The cleavage of kininogen (HK, high molecular weight kininogen) yields activated kininogen and the vasoactive peptide bradykinin (Kerbirou and Griffin 1979; Lottspeich et al. 1985; Kellerman et al. 1986). In vivo, this reaction is catalyzed by activated kallikrein, takes places within the kallikrein:kininogen:C1q binding protein tetramer complex on the endothelial cell surface, and results in the release of kallikrein and bradykinin (Motta et al. 1998).
Kerbiriou, DM, Griffin, JH
Kellermann, J, Lottspeich, F, Henschen, A, Muller-Esterl, W
Lottspeich, F, Kellermann, J, Henschen, A, Foertsch, B, Muller-Esterl, W
Motta, G, Rojkjaer, R, Hasan, AA, Cines, DB, Schmaier, AH
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