urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 2 (PAI-2) -> PAI-2:urokinase plasminogen activator (two-chain):uPAR

Stable Identifier
R-HSA-159001
Type
Reaction [transition]
Species
Homo sapiens
Compartment
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Activated (two-chain) urokinase plasminogen activator binds plasminogen activator inhibitor 2, a serpin, to form a stable, inactive complex that remains associated with uPAR on the plasma membrane (Estreicher et al. 1990; Kruithof et al. 1986).

Literature References
PubMed ID Title Journal Year
2166055 The receptor for urokinase type plasminogen activator polarizes expression of the protease to the leading edge of migrating monocytes and promotes degradation of enzyme inhibitor complexes

Estreicher, A, Muhlhauser, J, Carpentier, JL, Orci, L, Vassalli, JD

J Cell Biol 1990
3090045 Purification and characterization of a plasminogen activator inhibitor from the histiocytic lymphoma cell line U-937

Kruithof, EK, Vassalli, JD, Schleuning, WD, Mattaliano, RJ, Bachmann, F

J Biol Chem 1986
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
serine-type endopeptidase inhibitor activity of plasminogen activator inhibitor [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Created