Reactome | alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin

alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin

Stable Identifier

R-HSA-158893

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region

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alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin

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Plasmin binds the serpin alpha-2-antiplasmin, forming a stable and catalytically inactive complex. While several serpin proteins bind and inactivate plasmin in vitro, alpha-2-antiplasmin appears to be the only one with substantial plasmin-neutralizing activity in vivo (Moroi and Aoki 1976; Lijnen et al. 1987).

Literature References

PubMed ID	Title	Journal	Year
134998	Isolation and characterization of alpha2-plasmin inhibitor from human plasma. A novel proteinase inhibitor which inhibits activator-induced clot lysis. Moroi, M, Aoki, N	J Biol Chem	1976
2440681	Amino-acid sequence of human alpha 2-antiplasmin Lijnen, HR, Holmes, WE, van Hoef, B, Wiman, B, Rodriguez, H	Eur J Biochem	1987