urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR

Stable Identifier
R-HSA-158942
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The small amount of plasmin generated by the activity of the one-chain form of urokinase plasminogen activator in turn cleaves urokinase plasminogen activator, converting it to its substantially more active two-chain form (Cubellis et al. 1986; Lijnen et al. 1991).
Literature References
PubMed ID Title Journal Year
3023326 Binding of single-chain prourokinase to the urokinase receptor of human U937 cells

Blasi, F, Nolli, ML, Cubellis, MV, Cassani, G

J Biol Chem 1986
2935528 Activation of plasminogen by pro-urokinase. I. Mechanism.

Collen, D, Blaber, M, Winkler, ME, Lijnen, HR, Zamarron, C

J Biol Chem 1986
Participants
Participates
Catalyst Activity

serine-type endopeptidase activity of Plasmin [extracellular region]

Orthologous Events
Authored
Created
Cite Us!