Reactome | urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 2 (PAI-2) -> PAI-2:urokinase plasminogen activator (two-chain):uPAR

urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 2 (PAI-2) -> PAI-2:urokinase plasminogen activator (two-chain):uPAR

Stable Identifier

R-HSA-159001

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 2 (PAI-2) -> PAI-2:urokinase plasminogen activator (two-chain):uPAR

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Activated (two-chain) urokinase plasminogen activator binds plasminogen activator inhibitor 2, a serpin, to form a stable, inactive complex that remains associated with uPAR on the plasma membrane (Estreicher et al. 1990; Kruithof et al. 1986).

Literature References

PubMed ID	Title	Journal	Year
3090045	Purification and characterization of a plasminogen activator inhibitor from the histiocytic lymphoma cell line U-937 Vassalli, JD, Bachmann, F, Mattaliano, RJ, Kruithof, EK, Schleuning, WD	J Biol Chem	1986
2166055	The receptor for urokinase type plasminogen activator polarizes expression of the protease to the leading edge of migrating monocytes and promotes degradation of enzyme inhibitor complexes Vassalli, JD, Orci, L, Carpentier, JL, Muhlhauser, J, Estreicher, A	J Cell Biol	1990