Furin cleaves pro-prothrombin to prothrombin

Stable Identifier
R-HSA-159728
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
pro-prothrombin -> prothrombin + prothrombin propeptide
ReviewStatus
5/5
Locations in the PathwayBrowser
General
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Furin, associated with the Golgi membrane, cleaves pro-prothrombin to form mature, gamma-carboxylated prothrombin (Wasley et al. 1993).
Literature References
PubMed ID Title Journal Year
8473289 PACE/furin can process the vitamin K-dependent pro-factor IX precursor within the secretory pathway

Kaufman, RJ, Wasley, LC, Bristol, JA, Rehemtulla, A

J. Biol. Chem. 1993
Participants
Participates
Catalyst Activity

serine-type endopeptidase activity of FURIN [Golgi membrane]

Orthologous Events
Created
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