The cleavage of kininogen (HK, high molecular weight kininogen) yields activated kininogen and the vasoactive peptide bradykinin (Kerbirou and Griffin 1979; Lottspeich et al. 1985; Kellerman et al. 1986). In vivo, this reaction is catalyzed by activated kallikrein, takes places within the kallikrein:kininogen:C1q binding protein tetramer complex on the endothelial cell surface, and results in the release of kallikrein and bradykinin (Motta et al. 1998).
Muller-Esterl, W, Lottspeich, F, Henschen, A, Kellermann, J
Kerbiriou, DM, Griffin, JH
Foertsch, B, Muller-Esterl, W, Lottspeich, F, Henschen, A, Kellermann, J
Schmaier, AH, Cines, DB, Rojkjaer, R, Hasan, AA, Motta, G
serine-type endopeptidase activity of kallikrein:kininogen:C1q binding protein tetramer [plasma membrane]
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