proMMP3 is activated in a similar manner to pro MMP1 but by a large number of proteinases, including bacterial thermolysin, all cleaving within the region residues 51-56 (Woessner & Nagase 2000). This initiates autocatalysis and cleavage of the His99-Phe100 bond (Nagase et al. 1990, 1991). Residue numbering given here is based on the UniProt canonical sequence.
Lees, M, Woolley, DE, Nagase, H, Newlands, GF, Suzuki, K
Okada, Y, Harris ED, Jr, Nagase, H
serine-type endopeptidase activity of proMMP3 initial activators [extracellular region]
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