Reactome | plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst)

plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst)

Stable Identifier

R-HSA-158925

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst)

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Plasminogen, tethered to the cell surface by its association with histidine-rich glycoprotein, is rapidly cleaved and activated to plasmin by the action of urokinase plasminogen activator(two-chain form) bound to uPAR, its cell-surface receptor. The association of both substrate and enzyme with the cell surface is necessary for the reaction to proceed efficiently (Ellis et al. 1989, 1991).

Literature References

PubMed ID	Title	Journal	Year
1829461	Plasminogen activation by receptor-bound urokinase. A kinetic study with both cell-associated and isolated receptor. Ellis, V, Behrendt, N, Dano, K	J Biol Chem	1991
2521625	Plasminogen activation initiated by single-chain urokinase-type plasminogen activator. Potentiation by U937 monocytes. Ellis, V, Scully, MF, Kakkar, VV	J Biol Chem	1989