Fibulin binds elastic fibres

Stable Identifier
Reaction [binding]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Fibulins are a family of 7 genes encoding calcium binding glycoproteins with distinct roles in elastogenesis. They are essential for elastic fibre formation, having a role in regulating and organising tropoelastin formation (Yanagisawa & Davis 2010). Fibulins 1-5 all bind elastin (Roark et al. 1995, Sasaki et al. 1999, Kobayashi et al. 2007). Fibulins 2, 4, 5 and 7 also bind fibrillin (Reinhardt et al. 1996, El Hallous et al. 2007, de Vega et al. 2007). Fibulin 6 has a role in the formation of the cleavage furrow during cytokinesis but its binding partners are unclear (Xu & Vogel 2011).

Literature References
PubMed ID Title Journal Year
7534784 The association of human fibulin-1 with elastic fibers: an immunohistological, ultrastructural, and RNA study

Haudenschild, CC, Little, CD, Keene, DR, Roark, EF, Godyna, S, Argraves, WS

J Histochem Cytochem 1995
17324935 A comparative analysis of the fibulin protein family. Biochemical characterization, binding interactions, and tissue localization

Hanisch, FG, Tsuda, T, Kobayashi, N, Kostka, G, Chu, ML, Bächinger, HP, Keene, DR, Markova, D, Sasaki, T, Garbe, JH, Timpl, R

J. Biol. Chem. 2007
10544250 Tropoelastin binding to fibulins, nidogen-2 and other extracellular matrix proteins

Timpl, R, Miosge, N, Sasaki, T, Abrams, WR, Göhring, W, Rosenbloom, J

FEBS Lett. 1999
Orthologous Events
Cite Us!