Reactome | Fibulin binds elastic fibres

Fibulin binds elastic fibres

Stable Identifier

R-HSA-1592387

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

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Fibulins are a family of 7 genes encoding calcium binding glycoproteins with distinct roles in elastogenesis. They are essential for elastic fibre formation, having a role in regulating and organising tropoelastin formation (Yanagisawa & Davis 2010). Fibulins 1-5 all bind elastin (Roark et al. 1995, Sasaki et al. 1999, Kobayashi et al. 2007). Fibulins 2, 4, 5 and 7 also bind fibrillin (Reinhardt et al. 1996, El Hallous et al. 2007, de Vega et al. 2007). Fibulin 6 has a role in the formation of the cleavage furrow during cytokinesis but its binding partners are unclear (Xu & Vogel 2011).

Literature References

PubMed ID	Title	Journal	Year
7534784	The association of human fibulin-1 with elastic fibers: an immunohistological, ultrastructural, and RNA study Haudenschild, CC, Little, CD, Keene, DR, Roark, EF, Godyna, S, Argraves, WS	J Histochem Cytochem	1995
17324935	A comparative analysis of the fibulin protein family. Biochemical characterization, binding interactions, and tissue localization Hanisch, FG, Tsuda, T, Kobayashi, N, Kostka, G, Chu, ML, Bächinger, HP, Keene, DR, Markova, D, Sasaki, T, Garbe, JH, Timpl, R	J. Biol. Chem.	2007
10544250	Tropoelastin binding to fibulins, nidogen-2 and other extracellular matrix proteins Timpl, R, Miosge, N, Sasaki, T, Abrams, WR, Göhring, W, Rosenbloom, J	FEBS Lett.	1999