NID1 degradation by MMP1, 9, 12, ELANE

Stable Identifier
R-HSA-1592270
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
NID1 degradation by MMP1, 9, 12, ELANE
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Nidogen-1 (entactin) is a member of the nidogen family of basement membrane glycoproteins. It interacts with several other components of basement membranes, notably it connects the collagen and laminin networks to each other (Yurchenko & Patton 2009). MMPs 3, 7 (Mayer et al. 1993), 1, 9, (Sires et al. 1993), 12 (Gronski et al. 1997), 14, 15 (d'Ortho et al. 1997), 19 (Stracke et al. 2000) and leukocyte elastase (Mayer et al. 1993) can all degrade Nidogen-1.
Participants
Input
Output
Participates
as an event of
Catalyst Activity

serine-type endopeptidase activity of MMP1, MMP9, MMP12, ELANE [extracellular region]

Physical Entity
MMP1, MMP9, MMP12, ELANE [extracellular region] (Homo sapiens)
Activity
serine-type endopeptidase activity (GO:0004252)
Inferred From
Nid1 degradation by MMP1, 9, 12, ELANE (Homo sapiens)
Authored
Jupe, S  (2012-08-08)
Reviewed
Ricard-Blum, S  (2013-08-13)
Created
Jupe, S  (2011-09-09)
Cite Us!