UGT1A4 transfers GlcA from UDP-GlcA to BMG to form BDG

Stable Identifier
R-HSA-159179
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
bilirubin monoglucuronide + UDP-glucuronic acid => bilirubin diglucuronide + UDP
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The principal conjugate of bilirubin in bile is bilirubin diglucuronide (BDG). UGT1A4 can transfer glucuronic acid (GlcA) to bilirubin (BIL) and bilirubin monoglucuronide (BMG) to form both the monoglucuronide and the diglucuronide (BDG) conjugates respectively (Ritter et al. 1992).

Literature References
PubMed ID Title Journal Year
1339448 A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini

Ritter, JK, Chen, F, Sheen, YY, Tran, HM, Kimura, S, Yeatman, MT, Owens, IS

J. Biol. Chem. 1992
Participants
Participates
Catalyst Activity

glucuronosyltransferase activity of UGT1A4 [endoplasmic reticulum membrane]

Orthologous Events
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