Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
factor VIII light chain [extracellular region]
Stable Identifier
R-HSA-158299
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
F8(1668-2351)
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of hemostasis (Homo sapiens)
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) (Homo sapiens)
Defective factor VIII causes hemophilia A (Homo sapiens)
Defective F8 cleavage by thrombin (Homo sapiens)
F8 variant is not cleaved by thrombin (Homo sapiens)
FVIII variant:vWF multimer [extracellular region] (Homo sapiens)
F8 thrombin cleavage site variant [extracellular region] (Homo sapiens)
F8 heavy chain thrombin cleavage site variants [extracellular region] (Homo sapiens)
factor VIII light chain [extracellular region] (Homo sapiens)
Hemostasis (Homo sapiens)
Formation of Fibrin Clot (Clotting Cascade) (Homo sapiens)
Intrinsic Pathway of Fibrin Clot Formation (Homo sapiens)
FVIII is secreted (Homo sapiens)
factor VIII [extracellular region] (Homo sapiens)
factor VIII light chain [extracellular region] (Homo sapiens)
factor VIII + von Willebrand factor multimer -> factor VIII:von Willibrand factor multimer (Homo sapiens)
factor VIII [extracellular region] (Homo sapiens)
factor VIII light chain [extracellular region] (Homo sapiens)
factor VIII:von Willebrand factor multimer [extracellular region] (Homo sapiens)
factor VIII [extracellular region] (Homo sapiens)
factor VIII light chain [extracellular region] (Homo sapiens)
factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer (Homo sapiens)
factor VIII:von Willebrand factor multimer [extracellular region] (Homo sapiens)
factor VIII [extracellular region] (Homo sapiens)
factor VIII light chain [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P00451 F8
Gene Names
F8, F8C
Chain
signal peptide:1-19, chain:20-2351, chain:20-1332, chain:20-759, chain:760-1332, chain:1668-2351
Reference Genes
BioGPS Gene:2157 F8
COSMIC (genes):F8 F8
CTD Gene:2157 F8
dbSNP Gene:2157 F8
ENSEMBL:ENSG00000185010 F8
HGNC:3546 F8
KEGG Gene (Homo sapiens):2157 F8
Monarch:2157 F8
NCBI Gene:2157 F8
OMIM:300841 F8
UCSC:P00451 F8
Reference Transcript
RefSeq:NM_000132.3 F8
RefSeq:NM_019863.2 F8
Other Identifiers
0002690746
0003140338
0004200086
11722979_a_at
11722980_a_at
11752341_a_at
17115729
205756_s_at
2157
37550_at
4027640
4027641
4027642
4027643
4027644
4027645
4027646
4027648
4027649
4027650
4027651
4027652
4027659
4027660
4027661
4027662
4027663
4027664
4027665
4027666
4027667
4027668
4027669
4027670
4027672
4027674
4027675
4027676
4027677
4027678
4027680
4027681
4027682
4027683
4027686
4027689
4027690
4027691
8176193
A_23_P217643
A_24_P314451
GE57825
GO:0000139
GO:0002576
GO:0003674
GO:0005507
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005737
GO:0005783
GO:0005788
GO:0005794
GO:0005886
GO:0006810
GO:0006888
GO:0006950
GO:0006953
GO:0007596
GO:0007597
GO:0007599
GO:0008150
GO:0016192
GO:0016491
GO:0022607
GO:0030134
GO:0030168
GO:0031093
GO:0031410
GO:0033116
GO:0043167
GO:0043226
GO:0046872
GO:0048208
GO:0055114
GO:0061024
GO:0065003
ILMN_1670229
ILMN_1675083
ILMN_1691584
ILMN_2370622
ILMN_3233263
M14113_at
PH_hs_0024930
TC0X001547.hg
g10518504_3p_a_at
Participant Of
hasComponent
F8 heavy chain thrombin cleavage site variants [extracellular region]
factor VIII [extracellular region]
Other forms of this molecule
Factor VIII precursor [extracellular region]
Coagulation factor VIII precursor [platelet alpha granule lumen]
F8(392-759) D579A [plasma membrane]
F8(392-759) V578A [plasma membrane]
F8(392-759) R546W [plasma membrane]
F8(392-759) S577F [plasma membrane]
F8(392-759) I585T [plasma membrane]
F8 N637S [endoplasmic reticulum lumen]
F8 G2013R [endoplasmic reticulum lumen]
F8 W604R [endoplasmic reticulum lumen]
F8 R1126W [endoplasmic reticulum lumen]
F8 R2326L [endoplasmic reticulum lumen]
F8 P947R [endoplasmic reticulum lumen]
F8 H1066Y [endoplasmic reticulum lumen]
F8 S603G [endoplasmic reticulum lumen]
F8 E1057K [endoplasmic reticulum lumen]
F8 E600D [endoplasmic reticulum lumen]
F8 W604C [endoplasmic reticulum lumen]
F8 D845E [endoplasmic reticulum lumen]
F8 G720S [endoplasmic reticulum lumen]
