12xCbxE-3D-F9(29-461) [Golgi lumen]

Stable Identifier
R-HSA-159726
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Golgi lumen
Synonyms
pro-factor IX
Icon
12xCbxE-3D-F9(29-461) [Golgi lumen] icon
12xCbxE-3D-F9(29-461) [Golgi lumen] icon
Locations in the PathwayBrowser
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Literature References
PubMed ID Title Journal Year
2994716 Nucleotide sequence of the gene for human factor IX (antihemophilic factor B)

Yoshitake, S, Schach, BG, Foster, DC, Davie, EW, Kurachi, K

Biochemistry 1985
6688526 The occurrence of beta-hydroxyaspartic acid in the vitamin K-dependent blood coagulation zymogens

McMullen, BA, Fujikawa, K, Kisiel, W

Biochem Biophys Res Commun 1983
External Reference Information
External Reference
UniProt:P00740 F9
Gene Names
F9
Chain
signal peptide:1-28, propeptide:29-46, chain:47-461, chain:47-191, propeptide:192-226, chain:227-461
Reference Genes
BioGPS Gene:2158 F9
COSMIC (genes):F9 F9
CTD Gene:2158 F9
dbSNP Gene:2158 F9
ENSEMBL:ENSG00000101981 F9
HGNC:3551 F9
KEGG Gene (Homo sapiens):2158 F9
Monarch:2158 F9
NCBI Gene:2158 F9
OMIM:300746 F9
UCSC:P00740 F9
Reference Transcript
Other Identifiers
0001090301
11735185_a_at
11735186_a_at
11735187_at
11745643_a_at
17107373
207218_at
2158
35556_at
3993078
3993079
3993081
3993082
3993084
3993085
3993086
3993090
3993091
3993092
3993093
3993094
3993095
8170215
A_14_P113911
A_14_P200623
A_23_P62406
A_33_P3390411
GE80895
GO:0003674
GO:0004175
GO:0004252
GO:0005509
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005737
GO:0005783
GO:0005788
GO:0005794
GO:0005796
GO:0005886
GO:0006508
GO:0006810
GO:0006888
GO:0006950
GO:0007596
GO:0007597
GO:0007599
GO:0008150
GO:0008233
GO:0008236
GO:0016192
GO:0016787
GO:0031012
GO:0031638
GO:0043167
GO:0043226
GO:0046872
GO:0051604
GO:0062023
GO:0070062
ILMN_1787598
ILMN_1810651
K02402_at
PH_hs_0000181
TC0X000676.hg
g10518507_3p_at
Participant Of
input
output
Other forms of this molecule
F9(227-461) R384L [plasma membrane]
3OHD110-F9(29-461) N43L [endoplasmic reticulum lumen]
3OHD110-F9(29-461) N46S [endoplasmic reticulum lumen]
3OHD110-F9(29-461) N43Q [endoplasmic reticulum lumen]
3OHD110-F9(29-461) N43W [endoplasmic reticulum lumen]
12xCbxE-3D-F9(47-461) R191H [extracellular region]
F9(29-461) N43Q [extracellular region]
F9(29-461) N43W [extracellular region]
12xCbxE-3D-F9(47-461) R191C [extracellular region]
F9(29-461) N46S [extracellular region]
12xCbxE-3D-F9(47-461) R226W [extracellular region]
F9(29-461) N43L [extracellular region]
12xCbxE-3D-F9(47-461) R226Q [extracellular region]
12xCbxE-3D-F9(47-461) R226G [extracellular region]
F9(227-461) G409V [plasma membrane]
F9(227-461) I443T [plasma membrane]
F9(227-461) S411G [plasma membrane]
F9(227-461) G363E [plasma membrane]
F9(227-461) G363R [plasma membrane]
F9(227-461) D410H [plasma membrane]
F9(227-461) V359D [plasma membrane]
F9(227-461) G357E [plasma membrane]
F9(227-461) A436V [plasma membrane]
F9(227-461) S411I [plasma membrane]
F9(227-461) V419E [plasma membrane]
F9(227-461) G357R [plasma membrane]
F9(227-461) S411T [plasma membrane]
F9(29-461) R294* [endoplasmic reticulum lumen]
F9(29-461) R162R [endoplasmic reticulum lumen]
F9(29-461) Y450C [endoplasmic reticulum lumen]
F9(29-461) C28_V30delinsF [endoplasmic reticulum lumen]
F9(29-461) C155Y [endoplasmic reticulum lumen]
F9(29-461) C117Y [endoplasmic reticulum lumen]
F9(29-461) L163F [endoplasmic reticulum lumen]
F9(29-461) W453R [endoplasmic reticulum lumen]
F9(29-461) Q167H [endoplasmic reticulum lumen]
F9(29-461) R384* [endoplasmic reticulum lumen]
F9(29-461) A164V [endoplasmic reticulum lumen]
F9(29-461) V153V [endoplasmic reticulum lumen]
F9(29-461) R298* [endoplasmic reticulum lumen]
F9(29-461) R294Q [endoplasmic reticulum lumen]
F9(29-461) Y330* [endoplasmic reticulum lumen]
F9(29-461) T458K [endoplasmic reticulum lumen]
F9(29-461) R162* [endoplasmic reticulum lumen]
F9(29-461) C28* [endoplasmic reticulum lumen]
12xCbxE-3D-F9(47-461) [Golgi lumen]
factor IX propeptide [Golgi lumen]
12xCbxE-3D-F9(29-461) [endoplasmic reticulum lumen]
3OHD110-F9(29-461) [endoplasmic reticulum lumen]
