Plasmin binds the serpin alpha-2-antiplasmin, forming a stable and catalytically inactive complex. While several serpin proteins bind and inactivate plasmin in vitro, alpha-2-antiplasmin appears to be the only one with substantial plasmin-neutralizing activity in vivo (Moroi and Aoki 1976; Lijnen et al. 1987).
Holmes, WE, Rodriguez, H, Lijnen, HR, van Hoef, B, Wiman, B
Moroi, M, Aoki, N
serine-type endopeptidase inhibitor activity of SERPINF2 [extracellular region]
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