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HC-335-F9(227-461) [plasma membrane]
Stable Identifier
R-HSA-158225
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
HC-335-FIXa, factor IXa heavy chain
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of hemostasis (Homo sapiens)
Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) (Homo sapiens)
Defective factor VIII causes hemophilia A (Homo sapiens)
Defective cofactor function of FVIIIa variant (Homo sapiens)
FVIIIa variant:FIXa does not convert FX to the active FXa (Homo sapiens)
FVIIIa variant:FIXa [plasma membrane] (Homo sapiens)
factor IXa [plasma membrane] (Homo sapiens)
HC-335-F9(227-461) [plasma membrane] (Homo sapiens)
Hemostasis (Homo sapiens)
Formation of Fibrin Clot (Clotting Cascade) (Homo sapiens)
Intrinsic Pathway of Fibrin Clot Formation (Homo sapiens)
factor IXa associates with cell membrane (Homo sapiens)
factor IXa [plasma membrane] (Homo sapiens)
HC-335-F9(227-461) [plasma membrane] (Homo sapiens)
factor VIIIa + factor IXa -> factor VIIIa:factor IXa (Homo sapiens)
factor IXa [plasma membrane] (Homo sapiens)
HC-335-F9(227-461) [plasma membrane] (Homo sapiens)
factor VIIIa:factor IXa [plasma membrane] (Homo sapiens)
factor IXa [plasma membrane] (Homo sapiens)
HC-335-F9(227-461) [plasma membrane] (Homo sapiens)
factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst) (Homo sapiens)
FVIIIa:FIXa:PROS1 [plasma membrane] (Homo sapiens)
factor VIIIa:factor IXa [plasma membrane] (Homo sapiens)
factor IXa [plasma membrane] (Homo sapiens)
HC-335-F9(227-461) [plasma membrane] (Homo sapiens)
factor VIIIa:factor IXa [plasma membrane] (Homo sapiens)
factor IXa [plasma membrane] (Homo sapiens)
HC-335-F9(227-461) [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P00740 F9
Gene Names
F9
Chain
signal peptide:1-28, propeptide:29-46, chain:47-461, chain:47-191, propeptide:192-226, chain:227-461
Reference Genes
BioGPS Gene:2158 F9
COSMIC (genes):F9 F9
CTD Gene:2158 F9
dbSNP Gene:2158 F9
ENSEMBL:ENSG00000101981 F9
HGNC:3551 F9
KEGG:hsa:2158 F9
Monarch:2158 F9
NCBI Gene:2158 F9
OMIM:300746 F9
UCSC:P00740 F9
Reference Transcript
RefSeq:NM_000133.3 F9
RefSeq:NM_001313913.1 F9
Other Identifiers
11735185_a_at
11735186_a_at
11735187_at
11745643_a_at
17107373
207218_PM_at
207218_at
2158
35556_at
3993078
3993079
3993081
3993082
3993084
3993085
3993086
3993090
3993091
3993092
3993093
3993094
3993095
8170215
A_14_P113911
A_14_P200623
A_23_P62406
A_33_P3390411
GE80895
GO:0003824
GO:0004175
GO:0004252
GO:0005509
GO:0005515
GO:0005576
GO:0005615
GO:0005788
GO:0005796
GO:0005886
GO:0006508
GO:0007596
GO:0008233
GO:0008236
GO:0016787
GO:0030312
GO:0031012
GO:0031638
GO:0043226
GO:0046872
GO:0051604
GO:0062023
GO:0070062
GO:0140096
HMNXSV003019692
ILMN_1810651
K02402_at
PH_hs_0000181
TC0X000676.hg
g10518507_3p_at
Participates
as a component of
factor IXa [plasma membrane] (Homo sapiens)
Other forms of this molecule
F9(227-461) R384L [plasma membrane]
3OHD110-F9(29-461) N43L [endoplasmic reticulum lumen]
3OHD110-F9(29-461) N46S [endoplasmic reticulum lumen]
3OHD110-F9(29-461) N43Q [endoplasmic reticulum lumen]
3OHD110-F9(29-461) N43W [endoplasmic reticulum lumen]
12xCbxE-3D-F9(47-461) R191H [extracellular region]
F9(29-461) R43Q [extracellular region]
F9(29-461) R43W [extracellular region]
12xCbxE-3D-F9(47-461) R191C [extracellular region]
F9(29-461) R46S [extracellular region]
12xCbxE-3D-F9(47-461) R226W [extracellular region]
F9(29-461) R43L [extracellular region]
12xCbxE-3D-F9(47-461) R226Q [extracellular region]
12xCbxE-3D-F9(47-461) R226G [extracellular region]
F9(227-461) G409V [plasma membrane]
F9(227-461) I443T [plasma membrane]
F9(227-461) S411G [plasma membrane]
F9(227-461) G363E [plasma membrane]
F9(227-461) G363R [plasma membrane]
F9(227-461) D410H [plasma membrane]
F9(227-461) V359D [plasma membrane]
F9(227-461) G357E [plasma membrane]
F9(227-461) A436V [plasma membrane]
