Full activation of MMP1

Stable Identifier
R-HSA-1592297
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The 42 kDa intermediate form of MMP1 is fully activated by cleavage of the Gln99-Phe100 bond, producing a 41 kDa protein. MMP2 (Crabbe et al. 1994), MMP3 (Suzuki et al. 1990, Nagase et al. 1992), MMP7 (Imai et al. 1995), MMP10 (Nicholson et al. 1989) and MMP11 (Murphy et al. 1993) are able to convert the 42 kDa intermediate to fully activated 41 kDa form though they are not able to initiate activation of proMMP1 effectively (Nagase et al. 1992). MMP3 regulates MMP1 collagenase activity in human rheumatoid synovial fibroblasts (Unemori et al. 1991).

Literature References
PubMed ID Title Journal Year
1480033 Activation mechanisms of the precursors of matrix metalloproteinases 1, 2 and 3

Nagase, H, Suzuki, K, Morodomi, T, Enghild, JJ, Salvesen, G

Matrix Suppl 1992
2169257 The role of matrix metalloproteinase 3 in the stepwise activation of human rheumatoid synovial procollagenase

Suzuki, K, Nagase, H, Ito, A, Enghild, JJ, Salvesen, G

Biol Chem Hoppe Seyler 1990
7981201 Reciprocated matrix metalloproteinase activation: a process performed by interstitial collagenase and progelatinase A

Crabbe, T, O'Connell, JP, Smith, BJ, Docherty, AJ

Biochemistry 1994
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
serine-type endopeptidase activity of MMP2,3,7,10,11 [extracellular region]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
Cite Us!