Reactome | alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin

alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin

Stable Identifier

R-HSA-158893

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Plasmin binds the serpin alpha-2-antiplasmin, forming a stable and catalytically inactive complex. While several serpin proteins bind and inactivate plasmin in vitro, alpha-2-antiplasmin appears to be the only one with substantial plasmin-neutralizing activity in vivo (Moroi and Aoki 1976; Lijnen et al. 1987).

Literature References

PubMed ID	Title	Journal	Year
2440681	Amino-acid sequence of human alpha 2-antiplasmin Holmes, WE, Rodriguez, H, Lijnen, HR, van Hoef, B, Wiman, B	Eur J Biochem	1987
134998	Isolation and characterization of alpha2-plasmin inhibitor from human plasma. A novel proteinase inhibitor which inhibits activator-induced clot lysis. Moroi, M, Aoki, N	J Biol Chem	1976