SULT1A3,4 dimers sulfate DA to DAOS

Stable Identifier
Reaction [transition]
Homo sapiens
Dopamine can form an O-sulfate conjugate
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The catecholamine neurotransmitter dopamine (DA) is predominantly (>95%) conjugated with sulfate (dopamine 3-O-sulfate, DAOS) in human blood circulation. Human SULT1A3 and SULT1A4 are the major sulfotransferases that sulfonate DA (as well as other catecholamines and phenols) (Reiter et al. 1983, Johnson et al. 1980, Thomae et al. 2003, Hildebrandt et al. 2004).

Literature References
PubMed ID Title Journal Year
6770210 Radioenzymatic assay of sulfate conjugates of catecholamines and DOPA in plasma

Johnson, GA, Baker, CA, Smith, RT

Life Sci 1980
6139755 Thermolabile and thermostable human platelet phenol sulfotransferase. Substrate specificity and physical separation.

Reiter, C, Mwaluko, G, Dunnette, J, Van Loon, J, Weinshilboum, RM

Naunyn Schmiedebergs Arch Pharmacol 1983
15358107 Human SULT1A3 pharmacogenetics: gene duplication and functional genomic studies

Hildebrandt, MA, Salavaggione, OE, Martin, YN, Flynn, HC, Jalal, S, Wieben, ED, Weinshilboum, RM

Biochem. Biophys. Res. Commun. 2004
14622112 Human catecholamine sulfotransferase (SULT1A3) pharmacogenetics: functional genetic polymorphism

Thomae, BA, Rifki, OF, Theobald, MA, Eckloff, BW, Wieben, ED, Weinshilboum, RM

J. Neurochem. 2003
Catalyst Activity

aryl sulfotransferase activity of SULT1A3,4 dimers [cytosol]

Orthologous Events
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