crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin

Stable Identifier
R-HSA-158744
Type
Reaction [transition]
Species
Homo sapiens
Compartment
General
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At the beginning of this reaction, 1 molecule of 'fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen' is present. At the end of this reaction, 1 molecule of 'plasmin', and 1 molecule of 'fibrin multimer, crosslinked:tissue plasminogen activator (two-chain)' are present.

This reaction takes place in the 'extracellular region' and is mediated by the 'plasminogen activator activity' of 'fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen'.

Literature References
PubMed ID Title Journal Year
2318848 Characterization of the gene for human plasminogen, a key proenzyme in the fibrinolytic system

Petersen, TE, Martzen, MR, Ichinose, A, Davie, EW

J Biol Chem 1990
2962641 Interaction of one-chain and two-chain tissue plasminogen activator with intact and plasmin-degraded fibrin

Higgins, DL, Vehar, GA

Biochemistry 1987
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
serine-type endopeptidase activity of fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen [extracellular region]
Physical Entity
Activity
Orthologous Events
Created