F9(29-461) [endoplasmic reticulum lumen]
factor IX activation peptide [extracellular region]
factor IXa heavy chain [extracellular region]
12xCbxE-3D-F9(47-191) [extracellular region]
12xCbxE-3D-F9(47-461) [extracellular region]
12xCbxE-3D-F9(47-191) [plasma membrane]
factor IXa heavy chain [plasma membrane]
Inferred To
SPH161 [Golgi lumen] (Drosophila melanogaster)
f9 [Golgi lumen] (Xenopus tropicalis)
F9 [Golgi lumen] (Gallus gallus)
F9 [Golgi lumen] (Mus musculus)
F9 [Golgi lumen] (Rattus norvegicus)
Dmel\CG33458 [Golgi lumen] (Drosophila melanogaster)
HDC06756 [Golgi lumen] (Drosophila melanogaster)
f9b [Golgi lumen] (Danio rerio)
Homologues of 12xCbxE-3D-F9(29-461) [Golgi lumen] (Drosophila melanogaster)
Modified Residues
Name
L-gamma-carboxyglutamic acid at 86
Coordinate
86
PsiMod Name
L-gamma-carboxyglutamic acid [MOD:00041]
PsiMod Definition
A protein modification that effectively converts an L-glutamic acid residue to L-gamma-carboxyglutamic acid.
Name
L-gamma-carboxyglutamic acid at 82
Coordinate
82
PsiMod Name
L-gamma-carboxyglutamic acid [MOD:00041]
PsiMod Definition
A protein modification that effectively converts an L-glutamic acid residue to L-gamma-carboxyglutamic acid.
Name
L-gamma-carboxyglutamic acid at 79
Coordinate
79
PsiMod Name
L-gamma-carboxyglutamic acid [MOD:00041]
PsiMod Definition
A protein modification that effectively converts an L-glutamic acid residue to L-gamma-carboxyglutamic acid.
Name
L-gamma-carboxyglutamic acid at 76
Coordinate
76
PsiMod Name
L-gamma-carboxyglutamic acid [MOD:00041]
PsiMod Definition
A protein modification that effectively converts an L-glutamic acid residue to L-gamma-carboxyglutamic acid.
Name
L-gamma-carboxyglutamic acid at 73
Coordinate
73
PsiMod Name
L-gamma-carboxyglutamic acid [MOD:00041]
PsiMod Definition
A protein modification that effectively converts an L-glutamic acid residue to L-gamma-carboxyglutamic acid.
Name
L-gamma-carboxyglutamic acid at 72
Coordinate
72
PsiMod Name
L-gamma-carboxyglutamic acid [MOD:00041]
PsiMod Definition
A protein modification that effectively converts an L-glutamic acid residue to L-gamma-carboxyglutamic acid.
Name
L-gamma-carboxyglutamic acid at 67
Coordinate
67
PsiMod Name
L-gamma-carboxyglutamic acid [MOD:00041]
PsiMod Definition
A protein modification that effectively converts an L-glutamic acid residue to L-gamma-carboxyglutamic acid.
Name
L-gamma-carboxyglutamic acid at 66
Coordinate
66
PsiMod Name
L-gamma-carboxyglutamic acid [MOD:00041]
PsiMod Definition
A protein modification that effectively converts an L-glutamic acid residue to L-gamma-carboxyglutamic acid.
Name
L-gamma-carboxyglutamic acid at 63
Coordinate
63
PsiMod Name
L-gamma-carboxyglutamic acid [MOD:00041]
PsiMod Definition
A protein modification that effectively converts an L-glutamic acid residue to L-gamma-carboxyglutamic acid.
Name
L-gamma-carboxyglutamic acid at 61
Coordinate
61
PsiMod Name
L-gamma-carboxyglutamic acid [MOD:00041]
PsiMod Definition
A protein modification that effectively converts an L-glutamic acid residue to L-gamma-carboxyglutamic acid.
Name
L-gamma-carboxyglutamic acid at 54
Coordinate
54
PsiMod Name
L-gamma-carboxyglutamic acid [MOD:00041]
PsiMod Definition
A protein modification that effectively converts an L-glutamic acid residue to L-gamma-carboxyglutamic acid.
Name
L-gamma-carboxyglutamic acid at 53
Coordinate
53
PsiMod Name
L-gamma-carboxyglutamic acid [MOD:00041]
PsiMod Definition
A protein modification that effectively converts an L-glutamic acid residue to L-gamma-carboxyglutamic acid.
Name
(2S,3R)-3-hydroxyaspartic acid at 110
Coordinate
110
PsiMod Name
(2S,3R)-3-hydroxyaspartic acid [MOD:00036]
PsiMod Definition
A protein modification that effectively converts an L-aspartic acid residue to (2S,3R)-3-hydroxyaspartic acid.
Cross References
RefSeq
OpenTargets
ZINC - Substances
ZINC target
PRO
PDB
ZINC - Investigational
HPA
GeneCards
Ensembl
ZINC - Predictions - Purchasable
Orphanet
HMDB Protein
Interactors (2)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q3U4G3 XXLT1      0.618 3
 UniProt:P00451-PRO_0000002968 F8      0.544 2
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