Reactome | Initial activation of proMMP9 by MMPs

Initial activation of proMMP9 by MMPs

Stable Identifier

R-HSA-1592436

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

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MMP1 (Sang et al. 1995), MMP2 (Fridman et al. 1995), MMP3 (Goldberg et al. 1992, Ogata et al. 1992, Okada et al. 1992), MMP7 (Imai et al. 1995, Sang et al. 1995), MMP10 (Nakamura et al. 1998) and MMP13 (Knauper et al. 1997) activate MMP9 by a stepwise mechanism but the second cleavage is apparently not an autocatalytic event as is the case for MMP1 (Okada et al. 1992). The first site is the Glu59-Met60 bond, generating an inactive 85-86 kDa intermediate (O'Connell et al. 1994), followed by cleavage of the Arg106-Phe107 peptide bond producing the fullly active 82 kDa form of MMP9 (Okada et al. 1992, Fridman et al. 1995).

Literature References

PubMed ID	Title	Journal	Year
1371271	Matrix metalloproteinase 3 (stromelysin) activates the precursor for the human matrix metalloproteinase 9 Nagase, H, Ogata, Y, Enghild, JJ	J Biol Chem	1992
9346290	Activation of progelatinase B (proMMP-9) by active collagenase-3 (MMP-13) Smith, B, López-Otin, C, Knäuper, V, Murphy, G	Eur J Biochem	1997
9578462	Activation of the precursor of human stromelysin 2 and its interactions with other matrix metalloproteinases Fujii, Y, Okada, Y, Nakamura, H, Ohuchi, E, Yamamoto, E	Eur J Biochem	1998
1311314	Interaction of 92-kDa type IV collagenase with the tissue inhibitor of metalloproteinases prevents dimerization, complex formation with interstitial collagenase, and activation of the proenzyme with stromelysin Marmer, BL, Genrich, LT, Strongin, A, Goldberg, GI, Collier, IE	J Biol Chem	1992
7669817	Proteolytic and non-proteolytic activation of human neutrophil progelatinase B Sang, QX, Van Wart, HE, Birkedal-Hansen, H	Biochim Biophys Acta	1995
7780967	Activation of progelatinase B (MMP-9) by gelatinase A (MMP-2) Peña, D, Fridman, R, Toth, M, Mobashery, S	Cancer Res	1995
7896811	Matrix metalloproteinase 7 (matrilysin) from human rectal carcinoma cells. Activation of the precursor, interaction with other matrix metalloproteinases and enzymic properties Fujii, Y, Okada, Y, Imai, K, Yokohama, Y, Ohuchi, E, Nakanishi, I, Nakai, N	J Biol Chem	1995