fibrin multimer, crosslinked -> fibrin digestion products (plasmin)

Stable Identifier
R-HSA-158766
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
5/5
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fibrin multimer, crosslinked -> fibrin digestion products (plasmin)
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Plasmin, generated at the surfaces of the fibrin clot by tissue plasminogen activator or at the surfaces of cells by urokinase plasminogen activator, catalyzes the hydrolysis of fibrin to soluble fragments (Chapman 1997).
Literature References
PubMed ID Title Journal Year
2318848 Characterization of the gene for human plasminogen, a key proenzyme in the fibrinolytic system

Petersen, TE, Martzen, MR, Ichinose, A, Davie, EW

J Biol Chem 1990
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Catalyst Activity

serine-type endopeptidase activity of Plasmin [extracellular region]

Physical Entity
Plasmin [extracellular region] (Homo sapiens)
Activity
serine-type endopeptidase activity (GO:0004252)
Orthologous Events
fibrin multimer, crosslinked -> fibrin digestion products (plasmin) (Bos taurus)
fibrin multimer, crosslinked -> fibrin digestion products (plasmin) (Caenorhabditis elegans)
fibrin multimer, crosslinked -> fibrin digestion products (plasmin) (Canis familiaris)
fibrin multimer, crosslinked -> fibrin digestion products (plasmin) (Danio rerio)
fibrin multimer, crosslinked -> fibrin digestion products (plasmin) (Gallus gallus)
fibrin multimer, crosslinked -> fibrin digestion products (plasmin) (Mus musculus)
fibrin multimer, crosslinked -> fibrin digestion products (plasmin) (Rattus norvegicus)
fibrin multimer, crosslinked -> fibrin digestion products (plasmin) (Sus scrofa)
fibrin multimer, crosslinked -> fibrin digestion products (plasmin) (Xenopus tropicalis)
Authored
D'Eustachio, P  (2005-02-09)
Created
D'Eustachio, P  (2005-02-09)
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