urokinase plasminogen activator + urokinase plasminogen activator receptor (uPAR) -> urokinase plasminogen activator:uPAR

Stable Identifier
Reaction [binding]
Homo sapiens
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The uncleaved (one-chain) form of urokinase plasminogen activator associates with urokinase plasminogen activator receptor (uPAR), forming a complex at the cell surface (Cubellis et al. 1986). The complex is anchored to the outer face of the plasma membrane by a glycophosphatidylinositol moiety at the carboxy terminus of uPAR (Behrendt et al. 1990; Ploug et al. 1991).
Literature References
PubMed ID Title Journal Year
2156852 The human receptor for urokinase plasminogen activator. NH2-terminal amino acid sequence and glycosylation variants.

Ploug, M, Blasi, F, Nielsen, LS, Appella, E, Dano, K, Lober, D, Ronne, E, Schleuning, WD, Behrendt, N, Petri, T

J Biol Chem 1990
3023326 Binding of single-chain prourokinase to the urokinase receptor of human U937 cells

Blasi, F, Nolli, ML, Cubellis, MV, Cassani, G

J Biol Chem 1986
1846368 Cellular receptor for urokinase plasminogen activator. Carboxyl-terminal processing and membrane anchoring by glycosyl-phosphatidylinositol.

Ploug, M, Blasi, F, Dano, K, Ronne, E, Behrendt, N, Jensen, AL

J Biol Chem 1991
Orthologous Events
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