Reactome | kallikrein binds SERPING1

kallikrein binds SERPING1

Stable Identifier

R-HSA-158399

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

kallikrein + C1Inh -> kallikrein:C1Inh

ReviewStatus

5/5

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Activated kallikrein binds to C1Inh (plasma protease C1 inhibitor, SERPING1) (Bock et al. 1986), forming a stable and enzymatically inactive complex. This reaction appears to be the major means by which kallikrein is inactivated (kallikrein can also be inactivated by binding to alpha2-macroglobulin) (Harpel et al. 1985; Ratnoff et al. 1969).

Literature References

PubMed ID	Title	Journal	Year
3756141	Human C1 inhibitor: primary structure, cDNA cloning, and chromosomal localization Nielsen, E, Marrinan, J, Donaldson, VH, Thogersen, HC, Skriver, K, Eddy, RL, Magnusson, S, Bock, SC, Wiman, B, Huber, R, Radziejewska, E	Biochemistry	1986
2579948	Distribution of plasma kallikrein between C-1 inactivator and alpha 2-macroglobulin in plasma utilizing a new assay for alpha 2-macroglobulin-kallikrein complexes Harpel, PC, Lewin, MF, Kaplan, AP	J Biol Chem	1985
4178758	The inhibition of plasmin, plasma kallikrein, plasma permeability factor, and the C'1r subcomponent of the first component of complement by serum C'1 esterase inhibitor Naff, GB, Ogston, D, Pensky, J, Ratnoff, OD	J Exp Med	1969