UGT1A4 transfers GlcA from UDP-GlcA to BMG to form BDG

Stable Identifier
R-HSA-159179
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endoplasmic reticulum lumen, endoplasmic reticulum membrane
Synonyms
bilirubin monoglucuronide + UDP-glucuronic acid => bilirubin diglucuronide + UDP
ReviewStatus
5/5
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UGT1A4 transfers GlcA from UDP-GlcA to BMG to form BDG
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The principal conjugate of bilirubin in bile is bilirubin diglucuronide (BDG). UGT1A4 can transfer glucuronic acid (GlcA) to bilirubin (BIL) and bilirubin monoglucuronide (BMG) to form both the monoglucuronide and the diglucuronide (BDG) conjugates respectively (Ritter et al. 1992).

Literature References
PubMed ID Title Journal Year
1339448 A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini

Owens, IS, Chen, F, Ritter, JK, Kimura, S, Sheen, YY, Yeatman, MT, Tran, HM

J. Biol. Chem. 1992
Participants
Input
Output
Participates
as an event of
Catalyst Activity

glucuronosyltransferase activity of UGT1A4 [endoplasmic reticulum membrane]

Physical Entity
UGT1A4 [endoplasmic reticulum membrane] (Homo sapiens)
Activity
glucuronosyltransferase activity (GO:0015020)
Orthologous Events
UGT1A4 transfers GlcA from UDP-GlcA to BMG to form BDG (Bos taurus)
UGT1A4 transfers GlcA from UDP-GlcA to BMG to form BDG (Gallus gallus)
UGT1A4 transfers GlcA from UDP-GlcA to BMG to form BDG (Mus musculus)
UGT1A4 transfers GlcA from UDP-GlcA to BMG to form BDG (Rattus norvegicus)
UGT1A4 transfers GlcA from UDP-GlcA to BMG to form BDG (Sus scrofa)
Authored
Jassal, B  (2005-02-23)
Reviewed
D'Eustachio, P  (2010-05-08)
Created
Jassal, B  (2005-02-23)
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