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ZBP1 [cytosol]
Stable Identifier
R-HSA-1591229
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
DAI, Z-DNA-binding protein 1, DNA-dependent activator of IFN-regulatory factors, DLM-1, C20orf183
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
Potential therapeutics for SARS (Homo sapiens)
TBK1 binds amlexanox (Homo sapiens)
TBK1:amlexanox [cytosol] (Homo sapiens)
dsDNA:ZBP1:pS-172-TBK1 [cytosol] (Homo sapiens)
dsDNA:ZBP1 [cytosol] (Homo sapiens)
ZBP1:ZBP1 [cytosol] (Homo sapiens)
ZBP1 [cytosol] (Homo sapiens)
dsDNA:ZBP1:pS-172-TBK1 [cytosol] (Homo sapiens)
dsDNA:ZBP1 [cytosol] (Homo sapiens)
ZBP1:ZBP1 [cytosol] (Homo sapiens)
ZBP1 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Cytosolic sensors of pathogen-associated DNA (Homo sapiens)
Regulation of innate immune responses to cytosolic DNA (Homo sapiens)
DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:dsDNA:ZBP1:TBK1 (Homo sapiens)
NLRP4:DTX4:dsDNA:ZBP1:pS-172-TBK1 [cytosol] (Homo sapiens)
dsDNA:ZBP1:pS-172-TBK1 [cytosol] (Homo sapiens)
dsDNA:ZBP1 [cytosol] (Homo sapiens)
ZBP1:ZBP1 [cytosol] (Homo sapiens)
ZBP1 [cytosol] (Homo sapiens)
dsDNA:ZBP1:pS-172,K48polyUb-TBK1 [cytosol] (Homo sapiens)
dsDNA:ZBP1 [cytosol] (Homo sapiens)
ZBP1:ZBP1 [cytosol] (Homo sapiens)
ZBP1 [cytosol] (Homo sapiens)
NLRP4 and DTX4 associate with p-S172-TBK1 within dsDNA:ZBP1:TBK1 (Homo sapiens)
NLRP4:DTX4:dsDNA:ZBP1:pS-172-TBK1 [cytosol] (Homo sapiens)
dsDNA:ZBP1:pS-172-TBK1 [cytosol] (Homo sapiens)
dsDNA:ZBP1 [cytosol] (Homo sapiens)
ZBP1:ZBP1 [cytosol] (Homo sapiens)
ZBP1 [cytosol] (Homo sapiens)
dsDNA:ZBP1:pS-172-TBK1 [cytosol] (Homo sapiens)
dsDNA:ZBP1 [cytosol] (Homo sapiens)
ZBP1:ZBP1 [cytosol] (Homo sapiens)
ZBP1 [cytosol] (Homo sapiens)
ZBP1(DAI) mediated induction of type I IFNs (Homo sapiens)
IRF3 mediated activation of type 1 IFN (Homo sapiens)
Phosphorylation and release of IRF3 (Homo sapiens)
NLRP4:DTX4:dsDNA:ZBP1:pS-172-TBK1 [cytosol] (Homo sapiens)
dsDNA:ZBP1:pS-172-TBK1 [cytosol] (Homo sapiens)
dsDNA:ZBP1 [cytosol] (Homo sapiens)
ZBP1:ZBP1 [cytosol] (Homo sapiens)
ZBP1 [cytosol] (Homo sapiens)
dsDNA:ZBP1:pS-172-TBK1 [cytosol] (Homo sapiens)
dsDNA:ZBP1 [cytosol] (Homo sapiens)
ZBP1:ZBP1 [cytosol] (Homo sapiens)
ZBP1 [cytosol] (Homo sapiens)
dsDNA:ZBP1:pS-172-TBK:IRF3 [cytosol] (Homo sapiens)
dsDNA:ZBP1:pS-172-TBK1 [cytosol] (Homo sapiens)
dsDNA:ZBP1 [cytosol] (Homo sapiens)
ZBP1:ZBP1 [cytosol] (Homo sapiens)
ZBP1 [cytosol] (Homo sapiens)
Recruitment TBK1 to dsDNA:ZBP1 followed by its activation (Homo sapiens)
dsDNA:ZBP1 [cytosol] (Homo sapiens)
ZBP1:ZBP1 [cytosol] (Homo sapiens)
ZBP1 [cytosol] (Homo sapiens)
dsDNA:ZBP1:pS-172-TBK1 [cytosol] (Homo sapiens)
dsDNA:ZBP1 [cytosol] (Homo sapiens)
ZBP1:ZBP1 [cytosol] (Homo sapiens)
ZBP1 [cytosol] (Homo sapiens)
Recruitment of IRF3 to activated ZBP1:TBK1 (Homo sapiens)
TBK1:amlexanox [cytosol] (Homo sapiens)
dsDNA:ZBP1:pS-172-TBK1 [cytosol] (Homo sapiens)
dsDNA:ZBP1 [cytosol] (Homo sapiens)
ZBP1:ZBP1 [cytosol] (Homo sapiens)
ZBP1 [cytosol] (Homo sapiens)
dsDNA:ZBP1:pS-172-TBK1 [cytosol] (Homo sapiens)
dsDNA:ZBP1 [cytosol] (Homo sapiens)
ZBP1:ZBP1 [cytosol] (Homo sapiens)
ZBP1 [cytosol] (Homo sapiens)
