alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin

Stable Identifier
R-HSA-158893
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Plasmin binds the serpin alpha-2-antiplasmin, forming a stable and catalytically inactive complex. While several serpin proteins bind and inactivate plasmin in vitro, alpha-2-antiplasmin appears to be the only one with substantial plasmin-neutralizing activity in vivo (Moroi and Aoki 1976; Lijnen et al. 1987).

Literature References
PubMed ID Title Journal Year
134998 Isolation and characterization of alpha2-plasmin inhibitor from human plasma. A novel proteinase inhibitor which inhibits activator-induced clot lysis.

Moroi, M, Aoki, N

J Biol Chem 1976
2440681 Amino-acid sequence of human alpha 2-antiplasmin

Lijnen, HR, Holmes, WE, van Hoef, B, Wiman, B, Rodriguez, H

Eur J Biochem 1987
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
serine-type endopeptidase inhibitor activity of SERPINF2 [extracellular region]
Physical Entity
Activity
Orthologous Events
Authored
Created