Reactome | urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR

urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR

Stable Identifier

R-HSA-158942

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR

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The small amount of plasmin generated by the activity of the one-chain form of urokinase plasminogen activator in turn cleaves urokinase plasminogen activator, converting it to its substantially more active two-chain form (Cubellis et al. 1986; Lijnen et al. 1991).

Literature References

PubMed ID	Title	Journal	Year
3023326	Binding of single-chain prourokinase to the urokinase receptor of human U937 cells Cubellis, MV, Nolli, ML, Cassani, G, Blasi, F	J Biol Chem	1986
2935528	Activation of plasminogen by pro-urokinase. I. Mechanism. Lijnen, HR, Zamarron, C, Blaber, M, Winkler, ME, Collen, D	J Biol Chem	1986