Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC

Stable Identifier
R-HSA-158447
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
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The cytoplasmic 3' polyadenylated, capped intronless mRNA and TAP are released from the NPC into the cytosol. Cytosolic TAP will be recycled to the nucleous, while the 3' polyadenylated, capped intronless mRNA is bound by eIF4E and destined for translation (Carmody and Wente 2009, Wente and Rout 2010, Hetten and Kehlenbach 2007).

Literature References
PubMed ID Title Journal Year
20630994 The nuclear pore complex and nuclear transport

Wente, SR, Rout, MP

Cold Spring Harb Perspect Biol 2010
17317185 CRM1-mediated nuclear export: to the pore and beyond

Hutten, S, Kehlenbach, RH

Trends Cell Biol. 2007
19494120 mRNA nuclear export at a glance

Carmody, SR, Wente, SR

J. Cell. Sci. 2009
23582887 Aiding and abetting cancer: mRNA export and the nuclear pore

Culjkovic-Kraljacic, B, Borden, KL

Trends Cell Biol. 2013
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Orthologous Events
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