Reactome | kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin

kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin

Stable Identifier

R-HSA-158311

Type

Reaction

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

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kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin

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The cleavage of kininogen (HK, high molecular weight kininogen) yields activated kininogen and the vasoactive peptide bradykinin (Kerbirou and Griffin 1979; Lottspeich et al. 1985; Kellerman et al. 1986). In vivo, this reaction is catalyzed by activated kallikrein, takes places within the kallikrein:kininogen:C1q binding protein tetramer complex on the endothelial cell surface, and results in the release of kallikrein and bradykinin (Motta et al. 1998).

Literature References

PubMed ID	Title	Journal	Year
3484703	Completion of the primary structure of human high-molecular-mass kininogen. The amino acid sequence of the entire heavy chain and evidence for its evolution by gene triplication. Muller-Esterl, W, Lottspeich, F, Henschen, A, Kellermann, J	Eur J Biochem	1986
500690	Human high molecular weight kininogen. Studies of structure-function relationships and of proteolysis of the molecule occurring during contact activation of plasma. Kerbiriou, DM, Griffin, JH	J Biol Chem	1979
4054110	The amino acid sequence of the light chain of human high-molecular-mass kininogen Foertsch, B, Muller-Esterl, W, Lottspeich, F, Henschen, A, Kellermann, J	Eur J Biochem	1985
9427705	High molecular weight kininogen regulates prekallikrein assembly and activation on endothelial cells: a novel mechanism for contact activation Schmaier, AH, Cines, DB, Rojkjaer, R, Hasan, AA, Motta, G	Blood	1998