Initial activation of proMMP9 by MMPs

Stable Identifier
Reaction [transition]
Homo sapiens
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MMP1 (Sang et al. 1995), MMP2 (Fridman et al. 1995), MMP3 (Goldberg et al. 1992, Ogata et al. 1992, Okada et al. 1992), MMP7 (Imai et al. 1995, Sang et al. 1995), MMP10 (Nakamura et al. 1998) and MMP13 (Knauper et al. 1997) activate MMP9 by a stepwise mechanism but the second cleavage is apparently not an autocatalytic event as is the case for MMP1 (Okada et al. 1992). The first site is the Glu59-Met60 bond, generating an inactive 85-86 kDa intermediate (O'Connell et al. 1994), followed by cleavage of the Arg106-Phe107 peptide bond producing the fullly active 82 kDa form of MMP9 (Okada et al. 1992, Fridman et al. 1995).
Literature References
PubMed ID Title Journal Year
1371271 Matrix metalloproteinase 3 (stromelysin) activates the precursor for the human matrix metalloproteinase 9

Nagase, H, Ogata, Y, Enghild, JJ

J Biol Chem 1992
9346290 Activation of progelatinase B (proMMP-9) by active collagenase-3 (MMP-13)

Smith, B, López-Otin, C, Knäuper, V, Murphy, G

Eur J Biochem 1997
9578462 Activation of the precursor of human stromelysin 2 and its interactions with other matrix metalloproteinases

Fujii, Y, Okada, Y, Nakamura, H, Ohuchi, E, Yamamoto, E

Eur J Biochem 1998
1311314 Interaction of 92-kDa type IV collagenase with the tissue inhibitor of metalloproteinases prevents dimerization, complex formation with interstitial collagenase, and activation of the proenzyme with stromelysin

Marmer, BL, Genrich, LT, Strongin, A, Goldberg, GI, Collier, IE

J Biol Chem 1992
7669817 Proteolytic and non-proteolytic activation of human neutrophil progelatinase B

Sang, QX, Van Wart, HE, Birkedal-Hansen, H

Biochim Biophys Acta 1995
7780967 Activation of progelatinase B (MMP-9) by gelatinase A (MMP-2)

Peña, D, Fridman, R, Toth, M, Mobashery, S

Cancer Res 1995
7896811 Matrix metalloproteinase 7 (matrilysin) from human rectal carcinoma cells. Activation of the precursor, interaction with other matrix metalloproteinases and enzymic properties

Fujii, Y, Okada, Y, Imai, K, Yokohama, Y, Ohuchi, E, Nakanishi, I, Nakai, N

J Biol Chem 1995
Catalyst Activity

serine-type endopeptidase activity of MMP1 (2, 3, 7, 10, 13) [extracellular region]

Orthologous Events
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