dsDNA:ZBP1:pS-172-TBK:IRF3 [cytosol] (Homo sapiens)
dsDNA:ZBP1:pS-172-TBK1 [cytosol] (Homo sapiens)
dsDNA:ZBP1 [cytosol] (Homo sapiens)
ZBP1:ZBP1 [cytosol] (Homo sapiens)
ZBP1 [cytosol] (Homo sapiens)
TBK1 binds amlexanox (Homo sapiens)
TBK1:amlexanox [cytosol] (Homo sapiens)
dsDNA:ZBP1:pS-172-TBK1 [cytosol] (Homo sapiens)
dsDNA:ZBP1 [cytosol] (Homo sapiens)
ZBP1:ZBP1 [cytosol] (Homo sapiens)
ZBP1 [cytosol] (Homo sapiens)
dsDNA:ZBP1:pS-172-TBK1 [cytosol] (Homo sapiens)
dsDNA:ZBP1 [cytosol] (Homo sapiens)
ZBP1:ZBP1 [cytosol] (Homo sapiens)
ZBP1 [cytosol] (Homo sapiens)
RIP-mediated NFkB activation via ZBP1 (Homo sapiens)
RIP1 facilitates IKK complex phosphorylation (Homo sapiens)
dsDNA:ZBP1:RIP1:RIP3 [cytosol] (Homo sapiens)
dsDNA:ZBP1 [cytosol] (Homo sapiens)
ZBP1:ZBP1 [cytosol] (Homo sapiens)
ZBP1 [cytosol] (Homo sapiens)
ZBP1(DAI) recruits RIP1 and RIP3 (Homo sapiens)
dsDNA:ZBP1 [cytosol] (Homo sapiens)
ZBP1:ZBP1 [cytosol] (Homo sapiens)
ZBP1 [cytosol] (Homo sapiens)
dsDNA:ZBP1:RIP1:RIP3 [cytosol] (Homo sapiens)
dsDNA:ZBP1 [cytosol] (Homo sapiens)
ZBP1:ZBP1 [cytosol] (Homo sapiens)
ZBP1 [cytosol] (Homo sapiens)
ZBP1 binds cytosolic DNA (Homo sapiens)
ZBP1 [cytosol] (Homo sapiens)
dsDNA:ZBP1 [cytosol] (Homo sapiens)
ZBP1:ZBP1 [cytosol] (Homo sapiens)
ZBP1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9H171 ZBP1
Gene Names
ZBP1, C20orf183, DLM1
Chain
chain:1-429
Reference Genes
BioGPS Gene:81030 ZBP1
COSMIC (genes):ZBP1 ZBP1
CTD Gene:81030 ZBP1
dbSNP Gene:81030 ZBP1
ENSEMBL:ENSG00000124256 ZBP1
HGNC:16176 ZBP1
KEGG:hsa:81030 ZBP1
Monarch:81030 ZBP1
NCBI Gene:81030 ZBP1
OMIM:606750 ZBP1
UCSC:Q9H171 ZBP1
Reference Transcript
RefSeq:NM_001160417.1 ZBP1
RefSeq:NM_001160419.2 ZBP1
RefSeq:NM_001160418.1 ZBP1
RefSeq:NM_030776.2 ZBP1
RefSeq:NM_001323966.1 ZBP1
Other Identifiers
11744768_a_at
11751056_a_at
16920651
208087_3p_s_at
208087_PM_s_at
208087_s_at
242020_PM_s_at
242020_s_at
3911189
3911190
3911191
3911192
3911193
3911194
3911195
3911196
3911197
3911198
3911200
3911201
3911202
3911203
3911204
3911205
3911206
3911207
3911208
3911209
3911210
3911211
8067221
81030
88416_at
A_23_P259141
A_24_P395966
A_33_P3357609
GE548063
GO:0002218
GO:0002376
GO:0003677
GO:0003692
GO:0003723
GO:0003725
GO:0003726
GO:0003824
GO:0005515
GO:0005634
GO:0005737
GO:0005829
GO:0006915
GO:0012501
GO:0016787
GO:0042802
GO:0043065
GO:0043226
GO:0045087
GO:0050727
GO:0050729
GO:0050832
GO:0051607
GO:0060340
GO:0060545
GO:0070269
GO:0098542
GO:0140374
GO:2000659
HMNXSV003011392
HMNXSV003036830
Hs.195098.0.A1_3p_s_at
ILMN_1765994
PH_hs_0015606
TC20000979.hg
g13540544_3p_x_at
Participates
as an input of
ZBP1 binds cytosolic DNA (Homo sapiens)
as a component of
ZBP1:ZBP1 [cytosol] (Homo sapiens)
Cross References
RefSeq
NP_001153890.1
,
NP_110403.2
,
NP_001153891.1
,
NP_001310895.1
,
NP_001153889.1
ENSEMBL
ENST00000395822
,
ENSP00000440552
,
ENST00000541799
,
ENSP00000379167
,
ENST00000371173
,
ENSP00000360215
OpenTargets
ENSG00000124256
HPA
ENSG00000124256-ZBP1
PRO
Q9H171
Pharos - Targets
Q9H171
PDB
2LNB
,
4KA4
,
3EYI
,
2L4M
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
IntAct:EBI-25847655 CCSB
0.556
3
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
6
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