Furin cleaves pro-prothrombin to prothrombin

Stable Identifier
R-HSA-159728
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Golgi membrane, Golgi lumen
Synonyms
pro-prothrombin -> prothrombin + prothrombin propeptide
ReviewStatus
5/5
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Furin cleaves pro-prothrombin to prothrombin
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Furin, associated with the Golgi membrane, cleaves pro-prothrombin to form mature, gamma-carboxylated prothrombin (Wasley et al. 1993).

Literature References
PubMed ID Title Journal Year
8473289 PACE/furin can process the vitamin K-dependent pro-factor IX precursor within the secretory pathway

Kaufman, RJ, Wasley, LC, Bristol, JA, Rehemtulla, A

J. Biol. Chem. 1993
Participants
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Output
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as an event of
Catalyst Activity

serine-type endopeptidase activity of FURIN [Golgi membrane]

Physical Entity
FURIN [Golgi membrane] (Homo sapiens)
Activity
serine-type endopeptidase activity (GO:0004252)
Orthologous Events
Furin cleaves pro-prothrombin to prothrombin (Bos taurus)
Furin cleaves pro-prothrombin to prothrombin (Canis familiaris)
Furin cleaves pro-prothrombin to prothrombin (Danio rerio)
Furin cleaves pro-prothrombin to prothrombin (Gallus gallus)
Furin cleaves pro-prothrombin to prothrombin (Mus musculus)
Furin cleaves pro-prothrombin to prothrombin (Rattus norvegicus)
Furin cleaves pro-prothrombin to prothrombin (Sus scrofa)
Created
D'Eustachio, P  (2005-03-17)
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