Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Release of the SLBP independent Histone mRNA from the NPC
Stable Identifier
R-HSA-158484
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
cytosol
,
nuclear envelope
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
Metabolism of RNA (Homo sapiens)
Processing of Capped Intron-Containing Pre-mRNA (Homo sapiens)
Transport of Mature Transcript to Cytoplasm (Homo sapiens)
Transport of Mature mRNAs Derived from Intronless Transcripts (Homo sapiens)
Transport of the SLBP independent Mature mRNA (Homo sapiens)
Release of the SLBP independent Histone mRNA from the NPC (Homo sapiens)
General
SBML
|
BioPAX
Level 2
Level 3
|
PDF
SVG
|
PNG
Low
Medium
High
|
PPTX
|
SBGN
Click the image above or
here
to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
At some point eIF4E binds the mature mRNA. While TAP and Aly/Ref are released and will be reycled back to the nucleoplasm (Hung et al.2010, Lindtner et al. 2002).
Literature References
PubMed ID
Title
Journal
Year
12003494
An element in the 3' untranslated region of human LINE-1 retrotransposon mRNA binds NXF1(TAP) and can function as a nuclear export element
Kjems, J
,
Felber, BK
,
Lindtner, S
RNA
2002
22732409
Human intronless genes: functional groups, associated diseases, evolution, and mRNA processing in absence of splicing
Grzybowska, EA
Biochem. Biophys. Res. Commun.
2012
Participants
Input
EIF4E [cytosol]
(Homo sapiens)
Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex [cytosol]
(Homo sapiens)
Output
ALYREF [cytosol]
(Homo sapiens)
Mature SLBP independent Histone mRNA:eIF4E complex [cytosol]
(Homo sapiens)
NXF1 [cytosol]
(Homo sapiens)
Participates
as an event of
Transport of the SLBP independent Mature mRNA (Homo sapiens)
Event Information
Go Biological Process
mRNA export from nucleus (0006406)
This event is regulated
Requirements
Requirement by 'Nuclear Pore Complex (NPC) [nuclear envelope]'
Orthologous Events
Release of the SLBP independent Histone mRNA from the NPC (Bos taurus)
Release of the SLBP independent Histone mRNA from the NPC (Canis familiaris)
Release of the SLBP independent Histone mRNA from the NPC (Drosophila melanogaster)
Release of the SLBP independent Histone mRNA from the NPC (Gallus gallus)
Release of the SLBP independent Histone mRNA from the NPC (Mus musculus)
Release of the SLBP independent Histone mRNA from the NPC (Rattus norvegicus)
Release of the SLBP independent Histone mRNA from the NPC (Schizosaccharomyces pombe)
Release of the SLBP independent Histone mRNA from the NPC (Sus scrofa)
Authored
Gillespie, ME (2005-01-27)
Created
Gillespie, ME (2005-01-27)
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text