F9(227-461) S411I [plasma membrane]
F9(227-461) V419E [plasma membrane]
F9(227-461) G357R [plasma membrane]
F9(227-461) S411T [plasma membrane]
F9(29-461) R294* [endoplasmic reticulum lumen]
F9(29-461) R162R [endoplasmic reticulum lumen]
F9(29-461) Y450C [endoplasmic reticulum lumen]
F9(29-461) C28_V30delinsF [endoplasmic reticulum lumen]
F9(29-461) C155Y [endoplasmic reticulum lumen]
F9(29-461) C117Y [endoplasmic reticulum lumen]
F9(29-461) L163F [endoplasmic reticulum lumen]
F9(29-461) W453R [endoplasmic reticulum lumen]
F9(29-461) Q167H [endoplasmic reticulum lumen]
F9(29-461) R384* [endoplasmic reticulum lumen]
F9(29-461) A164V [endoplasmic reticulum lumen]
F9(29-461) V153V [endoplasmic reticulum lumen]
F9(29-461) R298* [endoplasmic reticulum lumen]
F9(29-461) R294Q [endoplasmic reticulum lumen]
F9(29-461) Y330* [endoplasmic reticulum lumen]
F9(29-461) T458K [endoplasmic reticulum lumen]
F9(29-461) R162* [endoplasmic reticulum lumen]
F9(29-461) C28* [endoplasmic reticulum lumen]
12xCbxE-3D-HC-C178-F9(47-191) [plasma membrane]
12xCbxE-3D-F9(47-461) [extracellular region]
12xCbxE-3D-HC-C178-F9(47-191) [extracellular region]
HC-C335-F9(227-461) [extracellular region]
factor IX activation peptide [extracellular region]
F9(29-461) [endoplasmic reticulum lumen]
3OHD110-F9(29-461) [endoplasmic reticulum lumen]
12xCbxE-3D-F9(29-461) [endoplasmic reticulum lumen]
12xCbxE-3D-F9(29-461) [Golgi lumen]
factor IX propeptide [Golgi lumen]
12xCbxE-3D-F9(47-461) [Golgi lumen]
Inferred To
f9 [plasma membrane]
(Xenopus tropicalis)
f9b [plasma membrane]
(Danio rerio)
F9 [plasma membrane]
(Bos taurus)
F9 [plasma membrane]
(Canis familiaris)
F9 [plasma membrane]
(Sus scrofa)
HC-335-F9(227-461) [plasma membrane]
(Gallus gallus)
HC-335-F9(227-461) [plasma membrane]
(Mus musculus)
HC-335-F9(227-461) [plasma membrane]
(Rattus norvegicus)
Modified Residues
Name
Inter-chain Crosslink via L-cystine (cross-link) at 335 and 178
Coordinate
335
PsiMod Name
L-cystine (cross-link)
PsiMod Definition
A protein modification that effectively cross-links two L-cysteine residues to form L-cystine.
Cross References
Guide to Pharmacology - Targets
2364
OpenTargets
ENSG00000101981
ENSEMBL
ENSP00000377650
,
ENSP00000218099
,
ENST00000394090
,
ENST00000218099
,
ENSG00000101981
ZINC - Substances
FA9_HUMAN
ZINC target
P00740
PRO
P00740
GlyGen
P00740
PDB
5VYG
,
4WMK
,
6X5L
,
6X5J
,
5EGM
,
6X5P
,
1MGX
,
1EDM
,
4WMI
,
2WPH
,
2WPI
,
2WPJ
,
4WN2
,
1CFH
,
1CFI
,
4WMB
,
1NL0
,
4WMA
,
3KCG
,
1IXA
,
2WPK
,
4YZU
,
5JB8
,
2WPL
,
6RFK
,
4WM0
,
7AHV
,
2WPM
,
5JB9
,
5F84
,
5JBB
,
5JBA
,
4Z0K
,
5TNO
,
6MV4
,
5JBC
,
5F85
,
8EPC
,
5F86
,
3LC3
,
4ZAE
,
4WNH
,
5TNT
,
8EPK
,
8EPH
,
3LC5
,
8OL9
,
1RFN
ZINC - Investigational
FA9_HUMAN
GeneCards
F9
HPA
ENSG00000101981-F9
Pharos - Targets
P00740
Orphanet
F9
ZINC - Predictions - Purchasable
FA9_HUMAN
HMDB Protein
HMDBP01730
Interactors (15)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q3U4G3 XXLT1
0.618
3
UniProt:P00451-PRO_0000002968 F8
0.544
2
UniProt:O95071 UBR5
0.527
3
UniProt:P35453 HXD13
0.527
2
UniProt:O75197 LRP5
5
LRP5 [plasma membrane]
(R-HSA-201671)
p-5S,5T-LRP5 [plasma membrane]
(R-HSA-1458893)
p-3S,2T-LRP5 [plasma membrane]
(R-HSA-1458905)
LRP5 [early endosome membrane]
(R-HSA-5368479)
LRP5 D666_L809del [plasma membrane]
(R-HSA-5339694)
0.527
2
UniProt:Q8IYL2 TRMT44
1
TRMT44 [cytosol]
(R-HSA-6788685)
0.527
2
UniProt:Q9BYW2 SETD2
1
SETD2 [nucleoplasm]
(R-HSA-1183220)
0.527
2
UniProt:Q9Y305 ACOT9
1
ACOT9 [mitochondrial matrix]
(R-HSA-5690069)
0.527
2
UniProt:Q9NWK9 BCD1
0.527
2
UniProt:Q5NDL2 EOGT
0.527
2
UniProt:Q96PK6 RBM14
1
RBM14 [nucleoplasm]
(R-HSA-8938345)
0.527
2
UniProt:Q9BVC3 DSCC1
1
DSCC1 [nucleoplasm]
(R-HSA-9668907)
0.527
2
UniProt:Q8N4L2 PP4P2
0.527
3
UniProt:Q8NBL1 POGLUT1
1
POGLUT1 [endoplasmic reticulum lumen]
(R-HSA-1464796)
0.527
2
UniProt:P25490 YY1
1
YY1 [nucleoplasm]
(R-HSA-4086091)
0.527
2
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