Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine

Stable Identifier
R-HSA-159431
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Cytosolic bile acid-CoA conjugates (choloyl-CoA; chenodeoxycholoyl-CoA) react with the amino acids glycine and taurine, generating the corresponding bile salts and coenzyme A, catalyzed by BAAT (bile acid-CoA:amino acid N-acetyltransferase). In the body, this reaction occurs in hepatocytes and is the means by which bile acids recovered from the intestine are converted to bile salts before being released again into the bile (Kullak-Ublick et al. 2004; Trauner and Boyer 2002).

Literature References
Participants
Participant Of
Event Information
Catalyst Activity
Catalyst Activity
Title
transferase activity, transferring acyl groups of BAAT [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
Cite Us!