Reactome | Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine

Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine

Stable Identifier

R-HSA-159431

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine

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Cytosolic bile acid-CoA conjugates (choloyl-CoA; chenodeoxycholoyl-CoA) react with the amino acids glycine and taurine, generating the corresponding bile salts and coenzyme A, catalyzed by BAAT (bile acid-CoA:amino acid N-acetyltransferase). In the body, this reaction occurs in hepatocytes and is the means by which bile acids recovered from the intestine are converted to bile salts before being released again into the bile (Kullak-Ublick et al. 2004; Trauner and Boyer 2002).

Literature References

PubMed ID	Title	Journal	Year
10884298	Subcellular organization of bile acid amidation in human liver: a key issue in regulating the biosynthesis of bile salts Ulvestad, A, Kase, BF, Solaas, K, Soreide, O	J Lipid Res	2000
2037576	Purification and characterization of bile acid-CoA:amino acid N-acyltransferase from human liver Barnes, S, Kwakye, JB, Johnson, MR, Diasio, RB	J Biol Chem	1991
8034703	Glycine and taurine conjugation of bile acids by a single enzyme. Molecular cloning and expression of human liver bile acid CoA:amino acid N-acyltransferase. Barnes, S, Johnson, MR, Diasio, RB, Falany, CN	J Biol Chem	1994