F8 E600Q [endoplasmic reticulum lumen]
F8 R2326Q [endoplasmic reticulum lumen]
F8 R602G [endoplasmic reticulum lumen]
F8 A1610S [endoplasmic reticulum lumen]
F8 D599H [endoplasmic reticulum lumen]
F8 S603T [endoplasmic reticulum lumen]
F8 V2144_Y2351delinsHGVLENGKNWEPSYRW [endoplasmic reticulum lumen]
F8 R1329H [endoplasmic reticulum lumen]
F8 N601K [endoplasmic reticulum lumen]
F8 R2016W [endoplasmic reticulum lumen]
F8 L1481P [endoplasmic reticulum lumen]
F8 S603R [endoplasmic reticulum lumen]
F8 M633T [endoplasmic reticulum lumen]
F8 N1941S [endoplasmic reticulum lumen]
F8 A488T [endoplasmic reticulum lumen]
F8 R612C [endoplasmic reticulum lumen]
F8 D337N [endoplasmic reticulum lumen]
F8 A20_M2143delinsMRIQDPGK [endoplasmic reticulum lumen]
F8 D599V [endoplasmic reticulum lumen]
F8 N2137Q [endoplasmic reticulum lumen]
F8 E600K [endoplasmic reticulum lumen]
F8 N601D [endoplasmic reticulum lumen]
F8 N601H [endoplasmic reticulum lumen]
F8 C348S [endoplasmic reticulum lumen]
F8 S603C [endoplasmic reticulum lumen]
F8 A488S [endoplasmic reticulum lumen]
F8 N1941D [endoplasmic reticulum lumen]
F8 G1967D [endoplasmic reticulum lumen]
F8 P2067L [endoplasmic reticulum lumen]
F8 G720D [endoplasmic reticulum lumen]
F8 P2162L [endoplasmic reticulum lumen]
F8 M633I [endoplasmic reticulum lumen]
F8 C348R [endoplasmic reticulum lumen]
F8 R2178C [extracellular region]
F8 I2117S [extracellular region]
F8 P2319S [extracellular region]
F8 P2319L [extracellular region]
F8 P1828L [extracellular region]
F8 R2323H [extracellular region]
F8 S2138Y [extracellular region]
F8 R2169H [extracellular region]
F8 Y1699F [extracellular region]
F8 S2192I [extracellular region]
F8 Q2106E [extracellular region]
F8 R2326Q [extracellular region]
F8 Q2330P [extracellular region]
F8 A2220P [extracellular region]
F8 A2220del [extracellular region]
F8 R1708C [extracellular region]
F8 R1708H [extracellular region]
F8 R391C [extracellular region]
F8 R391H [extracellular region]
F8 S392L [extracellular region]
F8 Y365C [extracellular region]
OSulf-6Y-FVIII precursor [Golgi lumen]
Factor VIII precursor [Golgi lumen]
F8 Y1699F [Golgi lumen]
F8(373-581) [extracellular region]
F8(20-355) [extracellular region]
F8(582-640) [extracellular region]
F8(356-372) [extracellular region]
F8(392-759) N713I [extracellular region]
F8(392-759) R550G [extracellular region]
F8(392-759) R550H [extracellular region]
F8(392-759) R717L [extracellular region]
F8(392-759) R717W [extracellular region]
F8(392-759) R550C [extracellular region]
F8(20-391) S308L [extracellular region]
F8(20-391) A303E [extracellular region]
factor VIIIa A3 C1 C2 polypeptide [extracellular region]
factor VIIIa A2 polypeptide [extracellular region]
factor VIIIa A1 polypeptide [extracellular region]
factor VIIIa B A3 acidic polypeptide [extracellular region]
factor VIII heavy chain [extracellular region]
factor VIIIa A1 polypeptide [plasma membrane]
factor VIIIa A3 C1 C2 polypeptide [plasma membrane]
factor VIIIa A2 polypeptide [plasma membrane]
Factor VIII precursor [endoplasmic reticulum-Golgi intermediate compartment membrane]
Factor VIII precursor [COPII-coated ER to Golgi transport vesicle]
Factor VIII precursor [endoplasmic reticulum lumen]
Inferred To
F8 [extracellular region] (Bos taurus)
F8 [extracellular region] (Gallus gallus)
F8 [extracellular region] (Mus musculus)
F8 [extracellular region] (Rattus norvegicus)
factor VIII light chain [extracellular region] (Xenopus tropicalis)
f8 [extracellular region] (Danio rerio)
Cross References
RefSeq
NP_000123.1
,
NP_063916.1
OpenTargets
ENSG00000185010
ZINC - Substances
FA8_HUMAN
GeneCards
P00451
HPA
ENSG00000185010-F8
Ensembl
ENSP00000353393
,
ENSP00000327895
,
ENSG00000185010
,
ENST00000330287
,
ENST00000360256
ZINC target
P00451
PRO
P00451
Orphanet
16016
ZINC - Predictions - Purchasable
FA8_HUMAN
HMDB Protein
HMDBP01727
PDB
4BDV
,
3CDZ
,
1D7P
,
5K8D
,
1CFG
,
2R7E
,
4XZU
,
1FAC
,
4PT6
,
3HOB
,
1IQD
,
3J2S
,
4KI5
,
3J2Q
,
3HNY
,
3HNB
,
6MF2
© 2021
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
![factor VIII light chain [extracellular region] icon](/icon/R-ICO-014166.svg){kind=icon}
