Reactome | Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex

Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex

Stable Identifier

R-HSA-159050

Type

Reaction [dissociation]

Species

Homo sapiens

Compartment

cytosol, nuclear envelope

ReviewStatus

5/5

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Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex

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At some point eIF4E binds the mature mRNA. While TAP and Aly/Ref are released and will be reycled back to the nucleoplasm (Hung et al.2010, Lindtner et al. 2002).

Literature References

PubMed ID	Title	Journal	Year
12003494	An element in the 3' untranslated region of human LINE-1 retrotransposon mRNA binds NXF1(TAP) and can function as a nuclear export element Lindtner, S, Felber, BK, Kjems, J	RNA	2002
20129943	Arginine methylation of REF/ALY promotes efficient handover of mRNA to TAP/NXF1 Hung, ML, Hautbergue, GM, Snijders, AP, Dickman, MJ, Wilson, SA	Nucleic Acids Res.	2010