urokinase plasminogen activator + urokinase plasminogen activator receptor (uPAR) -> urokinase plasminogen activator:uPAR

Stable Identifier
R-HSA-158959
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The uncleaved (one-chain) form of urokinase plasminogen activator associates with urokinase plasminogen activator receptor (uPAR), forming a complex at the cell surface (Cubellis et al. 1986). The complex is anchored to the outer face of the plasma membrane by a glycophosphatidylinositol moiety at the carboxy terminus of uPAR (Behrendt et al. 1990; Ploug et al. 1991).

Literature References
PubMed ID Title Journal Year
3023326 Binding of single-chain prourokinase to the urokinase receptor of human U937 cells

Cubellis, MV, Nolli, ML, Cassani, G, Blasi, F

J Biol Chem 1986
2156852 The human receptor for urokinase plasminogen activator. NH2-terminal amino acid sequence and glycosylation variants.

Behrendt, N, Ronne, E, Ploug, M, Petri, T, Lober, D, Nielsen, LS, Schleuning, WD, Blasi, F, Appella, E, Dano, K

J Biol Chem 1990
1846368 Cellular receptor for urokinase plasminogen activator. Carboxyl-terminal processing and membrane anchoring by glycosyl-phosphatidylinositol.

Ploug, M, Ronne, E, Behrendt, N, Jensen, AL, Blasi, F, Dano, K

J Biol Chem 1991
Participants
Participant Of
Orthologous Events
Authored
Created