kininogen + C1q binding protein tetramer -> kininogen:C1q binding protein tetramer

Stable Identifier
R-HSA-158354
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
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kininogen + C1q binding protein tetramer -> kininogen:C1q binding protein tetramer
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Kininogen (high molecular weight kininogen; HK) associates with C1q binding protein on the cell surface in a reaction dependent on Zn++ (Joseph et al. 1996). In the body, the Zn++ needed to drive this reaction may be provided locally by Zn++ release from activated platelets (Mahdi et al. 2002). The C1q binding protein is inferred to form tetramers based on the properties of purified recombinant protein in vitro (Ghebrehiwet et al. 1994); the stoichiometry of the cell surface complex has not been determined directly.
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Orthologous Events
kininogen + C1q binding protein tetramer -> kininogen:C1q binding protein tetramer (Bos taurus)
kininogen + C1q binding protein tetramer -> kininogen:C1q binding protein tetramer (Canis familiaris)
kininogen + C1q binding protein tetramer -> kininogen:C1q binding protein tetramer (Gallus gallus)
kininogen + C1q binding protein tetramer -> kininogen:C1q binding protein tetramer (Mus musculus)
kininogen + C1q binding protein tetramer -> kininogen:C1q binding protein tetramer (Rattus norvegicus)
kininogen + C1q binding protein tetramer -> kininogen:C1q binding protein tetramer (Sus scrofa)
kininogen + C1q binding protein tetramer -> kininogen:C1q binding protein tetramer (Xenopus tropicalis)
Authored
D'Eustachio, P  (2005-01-20)
Created
D'Eustachio, P  (2005-01-20)
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