Reactome | SULT1A3,4 dimers sulfate DA to DAOS

SULT1A3,4 dimers sulfate DA to DAOS

Stable Identifier

R-HSA-159358

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Dopamine can form an O-sulfate conjugate

ReviewStatus

5/5

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The catecholamine neurotransmitter dopamine (DA) is predominantly (>95%) conjugated with sulfate (dopamine 3-O-sulfate, DAOS) in human blood circulation. Human SULT1A3 and SULT1A4 are the major sulfotransferases that sulfonate DA (as well as other catecholamines and phenols) (Reiter et al. 1983, Johnson et al. 1980, Thomae et al. 2003, Hildebrandt et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
6139755	Thermolabile and thermostable human platelet phenol sulfotransferase. Substrate specificity and physical separation. Reiter, C, Mwaluko, G, Dunnette, J, Van Loon, J, Weinshilboum, RM	Naunyn Schmiedebergs Arch Pharmacol	1983
6770210	Radioenzymatic assay of sulfate conjugates of catecholamines and DOPA in plasma Johnson, GA, Baker, CA, Smith, RT	Life Sci	1980
15358107	Human SULT1A3 pharmacogenetics: gene duplication and functional genomic studies Hildebrandt, MA, Salavaggione, OE, Martin, YN, Flynn, HC, Jalal, S, Wieben, ED, Weinshilboum, RM	Biochem. Biophys. Res. Commun.	2004
14622112	Human catecholamine sulfotransferase (SULT1A3) pharmacogenetics: functional genetic polymorphism Thomae, BA, Rifki, OF, Theobald, MA, Eckloff, BW, Wieben, ED, Weinshilboum, RM	J. Neurochem.	2003