Reactome | plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst)

plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst)

Stable Identifier

R-HSA-158982

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst)

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Plasminogen, tethered to the cell surface by its association with histidine-rich glycoprotein, is cleaved and activated to plasmin by the action of urokinase plasminogen activator bound to uPAR, its cell-surface receptor. The association of both substrate and enzyme with the cell surface is necessary for the reaction to proceed efficiently (Ellis et al. 1991). While the one-chain form of urokinase plasminogen activator is lower than that of the two-chain form, it is still sufficient to initiate the process of plasmin activation (Ellis et al. 1989; Lijnen et al. 1986).

Literature References

PubMed ID	Title	Journal	Year
1829461	Plasminogen activation by receptor-bound urokinase. A kinetic study with both cell-associated and isolated receptor. Ellis, V, Dano, K, Behrendt, N	J Biol Chem	1991
2521625	Plasminogen activation initiated by single-chain urokinase-type plasminogen activator. Potentiation by U937 monocytes. Ellis, V, Kakkar, VV, Scully, MF	J Biol Chem	1989
2935528	Activation of plasminogen by pro-urokinase. I. Mechanism. Collen, D, Blaber, M, Winkler, ME, Lijnen, HR, Zamarron, C	J Biol Chem	1986