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NRF2 [nucleoplasm]
Stable Identifier
R-HSA-1592226
Type
Complex
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
GABP, NRF-2, GABPA:GABPB1-1:GABPB1-2:GABPB1-3:GABPB1-4, NRF2 alpha:NRF2 beta-1:NRF2 beta-2:NRF2 gamma-1:NRF2 gamma-2
Locations in the PathwayBrowser
Expand all
Organelle biogenesis and maintenance (Homo sapiens)
Mitochondrial biogenesis (Homo sapiens)
Transcriptional activation of mitochondrial biogenesis (Homo sapiens)
Expression of GABPA (NRF2 alpha subunit) (Homo sapiens)
NRF2 [nucleoplasm] (Homo sapiens)
Expression of POLG2 (Homo sapiens)
NRF2 [nucleoplasm] (Homo sapiens)
Expression of POLRMT (Homo sapiens)
NRF2 [nucleoplasm] (Homo sapiens)
Expression of SSBP1 (Homo sapiens)
NRF2 [nucleoplasm] (Homo sapiens)
Expression of TFAM (Homo sapiens)
TFAM gene:NRF1:NRF2:p-PPARGC1A,PPRC1 [nucleoplasm] (Homo sapiens)
TFAM gene:NRF1:NRF2:PPRC1 [nucleoplasm] (Homo sapiens)
NRF2 [nucleoplasm] (Homo sapiens)
TFAM gene:NRF1:p-PPARGC1A:NRF2 [nucleoplasm] (Homo sapiens)
NRF2 [nucleoplasm] (Homo sapiens)
Expression of TFB1M (Homo sapiens)
TFB1M gene:NRF1:NRF2:p-PPARGC1A,PPRC1 [nucleoplasm] (Homo sapiens)
TFB1M gene:NRF1:NRF2:HCFC1:PPRC1 [nucleoplasm] (Homo sapiens)
NRF2 [nucleoplasm] (Homo sapiens)
TFB1M gene:NRF1:p-PPARGC1A:NRF2 [nucleoplasm] (Homo sapiens)
NRF2 [nucleoplasm] (Homo sapiens)
Expression of TFB2M (Homo sapiens)
TFB2M gene:NRF1:NRF2:p-PPARGC1A,PPRC1 [nucleoplasm] (Homo sapiens)
TFB2M gene:NRF1:NRF2:HCFC1:PPRC1 [nucleoplasm] (Homo sapiens)
NRF2 [nucleoplasm] (Homo sapiens)
TFB2M gene:NRF1:p-PPARGC1A:NRF2 [nucleoplasm] (Homo sapiens)
NRF2 [nucleoplasm] (Homo sapiens)
Expression of TWINKLE (TWNK, PEO1) (Homo sapiens)
NRF2 [nucleoplasm] (Homo sapiens)
Expression of mTERF (Homo sapiens)
NRF2 [nucleoplasm] (Homo sapiens)
Formation of NRF2 (Homo sapiens)
NRF2 [nucleoplasm] (Homo sapiens)
NRF1, PPRC1, NRF2 bind the TFAM promoter (Homo sapiens)
NRF2 [nucleoplasm] (Homo sapiens)
TFAM gene:NRF1:NRF2:PPRC1 [nucleoplasm] (Homo sapiens)
NRF2 [nucleoplasm] (Homo sapiens)
NRF1, PPRC1:HCFC1:NRF2 bind the TFB1M promoter (Homo sapiens)
NRF2 [nucleoplasm] (Homo sapiens)
TFB1M gene:NRF1:NRF2:HCFC1:PPRC1 [nucleoplasm] (Homo sapiens)
NRF2 [nucleoplasm] (Homo sapiens)
NRF1, PPRC1:HCFC1:NRF2 bind the TFB2M promoter (Homo sapiens)
NRF2 [nucleoplasm] (Homo sapiens)
TFB2M gene:NRF1:NRF2:HCFC1:PPRC1 [nucleoplasm] (Homo sapiens)
NRF2 [nucleoplasm] (Homo sapiens)
NRF1:p-PPARGC1A, NRF2 bind the TFAM promoter (Homo sapiens)
NRF2 [nucleoplasm] (Homo sapiens)
