SULT1A1 dimer sulfonates NHABP

Stable Identifier
R-HSA-158860
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
N-hydroxy-4-aminobiphenyl can form a sulfate conjugate
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N-hydroxy-4-aminobiphenyl (NHABP) is a genotoxic metabolite of an industrial carcinogen no longer used in the rubber industry. It can be sulfonated in the liver by cytosolic sulfotransferase 1A1 (SULT1A1) (Yamazoe et al. 1999, Weinshilboum et al. 1997, Strott 2002).

Literature References
PubMed ID Title Journal Year
12372849 Sulfonation and molecular action

Strott, CA

Endocr Rev 2002
9034160 Sulfation and sulfotransferases 1: Sulfotransferase molecular biology: cDNAs and genes

Weinshilboum, RM, Otterness, DM, Aksoy, IA, Wood, TC, Her, C, Raftogianis, RB

FASEB J 1997
10503886 Sulfotransferase catalyzing sulfation of heterocyclic amines

Yamazoe, Y, Nagata, K, Yoshinari, K, Fujita, K, Shiraga, T, Iwasaki, K

Cancer Lett 1999
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
aryl sulfotransferase activity of SULT1A1 dimer [cytosol]
Physical Entity
Activity
Orthologous Events
Reviewed
Created
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