plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst)

Stable Identifier
Reaction [transition]
Homo sapiens
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Plasminogen, tethered to the cell surface by its association with histidine-rich glycoprotein, is cleaved and activated to plasmin by the action of urokinase plasminogen activator bound to uPAR, its cell-surface receptor. The association of both substrate and enzyme with the cell surface is necessary for the reaction to proceed efficiently (Ellis et al. 1991). While the one-chain form of urokinase plasminogen activator is lower than that of the two-chain form, it is still sufficient to initiate the process of plasmin activation (Ellis et al. 1989; Lijnen et al. 1986).

Literature References
PubMed ID Title Journal Year
1829461 Plasminogen activation by receptor-bound urokinase. A kinetic study with both cell-associated and isolated receptor.

Ellis, V, Dano, K, Behrendt, N

J Biol Chem 1991
2521625 Plasminogen activation initiated by single-chain urokinase-type plasminogen activator. Potentiation by U937 monocytes.

Ellis, V, Kakkar, VV, Scully, MF

J Biol Chem 1989
2935528 Activation of plasminogen by pro-urokinase. I. Mechanism.

Collen, D, Blaber, M, Winkler, ME, Lijnen, HR, Zamarron, C

J Biol Chem 1986
Catalyst Activity

serine-type endopeptidase activity of PLAU(21-431):PI-PLAUR [plasma membrane]

Orthologous Events
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