Reactome | GGCX gamma-carboxylates F7(21-466) (pro-factor VII)

GGCX gamma-carboxylates F7(21-466) (pro-factor VII)

Stable Identifier

R-HSA-159761

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen, endoplasmic reticulum membrane

Synonyms

pro-factor VII, uncarboxylated + 10 CO2 + 10 O2 + 10 vitamin K hydroquinone -> pro-factor VII + 10 H2O + 10 vitamin K epoxide

ReviewStatus

5/5

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GGCX gamma-carboxylates F7(21-466) (pro-factor VII)

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GGCX (gamma glutamyl carboxylase) in the endoplasmic reticulum gamma-carboxylates ten glutamate residues on F7(21-466) (pro-factor VII). MK4 (vitamin K hydroquinone) is oxidized to MK4 epoxide in the process (Berkner 2000; Furie et al. 1999; Stenina et al. 2001; Morris et al. 1995).

Literature References

PubMed ID	Title	Journal	Year
10068650	Vitamin K-dependent biosynthesis of gamma-carboxyglutamic acid Furie, B, Bouchard, BA, Furie, BC	Blood	1999
10917896	The vitamin K-dependent carboxylase Berkner, KL	J Nutr	2000
8530480	Processive post-translational modification. Vitamin K-dependent carboxylation of a peptide substrate. Morris, DP, Stevens, RD, Wright, DJ, Stafford, DW	J Biol Chem	1995
11513608	Tethered processivity of the vitamin K-dependent carboxylase: factor IX is efficiently modified in a mechanism which distinguishes Gla's from Glu's and which accounts for comprehensive carboxylation in vivo Stenina, O, Pudota, BN, McNally, BA, Hommema, EL, Berkner, KL	Biochemistry	2001