urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 2 (PAI-2) -> PAI-2:urokinase plasminogen activator (two-chain):uPAR

Stable Identifier
Reaction [transition]
Homo sapiens
SVG |   | PPTX  | SBGN
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Activated (two-chain) urokinase plasminogen activator binds plasminogen activator inhibitor 2, a serpin, to form a stable, inactive complex that remains associated with uPAR on the plasma membrane (Estreicher et al. 1990; Kruithof et al. 1986).

Literature References
PubMed ID Title Journal Year
3090045 Purification and characterization of a plasminogen activator inhibitor from the histiocytic lymphoma cell line U-937

Vassalli, JD, Bachmann, F, Mattaliano, RJ, Kruithof, EK, Schleuning, WD

J Biol Chem 1986
2166055 The receptor for urokinase type plasminogen activator polarizes expression of the protease to the leading edge of migrating monocytes and promotes degradation of enzyme inhibitor complexes

Vassalli, JD, Orci, L, Carpentier, JL, Muhlhauser, J, Estreicher, A

J Cell Biol 1990
Catalyst Activity

serine-type endopeptidase inhibitor activity of SERPINB2,6,8 [plasma membrane]

Orthologous Events
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