Initial activation of proMMP3

Stable Identifier
R-HSA-1592371
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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proMMP3 is activated in a similar manner to pro MMP1 but by a large number of proteinases, including bacterial thermolysin, all cleaving within the region residues 51-56 (Woessner & Nagase 2000). This initiates autocatalysis and cleavage of the His99-Phe100 bond (Nagase et al. 1990, 1991). Residue numbering given here is based on the UniProt canonical sequence.

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
serine-type endopeptidase activity of proMMP3 initial activators [extracellular region]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created