TFAM gene:NRF1:p-PPARGC1A:NRF2 [nucleoplasm] (Homo sapiens)
NRF2 [nucleoplasm] (Homo sapiens)
NRF1:p-PPARGC1A, NRF2 bind the TFB1M promoter (Homo sapiens)
NRF2 [nucleoplasm] (Homo sapiens)
TFB1M gene:NRF1:p-PPARGC1A:NRF2 [nucleoplasm] (Homo sapiens)
NRF2 [nucleoplasm] (Homo sapiens)
NRF1:p-PPARGC1A, NRF2 bind the TFB2M promoter (Homo sapiens)
NRF2 [nucleoplasm] (Homo sapiens)
TFB2M gene:NRF1:p-PPARGC1A:NRF2 [nucleoplasm] (Homo sapiens)
NRF2 [nucleoplasm] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
7799916
Four structurally distinct, non-DNA-binding subunits of human nuclear respiratory factor 2 share a conserved transcriptional activation domain
Virbasius, JV
,
Gugneja, S
,
Scarpulla, RC
Mol Cell Biol
1995
Participants
components
GABPA [nucleoplasm]
(Homo sapiens)
NRF2 beta-1 subunit [nucleoplasm]
(Homo sapiens)
NRF2 beta-2 subunit [nucleoplasm]
(Homo sapiens)
NRF2 gamma-1 subunit [nucleoplasm]
(Homo sapiens)
NRF2 gamma-2 subunit [nucleoplasm]
(Homo sapiens)
Participates
as an input of
NRF1:p-PPARGC1A, NRF2 bind the TFB1M promoter (Homo sapiens)
NRF1, PPRC1:HCFC1:NRF2 bind the TFB1M promoter (Homo sapiens)
NRF1:p-PPARGC1A, NRF2 bind the TFAM promoter (Homo sapiens)
NRF1, PPRC1, NRF2 bind the TFAM promoter (Homo sapiens)
NRF1:p-PPARGC1A, NRF2 bind the TFB2M promoter (Homo sapiens)
NRF1, PPRC1:HCFC1:NRF2 bind the TFB2M promoter (Homo sapiens)
as a component of
TFB1M gene:NRF1:p-PPARGC1A:NRF2 [nucleoplasm] (Homo sapiens)
TFB1M gene:NRF1:NRF2:HCFC1:PPRC1 [nucleoplasm] (Homo sapiens)
TFAM gene:NRF1:p-PPARGC1A:NRF2 [nucleoplasm] (Homo sapiens)
TFAM gene:NRF1:NRF2:PPRC1 [nucleoplasm] (Homo sapiens)
TFB2M gene:NRF1:p-PPARGC1A:NRF2 [nucleoplasm] (Homo sapiens)
TFB2M gene:NRF1:NRF2:HCFC1:PPRC1 [nucleoplasm] (Homo sapiens)
as an output of
Formation of NRF2 (Homo sapiens)
This entity regulates
Positively
Expression of TWINKLE (TWNK, PEO1)
(Homo sapiens)
Expression of POLG2
(Homo sapiens)
Expression of SSBP1
(Homo sapiens)
Expression of mTERF
(Homo sapiens)
Expression of POLRMT
(Homo sapiens)
Expression of GABPA (NRF2 alpha subunit)
(Homo sapiens)
Inferred To
NRF2 [nucleoplasm]
(Bos taurus)
NRF2 [nucleoplasm]
(Canis familiaris)
NRF2 [nucleoplasm]
(Danio rerio)
NRF2 [nucleoplasm]
(Dictyostelium discoideum)
NRF2 [nucleoplasm]
(Drosophila melanogaster)
NRF2 [nucleoplasm]
(Gallus gallus)
NRF2 [nucleoplasm]
(Mus musculus)
NRF2 [nucleoplasm]
(Plasmodium falciparum)
NRF2 [nucleoplasm]
(Rattus norvegicus)
NRF2 [nucleoplasm]
(Sus scrofa)
NRF2 [nucleoplasm]
(Xenopus tropicalis)
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