelet alpha granule lumen]
Inferred To
PROS1 [Golgi lumen] (Canis familiaris)
PROS1 [Golgi lumen] (Gallus gallus)
PROS1 [Golgi lumen] (Sus scrofa)
pros1 [Golgi lumen] (Danio rerio)
slc2a15a [Golgi lumen] (Xenopus tropicalis)
Pros1 [Golgi lumen] (Mus musculus)
Pros1 [Golgi lumen] (Rattus norvegicus)
Cross References
RefSeq
NP_000304.2
,
NP_001301006.1
OpenTargets
ENSG00000184500
HPA
ENSG00000184500-PROS1
GeneCards
P07225
Ensembl
ENSP00000330021
,
ENSG00000184500
,
ENST00000348974
,
ENST00000394236
,
ENSP00000377783
PRO
P07225
Orphanet
15148
HMDB Protein
HMDBP02003
PDB
1Z6C
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q5SUL5 1A01
0.556
3
UniProt:P62937-2 P629372
0.556
3
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.556
3
UniProt:Q8TAP4-4 LMO3
0.556
3
UniProt:Q15047-2 SETDB1
0.556
3
UniProt:Q92993 KAT5
1
KAT5 [nucleoplasm]
(R-HSA-3321979)
0.556
3
UniProt:P17252 PRKCA
8
p-T497,T638,S657-PRKCA [nucleoplasm]
(R-HSA-5223292)
PRKCA [cytosol]
(R-HSA-58196)
p-T497-PRKCA [cytosol]
(R-HSA-5218731)
p-T497,T638,S657-PRKCA [cytosol]
(R-HSA-4332337)
pT497,T638,S657-PRKCA [plasma membrane]
(R-HSA-4332340)
PRKCA [plasma membrane]
(R-HSA-156469)
PRKCA [photoreceptor disc membrane]
(R-HSA-2648987)
PRKCA [nucleoplasm]
(R-HSA-450530)
0.556
3
UniProt:Q96CV9 OPTN
4
OPTN [Golgi membrane]
(R-HSA-2161111)
OPTN [recycling endosome membrane]
(R-HSA-8854141)
p-S177-OPTN [nucleoplasm]
(R-HSA-2562595)
p-S177-OPTN [cytosol]
(R-HSA-2562525)
0.556
3
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